cilonic gel

4.5 (15 reviews)

Diclofenac (1.16% w/w) Linseed Oil (3% w/w)

🏭 Trigat Lifesciences Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 21, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 21, 2026

What is cilonic gel used for?

Axinac Nano Gel (Diclofenac + Linseed Oil) is used to treat DERMA. It contains Diclofenac (1.16% w/w) + Linseed Oil (3% w/w), which Diclofenac inhibits cyclooxygenase (COX-1 and COX-2), reducing prostaglandin syn. Always consult your doctor before use. Take as prescribed.

Generic Name: Diclofenac + Linseed Oil
Manufacturer: Trigat Lifesciences Pvt Ltd
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 cilonic gel Uses & Benefits

Local relief of pain and inflammation in musculoskeletal conditions such as osteoarthritis, rheumatoid arthritis, sprains, strains, and sports injuries.

Off-label uses: Tendinopathy, bursitis, and other soft tissue inflammatory conditions.

📋 Drug Information

Generic Name(s)	Diclofenac + Linseed Oil
Brand Name	Axinac Nano Gel
Manufacturer	Trigat Lifesciences Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	DERMA
Action Class	Nonsteroidal Anti-inflammatory Drug (NSAID) + Emollient
Route of Administration	Topical
Storage	Store at room temperature (20-25°C); keep tube tightly closed; avoid freezing.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionTopical absorption; systemic absorption is minimal (approximately 6% of applied dose) but can be enhanced by damaged skin or prolonged use.

DistributionDistributes locally to subcutaneous tissues; systemic distribution is low due to limited absorption.

Protein BindingDiclofenac: >99% bound to plasma proteins, primarily albumin.

MetabolismDiclofenac: Hepatic metabolism via CYP2C9 and glucuronidation; linseed oil is not significantly metabolized.

Half-LifeDiclofenac: Approximately 1-2 hours (systemic); topical application results in prolonged local prese

ExcretionDiclofenac: Renal excretion (65% as metabolites, 35% as unchanged drug) and biliary excretion.

BioavailabilityTopical: Low systemic bioavailability (~6% of applied dose).

Onset of ActionWithin 1-2 hours after application.

Peak Plasma TimeNot applicable for topical; local effect peaks within 2-4 hours.

Duration of ActionUp to 8-12 hours per application.

How It Works

Diclofenac inhibits cyclooxygenase (COX-1 and COX-2), reducing prostaglandin synthesis; linseed oil provides emollient and anti-inflammatory effects via omega-3 fatty acids.

Mechanism Steps

1Diclofenac binds to COX-1 and COX-2 enzymes, inhibiting conversion of arachidonic acid to prostaglandins.

2Reduced prostaglandin synthesis decreases inflammation, pain, and fever locally.

3Linseed oil provides omega-3 fatty acids that compete with arachidonic acid, reducing pro-inflammatory eicosanoids.

💡 How to Take cilonic gel

Follow your doctor's prescription exactly.

⚠️ Side Effects of cilonic gel

✅ Common Side Effects

Application site reactions (rash, itching, burning, redness)
Dry skin
Contact dermatitis

🚨 Serious Side Effects

Gastrointestinal bleeding (rare with topical use)
Renal impairment (rare)
Severe allergic reactions (anaphylaxis)

⚠️ Rare Side Effects

Photosensitivity
Stevens-Johnson syndrome
Hepatotoxicity

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Warfarin	Major	Increased bleeding risk
Other NSAIDs	Major	Additive gastrointestinal toxicity
Anticoagulants	Major	Enhanced anticoagulant effect
Lithium	Major	Increased lithium levels
Methotrexate	Major	Increased methotrexate toxicity
ACE inhibitors	Moderate	Reduced antihypertensive effect
Diuretics	Moderate	Reduced diuretic effect
Aspirin	Moderate	Increased bleeding risk
Corticosteroids	Moderate	Increased gastrointestinal ulcer risk
Antacids	Minor	May reduce absorption if applied concurrently
Cholestyramine	Minor	May reduce absorption if applied concurrently

🚨 Major Interactions

Warfarin
Other NSAIDs
Anticoagulants
Lithium
Methotrexate

⚡ Moderate Interactions

ACE inhibitors
Diuretics
Aspirin
Corticosteroids

ℹ️ Minor Interactions

Antacids
Cholestyramine

🍽️ Food Interactions

No significant food interactions for topical use.

🍷 Alcohol Interaction

No direct interaction, but alcohol may increase risk of gastrointestinal bleeding if systemic absorption is high.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to diclofenac, aspirin, or other NSAIDs; active peptic ulcer; severe renal or hepatic impairment; third trimester of pregnancy; application on broken skin or open wounds.

📊 Monitoring Parameters

Monitor for skin irritation, allergic reactions, and signs of systemic effects (e.g., gastrointestinal bleeding, renal impairment) with prolonged use.

🤱 Lactation Safety

Limited data; use with caution. Diclofenac is excreted in breast milk in low amounts.

💊 Overdose Management

Topical overdose unlikely; if ingested accidentally, treat symptomatically; activated charcoal may be considered.

⏰ Missed Dose

Apply as soon as remembered; if near next dose, skip missed dose and resume regular schedule; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 21, 2026

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⭐ User Reviews

Regular Customer Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Happy Patient Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.