Chloramphenicol (5% w/w) + Clotrimazole (1% w/w) + Beclometasone (0.025% w/w) (Medical Monograph)

Overview

A fixed-dose combination topical preparation containing a broad-spectrum antibiotic (Chloramphenicol), an antifungal agent (Clotrimazole), and a potent corticosteroid (Beclometasone). It is primarily indicated for the treatment of mixed bacterial and fungal skin infections complicated by inflammation and pruritus. This combination provides a synergistic effect against common dermatological pathogens while controlling the inflammatory response.

The combination exerts a triple action: Chloramphenicol inhibits bacterial protein synthesis, Clotrimazole disrupts fungal cell membrane integrity, and Beclometasone suppresses inflammation and immune response.