Azuvas-F 20 Tablet: Complete Guide to Uses, Side Effects, and Safety
When to Call Your Doctor IMMEDIATELY
- Unexplained muscle pain, tenderness, or weakness, especially with fever or malaise
- Dark urine or decreased urine output
- Yellowing of skin or eyes (jaundice)
- Severe abdominal pain radiating to the back, with nausea and vomiting
- Swelling of face, lips, tongue, or throat, or difficulty breathing
- Unusual bleeding or bruising
- Persistent nausea, vomiting, or loss of appetite
- Right upper quadrant abdominal pain
If experiencing severe symptoms, call emergency services immediately.
What is cgros f 160mg/20mg tablet used for?
This medicine is a prescription combination of fenofibrate 160 mg and rosuvastatin 20 mg used to treat mixed dyslipidemia by lowering triglycerides and LDL cholesterol while raising HDL cholesterol. It is taken once daily with meals, and regular monitoring of liver and kidney function is required.
- Generic Name: Fenofibrate + Rosuvastatin
- Manufacturer: Cmg Biotech Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cgros f 160mg/20mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा फेनोफाइब्रेट 160 मिलीग्राम और रोसुवास्टेटिन 20 मिलीग्राम का संयोजन है, जिसका उपयोग मिश्रित डिस्लिपिडेमिया के इलाज के लिए किया जाता है। यह ट्राइग्लिसराइड और एलडीएल कोलेस्ट्रॉल को कम करने और एचडीएल कोलेस्ट्रॉल को बढ़ाने में मदद करती है। यह दवा उन वयस्कों के लिए है जिन्हें आहार और व्यायाम के बावजूद कोलेस्ट्रॉल और ट्राइग्लिसराइड के स्तर को नियंत्रित करने के लिए दोनों दवाओं की आवश्यकता होती है। इसे डॉक्टर के परामर्श के बिना नहीं लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, मतली, पेट दर्द, कब्ज और मांसपेशियों में दर्द शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें रैब्डोमायोलिसिस, लीवर की समस्या और पैन्क्रियाटाइटिस शामिल हो सकते हैं। यदि आपको अस्पष्टीकृत मांसपेशियों में दर्द, कमजोरी, गहरे रंग का पेशाब, या त्वचा या आंखों का पीलापन दिखाई दे, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे भोजन के साथ लें ताकि पेट की परेशानी कम हो और अवशोषण बेहतर हो। अंगूर का रस न पिएं क्योंकि यह दवा के स्तर को बढ़ा सकता है। गर्भावस्था और स्तनपान के दौरान इस दवा का सेवन न करें। शराब का सेवन न करें या सीमित करें। नियमित रूप से लीवर और किडनी की जांच कराएं। यदि मांसपेशियों में दर्द या कमजोरी हो तो तुरंत डॉक्टर को बताएं।
💊 cgros f 160mg/20mg tablet Uses & Benefits
[{"condition":"Mixed dyslipidemia","description":"This medicine is used to reduce elevated LDL cholesterol, total cholesterol, triglycerides, and apolipoprotein B, and to increase HDL cholesterol in adults with mixed dyslipidemia when both statin and fibrate therapy are needed.","evidence":"Well-established"},{"condition":"Primary hypercholesterolemia","description":"Rosuvastatin component effectively lowers LDL cholesterol in patients with primary hypercholesterolemia, while fenofibrate addresses associated hypertriglyceridemia.","evidence":"Well-established"},{"condition":"Hypertriglyceridemia","description":"Fenofibrate component significantly reduces triglyceride levels in patients with severe hypertriglyceridemia, reducing the risk of pancreatitis.","evidence":"Well-established"},{"condition":"Dysbetalipoproteinemia","description":"This combination is effective in treating dysbetalipoproteinemia (type III hyperlipoproteinemia) by improving remnant lipoprotein clearance.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Non-alcoholic fatty liver disease","description":"Some studies suggest fenofibrate and statins may improve liver enzymes and lipid profiles in NAFLD, but this is not an approved indication.","evidence":"Limited"},{"condition":"Diabetic dyslipidemia","description":"The combination may be used off-label to manage atherogenic dyslipidemia in patients with type 2 diabetes, though statins are first-line.","evidence":"Moderate"}]
Primary treatment for: Mixed dyslipidemia
Also treats: Hypertriglyceridemia, Primary hypercholesterolemia, Dysbetalipoproteinemia, Diabetic dyslipidemia
📋 Drug Information
| Generic Name(s) | Fenofibrate + Rosuvastatin |
| Brand Name | Arvast F 10 Tablet |
| Manufacturer | Cmg Biotech Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Lipid-lowering agent (Fibrate + Statin) |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and light. Keep the tablets in the original container, tightly closed. Do not refrigerate or freeze. |
| Shelf Life | 24 months from the date of manufacture, or as indicated on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two lipid-lowering agents with complementary mechanisms. Fenofibrate activates peroxisome proliferator-activated receptor alpha (PPAR-alpha), which regulates the expression of genes involved in lipid metabolism. This activation increases lipoprotein lipase activity, enhances fatty acid oxidation, and reduces hepatic triglyceride production, leading to lower triglyceride levels and increased HDL cholesterol. Rosuvastatin selectively inhibits HMG-CoA reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, a rate-limiting step in cholesterol biosynthesis. This inhibition upregulates LDL receptors on hepatocytes, increasing clearance of LDL cholesterol from the blood and reducing total cholesterol and triglycerides while modestly raising HDL cholesterol.
Mechanism Steps
💡 How to Take cgros f 160mg/20mg tablet
Strength: Each tablet contains fenofibrate 160 mg and rosuvastatin 20 mg.
Dosage Information
| Adult Dosage | The recommended dose of this medicine is one tablet taken orally once daily. The dosage is individualized by a qualified clinician based on the patient's lipid profile, cardiovascular risk, renal and hepatic function, and response to therapy. It may be taken with or without food, but taking it with meals is preferred to enhance fenofibrate absorption and reduce gastrointestinal upset. Dose adjustments may be necessary in patients with renal impairment or those taking interacting medications. Do not exceed the prescribed dose. Regular monitoring of lipid levels, liver enzymes, and kidney function is required. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (65 years and older) may be more sensitive to the effects of this medicine. Dose selection should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and concomitant disease or other drug therapy. Regular monitoring of renal function is particularly important in elderly patients. |
| Renal Impairment | In patients with mild to moderate renal impairment (eGFR 30-89 mL/min/1.73 m²), no dose adjustment is usually required, but caution is advised. In patients with severe renal impairment (eGFR <30 mL/min/1.73 m²), this medicine is contraindicated. Rosuvastatin doses should be reduced in patients with severe renal impairment. Fenofibrate should be used with caution and dose reduction may be necessary. Consult a nephrologist or clinical pharmacist for individualized dosing. |
| Hepatic Impairment | This medicine is contraindicated in patients with active liver disease or unexplained persistent elevations of serum transaminases. In patients with mild to moderate hepatic impairment, no specific dose adjustment is established, but use with caution and monitor liver function closely. In severe hepatic impairment, the medicine should not be used. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet containing fenofibrate 160 mg and rosuvastatin 20 mg. Do not exceed this dose unless specifically instructed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cgros f 160mg/20mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Cyclosporine | Major | |
| Gemfibrozil | Major | |
| Protease inhibitors | Major | |
| Niacin | Moderate | |
| Colchicine | Moderate | |
| Azole antifungals | Moderate | |
| Macrolide antibiotics | Moderate | |
| Antacids | Minor | |
| Digoxin | Minor |
🚨 Major Interactions
- Warfarin
- Cyclosporine
- Gemfibrozil
- Protease inhibitors
⚡ Moderate Interactions
- Fibrates (other than gemfibrozil)
- Niacin
- Colchicine
- Azole antifungals
- Macrolide antibiotics
🍷 Alcohol Interaction
Alcohol should be avoided or limited while taking this medicine. Both fenofibrate and rosuvastatin can affect liver function, and alcohol increases the risk of hepatotoxicity. Additionally, alcohol can raise triglyceride levels, counteracting the therapeutic effect of fenofibrate. Patients with a history of liver disease or heavy alcohol use should discuss with their doctor before taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active liver disease or unexplained persistent elevations of serum transaminases","Severe renal impairment (eGFR
⚠️ Warnings & Precautions
["Muscle effects: Rhabdomyolysis with acute renal failure has been reported. Patients should be advised to report unexplained muscle pain, tenderness, or weakness, especially if accompanied by malaise or fever.","Liver effects: Increases in serum transaminases have been reported. Liver function tests should be performed before and during therapy.","Renal effects: Fenofibrate may increase creatinine and urea nitrogen. Monitor renal function in patients with renal impairment.","Pancreatitis: Cases have been reported in patients taking fenofibrate, particularly those with severely elevated triglycerides.","Hypersensitivity reactions: Anaphylaxis, angioedema, and urticaria have been reported.","Endocrine effects: Fenofibrate may cause reversible increases in serum creatinine and may affect thyroid function tests.","Hematologic effects: Mild decreases in hemoglobin, hematocrit, and white blood cell count have been observed.","Neurologic effects: Dizziness and fatigue may occur; patients should avoid driving or operating machinery until they know how the medicine affects them.","Drug interactions: Concomitant use with warfarin, cyclosporine, gemfibrozil, and other fibrates requires caution.","Pediatric use: Safety and effectiveness in patients under 18 years have not been established."]
🤱 Lactation Safety
This medicine is contraindicated during breastfeeding. It is not known whether fenofibrate or rosuvastatin are excreted in human milk, but due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
💊 Overdose Management
There is no specific antidote for overdose with this medicine. In case of suspected overdose, symptomatic and supportive measures should be instituted. Monitor liver and kidney function, creatine kinase levels, and vital signs. Hemodialysis is not expected to significantly enhance clearance of fenofibrate or rosuvastatin. Contact a poison control center or emergency department immediately if overdose is suspected.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you are unsure what to do, contact your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without medical advice. Swallow the tablet whole with a glass of water, with or without food, but preferably with meals to reduce stomach upset and improve absorption. Avoid drinking grapefruit juice while on this medicine, as it can increase rosuvastatin levels and the risk of side effects. Inform your doctor if you have a history of liver disease, kidney disease, thyroid disorders, or muscle disorders. Regular blood tests to check liver function, kidney function, and lipid levels are important. Do not take this medicine if you are pregnant, planning to become pregnant, or breastfeeding. Use effective contraception while taking this medicine. Avoid excessive alcohol consumption, as it can increase the risk of liver problems. If you experience unexplained muscle pain, weakness, or dark urine, contact your doctor immediately. Keep all appointments for monitoring and follow-up.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to the side effects of this medicine, particularly muscle and kidney toxicity. Dose selection should be cautious, and renal function should be monitored regularly. Falls and fractures risk may be increased with statin use in the elderly. Discuss the risks and benefits with your doctor.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated during pregnancy and in women planning to become pregnant. If you are planning pregnancy, consult your doctor to switch to a safer alternative. Use effective contraception while taking this medicine. If you become pregnant while on this medicine, discontinue immediately and contact your doctor.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may need to be temporarily discontinued, especially if you are at risk of bleeding or kidney problems. Follow your doctor's instructions regarding when to resume the medicine after surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. There is no specific contraindication, but if you are taking anticoagulants like warfarin, your dentist should be aware of the increased bleeding risk. Maintain good oral hygiene and regular dental check-ups.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is encouraged, but if you experience muscle pain, tenderness, or weakness, stop exercising and consult your doctor. Intense or unaccustomed exercise may increase the risk of muscle injury, especially when combined with statin therapy. Stay well hydrated during exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue in some patients. Avoid driving or operating heavy machinery until you know how it affects you. Most patients can continue their normal daily activities without significant disruption. Inform your employer if your job involves operating machinery or driving.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as severe muscle pain, dark urine, or yellowing of the skin or eyes, contact your doctor immediately. Your doctor may decide to discontinue the medicine or adjust the dose based on your clinical response and laboratory results.
📅 Long-Term Use Effects
Long-term use of this medicine requires regular monitoring of liver enzymes, kidney function, and lipid profile. Most patients tolerate it well, but there is a rare risk of muscle and liver toxicity. The cardiovascular benefits of sustained lipid control generally outweigh the risks. Periodic assessment of the risk-benefit ratio is recommended, especially in elderly patients and those with multiple comorbidities.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet, exercise, and weight management can improve lipid profiles and reduce the need for medication.
Evidence: Well-establishedMay help lower triglycerides, but less effective than fibrates.
Evidence: ModerateCan improve lipid profile but has limited use due to side effects.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. Patients should continue routine vaccinations as recommended by their healthcare provider. However, if you are acutely ill with fever, consult your doctor before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate or freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. Store at room temperature and protect from moisture. If crossing time zones, continue taking your dose at the same time each day as much as possible; consult your doctor for specific advice. Check local customs regulations for carrying prescription medicines. Carry enough supply for your entire trip and a few extra days in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering lipid levels within 1 to 2 weeks, with maximal effects seen after 4 to 6 weeks of continuous use.
A: Yes, it is best taken with meals to enhance absorption and reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: Avoid grapefruit juice as it can increase rosuvastatin levels. Limit alcohol intake as it can increase the risk of liver problems.
A: No, this medicine is usually a long-term treatment. Stopping without medical advice can lead to rebound lipid elevations and increased cardiovascular risk.
🤔 Common Patient Concerns
🔄 Substitutes for cgros f 160mg/20mg tablet
View AllAlternative brands with exact same active ingredient:
-
azuvas-f 20 tabletAzkka Pharmaceuticals Pvt Ltd ₹119.90 42.6% CHEAPER
-
rolipitin f forte 160mg/20mg tabletEast West Pharma ₹173.44 17% CHEAPER
-
rozat-f 160mg/20mg tabletDr Reddy's Laboratories Ltd ₹176.25 15.7% CHEAPER
-
rosuday-f 20 tabletPrevego Healthcare & Research Private Limited ₹235.00 12.4% COSTLIER
-
rosuline-f 20 tabletJohnlee Pharmaceuticals Pvt Ltd ₹265.31 26.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken without any monitoring.
Fact: Regular blood tests for liver function, kidney function, and lipid levels are essential while taking this medicine. - Myth: This medicine is safe to take during pregnancy.
Fact: This medicine is contraindicated during pregnancy and breastfeeding due to potential harm to the fetus or infant. - Myth: You can stop this medicine once your cholesterol levels improve.
Fact: This medicine is usually a long-term treatment. Stopping without medical advice can lead to rebound lipid elevations and increased cardiovascular risk. - Myth: This medicine can replace diet and exercise.
Fact: This medicine is an adjunct to diet and exercise, which remain the foundation of managing dyslipidemia.
🔄 Alternative Options
Generic Alternatives
- Fenofibrate + Rosuvastatin
Brand Alternatives
- Azuvas-F 20 Tablet