Amicef O 100mg/100mg Tablet: Complete Information
When to Call Your Doctor IMMEDIATELY
- Severe allergic reaction (swelling of face, lips, throat, difficulty breathing)
- Tendon pain, swelling, or rupture
- Severe or bloody diarrhea
- Seizures or severe dizziness
- Numbness or tingling in hands or feet
- Yellowing of skin or eyes
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is cfx o 100mg/100mg tablet used for?
This medicine is a combination antibiotic containing Cefixime and Ofloxacin, used to treat various bacterial infections such as typhoid, urinary tract infections, and respiratory infections. It works by killing bacteria through two different mechanisms. It should be taken exactly as prescribed, and the full course must be completed.
- Generic Name: Cefixime + Ofloxacin
- Manufacturer: Skymax Laboratories Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cfx o 100mg/100mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा सेफिक्सिम और ओफ्लोक्सासिन का संयोजन है, जिसका उपयोग विभिन्न जीवाणु संक्रमणों जैसे टाइफाइड, मूत्र मार्ग संक्रमण, श्वसन तंत्र संक्रमण और त्वचा संक्रमण के इलाज के लिए किया जाता है। यह दवा बैक्टीरिया को मारकर काम करती है। इसे डॉक्टर के निर्देशानुसार ही लें और पूरा कोर्स पूरा करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त, पेट दर्द, सिरदर्द, चक्कर आना और दाने शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी, टेंडन टूटना, दौरे और गंभीर दस्त शामिल हो सकते हैं। कोई भी असामान्य लक्षण होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुराक न छोड़ें और कोर्स पूरा करें। दवा को भोजन के साथ या बिना भोजन के ले सकते हैं, लेकिन पेट की परेशानी हो तो भोजन के साथ लें। एंटासिड, डेयरी उत्पाद या आयरन सप्लीमेंट के साथ 2 घंटे का अंतराल रखें। शराब न पिएं। धूप से बचें। टेंडन में दर्द या सूजन होने पर तुरंत डॉक्टर से मिलें।
💊 cfx o 100mg/100mg tablet Uses & Benefits
[{"condition":"Typhoid fever","description":"Used to treat enteric fever caused by Salmonella typhi, especially when combination therapy is considered.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Effective against complicated and uncomplicated UTIs caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Respiratory tract infections","description":"Used for community-acquired pneumonia, acute exacerbations of chronic bronchitis, and sinusitis.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats infections like cellulitis, abscesses, and wound infections caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Gonorrhea","description":"May be used as an alternative treatment for uncomplicated gonorrhea, though resistance patterns vary.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Prostatitis","description":"Sometimes used off-label for chronic bacterial prostatitis due to fluoroquinolone activity.","evidence":"Limited"},{"condition":"Traveler's diarrhea","description":"Occasionally prescribed off-label for severe traveler's diarrhea, but not first-line.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Typhoid fever, Urinary tract infections, Respiratory tract infections, Skin infections
📋 Drug Information
| Generic Name(s) | Cefixime + Ofloxacin |
| Brand Name | Abixim O Tablet |
| Manufacturer | Skymax Laboratories Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Antibiotic (Cephalosporin + Fluoroquinolone) |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antibiotics with distinct mechanisms. Cefixime, a cephalosporin, binds to penicillin-binding proteins (PBPs) and inhibits bacterial cell wall synthesis, leading to cell lysis and death. Ofloxacin, a fluoroquinolone, inhibits DNA gyrase and topoisomerase IV, enzymes required for DNA replication, transcription, repair, and recombination, thereby causing bacterial cell death. The combination provides a broader spectrum and may be synergistic against certain pathogens.
Mechanism Steps
💡 How to Take cfx o 100mg/100mg tablet
Strength: Each tablet contains Cefixime 100 mg and Ofloxacin 100 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this combination is one tablet (Cefixime 100 mg + Ofloxacin 100 mg) taken orally twice daily, or as prescribed by your doctor. The duration of treatment depends on the type and severity of infection, typically 5 to 14 days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may require dose adjustment based on renal function. Use with caution due to increased risk of tendon rupture, CNS effects, and renal impairment. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Dose adjustment is required in patients with renal impairment. For creatinine clearance (CrCl) 20-40 mL/min, reduce dose or increase dosing interval. For CrCl <20 mL/min, further reduce dose. Consult a clinician for specific dosing. |
| Hepatic Impairment | No specific dose adjustment is established for hepatic impairment. Use with caution and monitor liver function. |
| Maximum Daily Dose | The maximum recommended daily dose is 200 mg of cefixime and 400 mg of ofloxacin, but this may vary based on indication and renal function. Always follow your doctor's prescription. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cfx o 100mg/100mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Antacids | Major | |
| Theophylline | Major | |
| NSAIDs | Major | |
| Corticosteroids | Moderate | |
| Oral hypoglycemics | Moderate | |
| Probenecid | Moderate | |
| Caffeine | Minor | |
| Iron supplements | Minor | |
| Sucralfate | Moderate |
🚨 Major Interactions
- Warfarin
- Antacids containing aluminum or magnesium
- Theophylline
- NSAIDs
⚡ Moderate Interactions
- Corticosteroids
- Oral hypoglycemics
- Probenecid
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol can increase the risk of central nervous system side effects such as dizziness, drowsiness, and seizures. It may also worsen gastrointestinal irritation and reduce the effectiveness of the antibiotic.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to cephalosporins or fluoroquinolones","History of tendon disorders with fluoroquinolones","Myasthenia gravis","Pregnancy (especially first trimester)","Breastfeeding","Children under 18 years (due to ofloxacin)","Severe renal impairment (dose adjustment required)"]
⚠️ Warnings & Precautions
["Serious allergic reactions can occur. Discontinue if rash or allergic symptoms develop.","Tendonitis and tendon rupture can occur, especially in elderly and those on corticosteroids.","May cause peripheral neuropathy. Discontinue if symptoms occur.","Can cause CNS effects including seizures, dizziness, and confusion.","May worsen myasthenia gravis.","Clostridium difficile-associated diarrhea may occur. Seek medical attention if severe diarrhea develops.","Avoid excessive sun exposure due to photosensitivity.","May affect blood glucose levels in diabetics.","Do not use in children under 18 years.","Complete the full course as prescribed to prevent resistance."]
🤱 Lactation Safety
Cefixime is excreted in breast milk in low amounts and is generally considered compatible with breastfeeding. Ofloxacin is also excreted in breast milk and may cause serious adverse reactions in nursing infants. Therefore, this combination is not recommended during breastfeeding. Consult your doctor for alternative options.
💊 Overdose Management
Overdose may cause nausea, vomiting, dizziness, and seizures. There is no specific antidote. Treatment is supportive and symptomatic. Maintain adequate hydration. In case of overdose, seek immediate medical attention. Hemodialysis may be considered for ofloxacin removal but is not effective for cefixime.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop the course early, even if you feel better, as this can lead to antibiotic resistance. Take the tablet with a full glass of water, with or without food, but taking it with food may reduce stomach upset. Avoid taking antacids, multivitamins, or dairy products within 2 hours before or after this medicine, as they can interfere with absorption. Do not consume alcohol while taking this medicine, as it may increase the risk of central nervous system side effects. Avoid excessive sunlight and use sunscreen, as this medicine can make your skin more sensitive to sunlight. If you experience pain, swelling, or rupture of a tendon, stop taking this medicine and seek medical attention immediately. Inform your doctor if you have kidney or liver problems, epilepsy, or a history of tendon disorders. Do not share this medicine with others, even if they have similar symptoms.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of tendon rupture, CNS effects, and renal impairment. Dose adjustment may be needed based on kidney function. Use with caution and monitor closely.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended if you are planning pregnancy or are pregnant. Consult your doctor for safe alternatives before trying to conceive.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, inform your surgeon that you are taking this medicine. It may interact with anesthetics and other medications used during surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may interact with other medications and increase the risk of bleeding.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities that put stress on tendons while taking this medicine, as it can increase the risk of tendon rupture. If you experience joint pain or swelling, stop exercising and consult your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, drowsiness, or confusion. Avoid driving or operating heavy machinery until you know how it affects you. It is advisable to take rest if you feel unwell. Inform your employer if you need to take sick leave.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor, even if you feel better. Stopping early can lead to incomplete treatment and antibiotic resistance. If you experience serious side effects, contact your doctor immediately; they may advise you to stop.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to antibiotic resistance, fungal overgrowth, and rare but serious effects like tendon damage, peripheral neuropathy, and bone marrow suppression. It should only be used for the prescribed duration. Regular monitoring of kidney and liver function may be required if used for prolonged periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help prevent antibiotic-associated diarrhea.
Evidence: ModerateHelps flush out bacteria and prevent dehydration.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Antibiotics may reduce the effectiveness of live bacterial vaccines like typhoid vaccine. Consult your doctor about vaccination timing if you are scheduled to receive any vaccines.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If crossing time zones, adjust dosing times gradually to maintain even intervals. Check customs regulations for carrying prescription medicines. Always carry enough supply for your trip and a few extra days in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 2-3 days, but it is important to complete the full course as prescribed.
A: Yes, you can take it with or without food. Taking it with food may reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: This medicine is not recommended during pregnancy, especially due to the ofloxacin component. Consult your doctor for alternative antibiotics.
A: No, alcohol should be avoided as it can increase the risk of side effects such as dizziness and seizures.
🤔 Common Patient Concerns
🔄 Substitutes for cfx o 100mg/100mg tablet
View AllAlternative brands with exact same active ingredient:
-
stayhappi cefixime+ofloxacin 100mg/100mg tabletSarvagunaushdhi Pvt Ltd ₹47.81 46.9% CHEAPER
-
crinux-o kid 100mg/100mg tabletPax Healthcare ₹55.50 38.3% CHEAPER
-
lufixcin 100mg/100mg tabletLupin Ltd ₹56.16 37.6% CHEAPER
-
vitor cx 100mg/100mg tabletMcastro Pharma ₹58.04 35.5% CHEAPER
-
cefo plus 100 mg/100 mg tabletMedley Pharmaceuticals ₹62.00 31.1% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections like the flu.
Fact: This medicine is effective only against bacterial infections. It does not treat viral infections. - Myth: You can stop taking this medicine once you feel better.
Fact: You must complete the full course as prescribed, even if symptoms improve, to prevent resistance and ensure complete eradication of bacteria. - Myth: This medicine is safe to take during pregnancy.
Fact: Ofloxacin, a component of this medicine, is not recommended during pregnancy due to potential risk to the fetus. Consult your doctor for alternatives.
🔄 Alternative Options
Generic Alternatives
- Cefixime 100 mg + Ofloxacin 100 mg tablet (generic)
Brand Alternatives
- Amicef O 100mg/100mg Tablet