Hepatitis B Vaccine (rDNA) 20mcg Injection: Complete Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or wheezing after the injection.
- Swelling of the face, lips, tongue, or throat.
- A widespread rash or hives with itching.
- A sudden drop in blood pressure or fainting.
- High fever that does not settle.
- Severe pain, swelling, or redness spreading from the injection site.
- Weakness, tingling, or paralysis in the limbs.
If experiencing severe symptoms, call emergency services immediately.
What is cefvac- b adult vaccine used for?
This medicine is a hepatitis B vaccine given by intramuscular injection to protect adults against hepatitis B infection. It works by helping the immune system produce antibodies against the virus. It is given as a series of doses, and full protection requires completing the schedule.
- Generic Name: Hepatitis B Vaccine (rDNA)
- Manufacturer: Cipla Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cefvac- b adult vaccine के बारे में (Hindi Summary)
उपयोग: यह दवा हेपेटाइटिस बी वायरस से बचाव के लिए दी जाने वाली वैक्सीन है। इसे इंजेक्शन के रूप में ऊपरी बांह की मांसपेशी में लगाया जाता है। यह शरीर की प्रतिरक्षा प्रणाली को हेपेटाइटिस बी वायरस के खिलाफ एंटीबॉडी बनाने के लिए प्रेरित करती है, जिससे भविष्य में इस संक्रमण से सुरक्षा मिलती है। यह उन वयस्कों के लिए है जिन्हें हेपेटाइटिस बी का खतरा अधिक है, जैसे स्वास्थ्यकर्मी, डायलिसिस मरीज, और संक्रमित व्यक्ति के संपर्क में आने वाले लोग। पूरी सुरक्षा के लिए सभी निर्धारित खुराकें समय पर लगवाना जरूरी है। यह वैक्सीन पहले से मौजूद हेपेटाइटिस बी संक्रमण का इलाज नहीं करती।
साइड इफेक्ट्स: इस वैक्सीन के बाद आमतौर पर हल्के दुष्प्रभाव ही होते हैं। इंजेक्शन वाली जगह पर दर्द, लालिमा या सूजन आ सकती है, जो आमतौर पर एक से तीन दिन में ठीक हो जाती है। कुछ लोगों को हल्का बुखार, सिरदर्द या थकान महसूस हो सकती है। गंभीर एलर्जी प्रतिक्रिया बहुत कम होती है, लेकिन अगर सांस लेने में तकलीफ, चेहरे या गले में सूजन, या तेज चकत्ते दिखें तो तुरंत डॉक्टर से मिलें। यह वैक्सीन हेपेटाइटिस बी नहीं फैलाती क्योंकि इसमें जीवित वायरस नहीं होता।
सुरक्षा सलाह: यह वैक्सीन केवल प्रशिक्षित स्वास्थ्यकर्मी द्वारा इंजेक्शन के रूप में लगाई जाती है, इसे खुद न लगाएं। टीका लगवाने से पहले डॉक्टर को अपनी सभी एलर्जी, बीमारियों और दवाओं के बारे में बताएं। अगर आप गर्भवती हैं, स्तनपान करा रही हैं या गर्भधारण की योजना बना रही हैं, तो डॉक्टर से सलाह लें। इंजेक्शन के बाद कम से कम 15 मिनट क्लिनिक में रुकें। टीके वाली जगह को रगड़ें नहीं। सभी निर्धारित खुराकें समय पर पूरी करें। अपने टीकाकरण का रिकॉर्ड रखें और हर बार डॉक्टर को दिखाएं।
💊 cefvac- b adult vaccine Uses & Benefits
[{"condition":"Prevention of hepatitis B infection","description":"This vaccine stimulates active immunity against hepatitis B virus, reducing the risk of acute and chronic liver disease.","evidence":"Well-established"},{"condition":"Prevention of hepatitis D infection","description":"Because hepatitis D virus requires hepatitis B virus to replicate, vaccination against hepatitis B also prevents hepatitis D.","evidence":"Well-established"},{"condition":"Prevention of hepatitis B-related cirrhosis and liver cancer","description":"Long-term protection against chronic hepatitis B reduces the risk of cirrhosis and hepatocellular carcinoma.","evidence":"Well-established"},{"condition":"Post-exposure prophylaxis in non-immune adults","description":"In certain exposure situations, this vaccine may be used together with hepatitis B immune globulin as advised by a clinician.","evidence":"Well-established"}]
Off-label uses: []
Primary treatment for: Hepatitis B infection
Also treats: Hepatitis D infection, Cirrhosis, Hepatocellular carcinoma
📋 Drug Information
| Generic Name(s) | Hepatitis B Vaccine (rDNA) |
| Brand Name | Cefvac-B Adult Vaccine |
| Manufacturer | Cipla Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | VACCINES |
| Action Class | Subunit (Purified antigen) |
| Route of Administration | Intramuscular injection, usually into the deltoid muscle of the upper arm in adults |
| Storage | Store this vaccine in a refrigerator at 2 to 8 degrees Celsius. Do not freeze. Keep it in the original packaging to protect it from light. Do not use if the vaccine has been frozen or if it appears discoloured or contains particles. |
| Shelf Life | The shelf life is typically 24 to 36 months from the date of manufacture when stored correctly at 2 to 8 degrees Celsius. Always check the expiry date on the label before use. |
| WHO Guideline | The World Health Organization recommends hepatitis B vaccination for all infants as part of routine immunization and for adults at increased risk of infection. The exact schedule and target groups may vary by country. This information is for general education and should be confirmed with local guidelines. |
| ICMR Guideline | The Indian Council of Medical Research supports hepatitis B vaccination for at-risk adults and children according to national immunization schedules. Healthcare workers and other high-risk groups should be vaccinated. Please consult your doctor for personalized advice. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine contains hepatitis B surface antigen produced by recombinant DNA technology. After intramuscular injection, the antigen is taken up by antigen-presenting cells and presented to the immune system. This activates helper T cells and B cells, leading to the production of specific antibodies against the hepatitis B surface antigen. The immune system also develops memory cells, so that future exposure to the real hepatitis B virus triggers a rapid and strong protective response. The vaccine does not contain live virus and therefore cannot cause hepatitis B infection.
Mechanism Steps
💡 How to Take cefvac- b adult vaccine
Strength: Injection containing 20 micrograms of hepatitis B surface antigen per dose.
Dosage Information
| Adult Dosage | For adults, this vaccine is given as a 20 microgram dose by intramuscular injection. The exact schedule depends on the indication and the doctor's recommendation. Common schedules include a three-dose series at 0, 1, and 6 months, or a two-dose series for certain products. The dose and schedule must be individualized by a qualified clinician based on the patient's age, immune status, risk factors, and any underlying medical conditions. Do not self-administer this vaccine. |
| Pediatric Dosage | Pediatric dosing is not established from available information for this adult strength. A pediatrician should be consulted for appropriate hepatitis B vaccination in children, as different strengths and schedules are used. |
| Elderly Dosage | The same 20 microgram dose is generally used in older adults. However, the immune response may be lower in elderly individuals, and antibody testing or additional doses may be considered by the doctor. The dose must be individualized by a qualified clinician. |
| Renal Impairment | No specific dose adjustment is required for this vaccine in people with kidney disease. However, individuals on dialysis or with advanced kidney disease may have a reduced immune response and may need additional doses or monitoring. The schedule should be determined by a qualified clinician. |
| Hepatic Impairment | No specific dose adjustment is required for this vaccine in people with liver disease. It is used to prevent hepatitis B infection, which can worsen liver disease. The decision to vaccinate should be made by a qualified clinician. |
| Maximum Daily Dose | Not applicable. This vaccine is not given daily. It is administered as a single dose per scheduled visit, and the total number of doses depends on the recommended series. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cefvac- b adult vaccine
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe allergic reaction to a previous dose of hepatitis B vaccine or to any component of this vaccine.","Known allergy to yeast, because the vaccine is produced using recombinant DNA technology in yeast cells.","Acute severe febrile illness at the time of vaccination; vaccination should be postponed until recovery.","This adult strength is not intended for infants or young children."]
⚠️ Warnings & Precautions
["This vaccine must be given by a qualified healthcare professional only.","Tell your doctor about any allergies, especially to yeast or latex, before receiving the vaccine.","People with a weakened immune system may have a reduced response to the vaccine.","The vaccine may not protect everyone who receives it; complete the full series for the best chance of protection.","Do not use this vaccine to treat an existing hepatitis B infection.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Keep a personal record of your vaccination dates and bring it to all medical appointments."]
🤱 Lactation Safety
This vaccine is generally considered safe during breastfeeding. It is not expected to harm the breastfed infant because the vaccine contains no live virus. Women who are breastfeeding and need protection against hepatitis B should discuss the timing with their doctor.
💊 Overdose Management
Overdose with this vaccine is unlikely because it is given as a single controlled injection by a healthcare professional. If more than the recommended dose is given accidentally, the patient should be monitored for any unusual reactions and treated symptomatically. There is no specific antidote. Contact a doctor or poison control centre if you have any concerns.
⏰ Missed Dose
If you miss a scheduled dose of this vaccine, contact your doctor or vaccination clinic as soon as possible to arrange the next dose. Do not try to catch up by taking extra doses on your own. The vaccination series should be completed according to the schedule recommended by your healthcare provider. In most cases, the series can be resumed without starting over, but your doctor will advise you on the best plan.
Additional Safety Advice
This medicine must be given by a trained healthcare professional as an intramuscular injection, usually into the upper arm muscle. Do not attempt to self-administer it. Before receiving the vaccine, tell your doctor if you have ever had a severe allergic reaction to a vaccine, if you are allergic to yeast, or if you have a fever or a serious illness at the time of your appointment. If you are pregnant, planning pregnancy, or breastfeeding, discuss the benefits and risks with your doctor. People with a weakened immune system, including those on dialysis or taking immunosuppressive medicines, may need additional doses or monitoring because their response to the vaccine may be reduced. Keep a record of your vaccination dates and bring it to every appointment. After the injection, remain in the clinic for at least 15 minutes so that any immediate reaction can be managed. Do not rub the injection site, and avoid heavy use of the arm for a few hours. Complete the full recommended series to ensure the best protection.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults can receive this vaccine, but the immune response may be lower than in younger people. Your doctor may consider antibody testing or additional doses. The dose and schedule should be individualized by a qualified clinician.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss hepatitis B vaccination with your doctor. It is generally considered safe during pregnancy when there is a clear need. Completing the series before pregnancy can provide protection for you and your baby.
🏥 Post-Surgery Considerations
There is no specific restriction on receiving this vaccine after surgery. However, if you are unwell or have a fever, your doctor may postpone vaccination until you have recovered. Follow your surgeon's and physician's advice.
🦷 Dental Procedures
There is no direct interaction between this vaccine and dental procedures. Inform your dentist about your vaccination status and any medicines you are taking. Standard infection control practices should be followed during dental work.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
There is no specific exercise restriction after receiving this vaccine. If you feel tired or have a mild fever, take it easy for the rest of the day. You can resume your normal exercise routine when you feel well.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This vaccine does not usually affect your ability to work or drive. Some people may feel mild tiredness or soreness in the arm after the injection. If you feel unwell, rest and avoid driving or operating heavy machinery until you feel better.
🛑 When to Stop This Medicine
This vaccine is given as a limited series, so there is no need to stop it in the usual sense. If you experience a severe allergic reaction or another serious side effect, do not receive further doses and seek medical advice immediately. Always consult your doctor before deciding to stop the vaccination series.
📅 Long-Term Use Effects
Long-term use is not applicable because this vaccine is given as a limited series of doses, not as a daily medicine. The long-term benefit is protection against hepatitis B infection, which reduces the risk of chronic liver disease, cirrhosis, and liver cancer. In healthy individuals, protection can last for many years. People with weakened immune systems may need additional doses or monitoring. There are no known long-term harmful effects from receiving the vaccine as recommended.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A combination vaccine that protects against both hepatitis A and hepatitis B in a single series.
Evidence: Well-establishedUsed for immediate post-exposure protection in non-immune individuals, often together with the vaccine.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This vaccine can be given at the same time as other vaccines, but they should be administered at different injection sites using separate syringes. Inform your doctor about all vaccines you have recently received or plan to receive. If you are scheduled for other vaccinations, your doctor will advise on the best timing.
📦 Storage Guide
✅ DO
Store in a refrigerator at 2 to 8 degrees Celsius.
❌ DON'T
Do not freeze the vaccine.
✅ DO
Keep the vaccine in its original packaging to protect it from light.
❌ DON'T
Do not transfer it to unmarked containers.
✅ DO
Check the expiry date before use.
❌ DON'T
Do not use if the vaccine appears discoloured or contains particles.
✈️ Traveling with This Medicine
If you are travelling, carry your vaccination record and a copy of your prescription in your hand luggage. This vaccine is given by a healthcare professional, so plan your doses around your travel dates. Store the vaccine at 2 to 8 degrees Celsius if you are carrying it, and never freeze it. Check customs regulations for carrying medical products across borders. If you are travelling to a region where hepatitis B is common, ensure you have completed the recommended series before departure.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Antibodies begin to develop within a few weeks after the first dose, but full protection is expected only after completing the recommended series. Your doctor can advise you on the exact schedule.
A: No. The vaccine contains no live virus, so it cannot cause hepatitis B infection.
A: Hepatitis B vaccination is generally considered safe during pregnancy when there is a clear need. Discuss the benefits and risks with your doctor.
A: Protection can last for many years, often decades, after a complete series in healthy individuals. Booster doses may be considered for certain high-risk groups based on antibody testing and clinical advice.
A: The most common side effects are soreness, redness, or swelling at the injection site, mild fever, headache, and tiredness. These usually settle within a few days.
🤔 Common Patient Concerns
🔄 Substitutes for cefvac- b adult vaccine
View AllAlternative brands with exact same active ingredient:
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bevac 20mcg injectionBiological E Ltd ₹47.50 52.5% CHEAPER
-
genevac-b adult vaccineSerum Institute Of India Ltd ₹82.76 17.2% CHEAPER
-
shanvac-b 20mcg vaccineSanofi India Ltd ₹106.14 6.1% COSTLIER
-
hepashield 20mcg vaccinePfizer Ltd ₹152.70 52.7% COSTLIER
-
elovac-b 20mcg injectionIndian Immunologicals Ltd ₹162.50 62.5% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: The hepatitis B vaccine can cause hepatitis B.
Fact: The vaccine contains no live virus, so it cannot cause hepatitis B infection. - Myth: Once you get the first dose, you are fully protected.
Fact: Full protection usually requires completing the entire recommended series of doses. - Myth: The vaccine is only for children.
Fact: Adults at risk of hepatitis B also need vaccination, and this adult formulation is designed for them. - Myth: The vaccine weakens the immune system.
Fact: The vaccine strengthens immunity against hepatitis B by training the immune system to recognize and fight the virus.
🔄 Alternative Options
Brand Alternatives
- Engerix-B
- Recombivax HB
- Gene Vac-B
- Shanvac-B