cefsafe cv tablet - Uses, Price, Side Effects & Substitutes
What is cefsafe cv tablet used for?
Augxetil CV 500 Tablet (Cefuroxime + Clavulanic Acid) is used to treat ANTI INFECTIVES. It contains Cefuroxime (500mg) + Clavulanic Acid (125mg), which Cefuroxime inhibits bacterial cell wall synthesis by binding to penicillin-bindi. Always consult your doctor before use. Take as prescribed.
- Generic Name: Cefuroxime + Clavulanic Acid
- Manufacturer: Khandelwal Laboratories Pvt Ltd
- Form: Allopathy
- Pregnancy Category: B
- Prescription Required: Yes
๐ cefsafe cv tablet Uses & Benefits
Upper and lower respiratory tract infections, urinary tract infections, skin and soft tissue infections, otitis media, sinusitis, bone and joint infections.
Off-label uses: Lyme disease, gonorrhea, surgical prophylaxis (oral form not typically used).
๐ Drug Information
| Generic Name(s) | Cefuroxime + Clavulanic Acid |
| Brand Name | Augxetil CV 500 Tablet |
| Manufacturer | Khandelwal Laboratories Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporin antibiotic + Beta-lactamase inhibitor |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC); protect from moisture and light. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Cefuroxime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs); Clavulanic acid irreversibly inhibits beta-lactamases, preventing degradation of cefuroxime.
Mechanism Steps
๐ก How to Take cefsafe cv tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of cefsafe cv tablet
โ Common Side Effects
- Diarrhea
- Nausea
- Vomiting
- Rash
- Injection site pain (if IV)
๐จ Serious Side Effects
- Severe allergic reactions
- Clostridioides difficile colitis
- Seizures
- Stevens-Johnson syndrome
โ ๏ธ Rare Side Effects
- Hemolytic anemia
- Interstitial nephritis
- Hepatitis
- Agranulocytosis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased INR and bleeding risk |
| Methotrexate | Major | Increased methotrexate toxicity |
| Probenecid | Major | Decreased renal excretion of cefuroxime |
| Live vaccines | Major | Reduced vaccine efficacy |
| Oral contraceptives | Moderate | Reduced contraceptive efficacy |
| Loop diuretics | Moderate | Increased nephrotoxicity risk |
| Aminoglycosides | Moderate | Additive nephrotoxicity |
| Antacids | Minor | Reduced absorption |
| H2 receptor antagonists | Minor | Reduced absorption |
๐จ Major Interactions
- Warfarin
- Methotrexate
- Probenecid
- Live vaccines
โก Moderate Interactions
- Oral contraceptives
- Loop diuretics
- Aminoglycosides
โน๏ธ Minor Interactions
- Antacids
- H2 receptor antagonists
๐ฝ๏ธ Food Interactions
Food increases absorption; take with food to enhance bioavailability.
๐ท Alcohol Interaction
No direct interaction, but alcohol may increase side effects like dizziness.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to cephalosporins or beta-lactamase inhibitors; history of anaphylaxis to penicillins.
๐ Monitoring Parameters
Renal function, liver function, CBC, signs of superinfection or allergic reactions.
๐คฑ Lactation Safety
Excreted in breast milk in small amounts; use with caution.
๐ Overdose Management
Supportive care; hemodialysis may enhance elimination.
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose. Do not double dose.