cefosys forte 500mg/250mg injection - Uses, Price, Side Effects & Substitutes
What is cefosys forte 500mg/250mg injection used for?
Augtax 1000 mg/500 mg Injection (Cefotaxime + Sulbactam) is used to treat ANTI INFECTIVES. It contains Cefotaxime (500mg) + Sulbactam (250mg), which Cefotaxime inhibits bacterial cell wall synthesis by binding to penicillin-bindi. Always consult your doctor before use. Take as prescribed.
- Generic Name: Cefotaxime + Sulbactam
- Manufacturer: Systacare Remedies
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ cefosys forte 500mg/250mg injection Uses & Benefits
Treatment of respiratory tract infections, urinary tract infections, intra-abdominal infections, septicemia, meningitis, bone and joint infections, skin and soft tissue infections
Off-label uses: Surgical prophylaxis, Febrile neutropenia, Lyme disease
๐ Drug Information
| Generic Name(s) | Cefotaxime + Sulbactam |
| Brand Name | Augtax 1000 mg/500 mg Injection |
| Manufacturer | Systacare Remedies |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporin + Beta-lactamase inhibitor |
| Route of Administration | Intravenous (IV) or intramuscular (IM) |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light; reconstituted solution stable for 24 hours at room temperature, 48 hours under refrigeration |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Cefotaxime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs); Sulbactam irreversibly inhibits beta-lactamases, preventing degradation of cefotaxime
Mechanism Steps
๐ก How to Take cefosys forte 500mg/250mg injection
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of cefosys forte 500mg/250mg injection
โ Common Side Effects
- Diarrhea
- Nausea
- Vomiting
- Rash
- Injection site pain
- Phlebitis
๐จ Serious Side Effects
- Anaphylaxis
- Clostridioides difficile colitis
- Seizures
- Stevens-Johnson syndrome
- Hemolytic anemia
- Acute renal failure
โ ๏ธ Rare Side Effects
- Agranulocytosis
- Thrombocytopenia
- Interstitial nephritis
- Hepatitis
- Pseudomembranous colitis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased INR and bleeding risk |
| Probenecid | Major | Decreased renal excretion of cefotaxime, increased toxicity |
| Aminoglycosides | Major | Increased nephrotoxicity risk |
| Loop diuretics | Major | Increased nephrotoxicity risk |
| Oral contraceptives | Moderate | Reduced contraceptive efficacy |
| BCG vaccine | Moderate | Reduced vaccine efficacy |
| Typhoid vaccine | Moderate | Reduced vaccine efficacy |
| Antacids | Minor | No significant interaction (IV) |
| Iron supplements | Minor | No significant interaction (IV) |
๐จ Major Interactions
- Warfarin
- Probenecid
- Aminoglycosides
- Loop diuretics
โก Moderate Interactions
- Oral contraceptives
- BCG vaccine
- Typhoid vaccine
โน๏ธ Minor Interactions
- Antacids
- Iron supplements
๐ฝ๏ธ Food Interactions
No significant food interactions (IV administration)
๐ท Alcohol Interaction
May cause disulfiram-like reaction (avoid alcohol during and up to 72 hours after treatment)
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to cephalosporins, penicillins, or beta-lactamase inhibitors; history of severe allergic reactions
๐ Monitoring Parameters
Renal function, liver function, CBC, signs of superinfection, hypersensitivity reactions
๐คฑ Lactation Safety
Excreted in breast milk in low amounts; use with caution
๐ Overdose Management
Supportive care; hemodialysis may enhance elimination
โฐ Missed Dose
Administer as soon as remembered; do not double dose