Accuzon Plus 250 mg/125 mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat
- Severe or persistent diarrhea, or diarrhea with blood or mucus
- Signs of a severe skin reaction such as painful rash, blistering, or peeling
- Unusual bleeding or bruising
- Yellowing of the skin or eyes, dark urine, or severe abdominal pain
- Decreased urine output or swelling in the legs
- Seizures or severe confusion
If experiencing severe symptoms, call emergency services immediately.
What is cefika s 250 mg/125 mg injection used for?
This medicine is a combination antibiotic containing ceftriaxone and sulbactam, used intravenously to treat serious bacterial infections. It works by killing bacteria and preventing their growth.
- Generic Name: Ceftriaxone + Sulbactam
- Manufacturer: Stadchem Of India
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cefika s 250 mg/125 mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा सेफ्ट्रिएक्सोन और सल्बैक्टम का संयोजन है, जिसका उपयोग गंभीर जीवाणु संक्रमणों के इलाज के लिए अंतःशिरा (IV) मार्ग से किया जाता है। यह निमोनिया, मूत्र पथ के संक्रमण, त्वचा संक्रमण, पेट के अंदर के संक्रमण, मेनिनजाइटिस और गोनोरिया जैसी बीमारियों के इलाज में प्रभावी है। यह दवा केवल डॉक्टर की देखरेख में अस्पताल में दी जाती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन स्थल पर दर्द, दस्त, मतली, उल्टी और त्वचा पर चकत्ते शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी प्रतिक्रिया, गंभीर दस्त, रक्त विकार और यकृत एंजाइम में वृद्धि हो सकती है। यदि सांस लेने में कठिनाई, चेहरे या गले में सूजन, या गंभीर दस्त हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल स्वास्थ्य पेशेवर द्वारा अस्पताल में दी जानी चाहिए। स्वयं इंजेक्शन न लगाएं। अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों और एलर्जी के बारे में बताएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। शराब का सेवन न करें। संक्रमण के पूरी तरह ठीक होने तक दवा का पूरा कोर्स पूरा करें।
💊 cefika s 250 mg/125 mg injection Uses & Benefits
[{"condition":"Community-acquired pneumonia","description":"Used for the treatment of moderate to severe community-acquired pneumonia caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Complicated urinary tract infections","description":"Effective against complicated urinary tract infections, including pyelonephritis, caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Used for serious skin and soft tissue infections such as cellulitis and abscesses requiring intravenous therapy.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Prescribed for intra-abdominal infections like peritonitis and intra-abdominal abscesses, often in combination with other antibiotics.","evidence":"Well-established"},{"condition":"Bacterial meningitis","description":"Used as part of empiric therapy for bacterial meningitis in adults and children.","evidence":"Well-established"},{"condition":"Gonorrhea","description":"Effective for the treatment of uncomplicated gonorrhea caused by susceptible strains of Neisseria gonorrhoeae.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Lyme disease","description":"Sometimes used off-label for the treatment of early disseminated Lyme disease in patients who cannot take doxycycline.","evidence":"Limited"},{"condition":"Typhoid fever","description":"May be used off-label for the treatment of typhoid fever caused by Salmonella typhi, though resistance patterns vary.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Pneumonia, Urinary tract infections, Skin infections, Intra-abdominal infections, Meningitis, Gonorrhea
📋 Drug Information
| Generic Name(s) | Ceftriaxone + Sulbactam |
| Brand Name | Accuzon Plus 1.5gm Injection |
| Manufacturer | Stadchem Of India |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporin + Beta-lactamase inhibitor |
| Route of Administration | Intravenous (IV) administration. The medicine is given as a slow intravenous injection or infusion over 2-4 minutes (for direct injection) or 30 minutes (for infusion) |
| Storage | Store the unreconstituted powder at room temperature (20-25°C). After reconstitution, the solution should be used immediately or stored as per the manufacturer's instructions, typically refrigerated (2-8°C) and used within 24 hours. Protect from light and moisture. |
| Shelf Life | The shelf life of the unreconstituted powder is typically 24-36 months from the date of manufacture. Check the expiry date on the packaging. Once reconstituted, use within the time specified by the manufacturer. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines ceftriaxone, a third-generation cephalosporin antibiotic, with sulbactam, a beta-lactamase inhibitor. Ceftriaxone inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to bacterial cell death. Sulbactam irreversibly inhibits certain beta-lactamase enzymes produced by bacteria, thereby protecting ceftriaxone from enzymatic degradation and extending its spectrum of activity against beta-lactamase-producing organisms.
Mechanism Steps
💡 How to Take cefika s 250 mg/125 mg injection
Strength: 250 mg ceftriaxone and 125 mg sulbactam per vial, for intravenous administration.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 250 mg/125 mg administered intravenously every 6 to 8 hours, or as prescribed by the physician. For severe infections, higher doses may be used. The dose and duration must be individualized by a qualified clinician based on the type and severity of infection, renal and hepatic function, and clinical response. Do not self-administer; this medicine should only be given by a healthcare professional. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may have reduced renal function, which can affect the elimination of ceftriaxone and sulbactam. Dose adjustment may be necessary based on renal function. Monitor closely for signs of toxicity. |
| Renal Impairment | In patients with renal impairment, dose adjustment of sulbactam is required. Ceftriaxone dose adjustment is usually not necessary unless both renal and hepatic impairment are present. Consult a clinician for individualized dosing. |
| Hepatic Impairment | In patients with hepatic impairment, ceftriaxone dose adjustment may be needed if there is concomitant renal impairment. Monitor liver function. Sulbactam dose adjustment is not typically required for hepatic impairment alone. |
| Maximum Daily Dose | The maximum daily dose should be determined by a qualified clinician based on the patient's condition and renal function. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cefika s 250 mg/125 mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Calcium-containing IV solutions | Major | |
| Warfarin | Major | |
| Aminoglycosides | Major | |
| Loop diuretics | Moderate | |
| Probenecid | Moderate | |
| Oral contraceptives | Minor |
🚨 Major Interactions
- Calcium-containing intravenous solutions
- Warfarin
- Aminoglycosides
⚡ Moderate Interactions
- Loop diuretics (e.g., furosemide)
- Probenecid
🍷 Alcohol Interaction
Alcohol should be avoided while receiving this medicine. It may increase the risk of liver toxicity and can exacerbate side effects such as nausea and dizziness. Additionally, alcohol can weaken the immune system and slow recovery from infection.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to ceftriaxone, sulbactam, or any other cephalosporin or beta-lactam antibiotic.","Previous serious allergic reaction to penicillins or cephalosporins.","Concomitant use with calcium-containing intravenous solutions in neonates (28 days or younger).","Hyperbilirubinemic neonates, especially premature infants."]
⚠️ Warnings & Precautions
["Serious and occasionally fatal hypersensitivity reactions can occur. Before therapy, inquire about previous hypersensitivity to penicillins, cephalosporins, or other allergens.","Clostridioides difficile-associated diarrhea may occur; consider this diagnosis in patients who develop diarrhea during or after treatment.","Use with caution in patients with renal impairment; dose adjustment may be necessary.","Use with caution in patients with hepatic impairment; monitor liver function.","May cause false-positive results in certain urine glucose tests and Coombs tests.","Prolonged use may result in overgrowth of non-susceptible organisms; monitor for superinfections.","In patients with a history of seizures or risk factors, use with caution as ceftriaxone may precipitate seizures."]
🤱 Lactation Safety
Ceftriaxone and sulbactam are excreted in human breast milk in low concentrations. Caution should be exercised when administered to a nursing woman. Consult your doctor to weigh the benefits and risks.
💊 Overdose Management
Overdosage of this medicine may cause symptoms such as nausea, vomiting, diarrhea, and seizures. There is no specific antidote. Treatment should be symptomatic and supportive. In cases of severe overdose, hemodialysis may be considered, but it is not effective for ceftriaxone due to high protein binding. Contact a poison control center or emergency department immediately if overdose is suspected.
⏰ Missed Dose
Since this medicine is administered by a healthcare professional, missed doses are unlikely. If you miss a scheduled dose, contact your healthcare provider as soon as possible. Do not attempt to self-administer a double dose.
Additional Safety Advice
This medicine must be administered by a healthcare professional in a clinical setting. Do not attempt to self-administer. Inform your doctor about all your medical conditions, especially kidney or liver disease, and any allergies to antibiotics. Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Avoid alcohol while receiving this medicine as it may increase the risk of certain side effects. Complete the full course as prescribed, even if you feel better, to prevent the development of antibiotic resistance. Do not share this medicine with others.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced renal function, which can affect the elimination of this medicine. Dose adjustment may be necessary. Monitor closely for signs of toxicity, such as confusion or seizures.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before starting this medicine. It is classified as Pregnancy Category B, but use only if clearly needed. Effective contraception is recommended during treatment if you are of childbearing age.
🏥 Post-Surgery Considerations
This medicine may be used to prevent or treat surgical site infections. If you have recently had surgery, inform your surgeon about any allergies and follow their instructions regarding antibiotic use.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine, as it may interact with other medications or affect your dental treatment. Good oral hygiene is important during antibiotic therapy.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While recovering from a serious infection, avoid strenuous exercise. Light activity such as walking is encouraged once you feel up to it. Consult your doctor before resuming intense workouts.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital setting, so you will likely need to take time off work during treatment. You may experience fatigue and dizziness; avoid driving or operating heavy machinery until you feel fully recovered. Discuss with your employer about sick leave.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Complete the full course as prescribed, even if you feel better, to prevent recurrence of infection and antibiotic resistance. If you experience severe side effects, contact your doctor immediately; they will decide whether to stop or change the treatment.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to overgrowth of non-susceptible organisms, including fungi, which may require additional treatment. Prolonged therapy may also increase the risk of liver enzyme elevations and blood dyscrasias. Regular monitoring of liver and kidney function, as well as complete blood counts, is recommended during extended use. Discontinue if severe adverse effects occur, as advised by your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For less severe infections, oral antibiotics may be used instead of intravenous therapy.
Evidence: Well-establishedDepending on the causative organism and susceptibility, other antibiotics may be more appropriate.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, antibiotics may reduce the effectiveness of live bacterial vaccines (e.g., typhoid vaccine). Consult your doctor regarding vaccination timing.
📦 Storage Guide
✅ DO
Store the unreconstituted powder at room temperature (20-25°C)
❌ DON'T
Do not freeze the powder
✅ DO
After reconstitution, use immediately or refrigerate (2-8°C) and use within 24 hours
❌ DON'T
Do not use if the solution is cloudy or contains particles
✅ DO
Keep in original packaging
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
This medicine is administered in a healthcare setting, so travel advice is limited. If you are traveling after treatment, carry a copy of your prescription and medical records. Store any remaining medication as instructed, and declare it at customs if required. Consult your doctor before traveling if you have ongoing infection symptoms.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24-48 hours, but it is important to complete the full course as prescribed.
A: This medicine may cause dizziness. Avoid driving or operating machinery until you know how it affects you.
A: It is classified as Pregnancy Category B. Use only if clearly needed and prescribed by your doctor.
A: Since it is given by a healthcare professional, missed doses are unlikely. If you miss a dose, inform your doctor immediately.
🤔 Common Patient Concerns
🔄 Substitutes for cefika s 250 mg/125 mg injection
View AllAlternative brands with exact same active ingredient:
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monomac 250 mg/125 mg injectionMac Laboratories Ltd ₹18.02 57% CHEAPER
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biocef-s 375 injectionLeeford Healthcare Ltd ₹18.16 56.7% CHEAPER
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citizone sl 250mg/125mg injectionSymbiosis Life Sciences Limited ₹27.00 35.6% CHEAPER
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cifigold 375 injectionPharmasynth Formulations Ltd ₹32.00 23.7% CHEAPER
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ceftichek 250mg/125mg injectionIndoco Remedies Ltd ₹32.55 22.4% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections like the flu.
Fact: This medicine is an antibiotic and is only effective against bacterial infections. It does not treat viral infections. - Myth: You can stop taking this medicine once you feel better.
Fact: It is important to complete the full course as prescribed to prevent the infection from returning and to reduce the risk of antibiotic resistance.
🔄 Alternative Options
Generic Alternatives
- Ceftriaxone and sulbactam generic injections
Brand Alternatives
- Other brands containing ceftriaxone and sulbactam