capreo 500mg injection - Uses, Price, Side Effects & Substitutes
What is capreo 500mg injection used for?
Ciprix (Capreomycin) is used to treat ANTI INFECTIVES. It contains Capreomycin (500mg), which Inhibits protein synthesis by binding to the 30S ribosomal subunit, causing misr. Always consult your doctor before use. Take as prescribed.
- Generic Name: Capreomycin
- Manufacturer: Concept Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ capreo 500mg injection Uses & Benefits
Second-line treatment of tuberculosis (multidrug-resistant TB) in combination with other antitubercular agents.
Off-label uses: Treatment of infections caused by other mycobacteria (e.g., M. kansasii)
๐ Drug Information
| Generic Name(s) | Capreomycin |
| Brand Name | Ciprix |
| Manufacturer | Concept Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Aminoglycosides |
| Route of Administration | Intramuscular (deep IM) or intravenous (IV) infusion. |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light; reconstituted solution stable for 24 hours at room temperature. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Inhibits protein synthesis by binding to the 30S ribosomal subunit, causing misreading of mRNA and preventing peptide chain elongation.
Mechanism Steps
๐ก How to Take capreo 500mg injection
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of capreo 500mg injection
โ Common Side Effects
- Nephrotoxicity (increased creatinine, proteinuria)
- Ototoxicity (tinnitus, hearing loss)
- Vestibular toxicity (dizziness, vertigo)
- Pain at injection site
- Eosinophilia
๐จ Serious Side Effects
- Acute renal failure
- Irreversible hearing loss
- Neuromuscular blockade (respiratory depression)
- Anaphylaxis
- Stevens-Johnson syndrome
โ ๏ธ Rare Side Effects
- Hepatotoxicity
- Blood dyscrasias (leukopenia, thrombocytopenia)
- Hypokalemia
- Hypomagnesemia
- Peripheral neuropathy
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Aminoglycosides | Major | Increased risk of nephrotoxicity and ototoxicity |
| Amphotericin B | Major | Increased risk of nephrotoxicity |
| Cisplatin | Major | Increased risk of nephrotoxicity and ototoxicity |
| Cyclosporine | Major | Increased risk of nephrotoxicity |
| Furosemide | Major | Increased risk of ototoxicity |
| Mannitol | Major | Increased risk of nephrotoxicity |
| NSAIDs | Major | Increased risk of nephrotoxicity |
| Tacrolimus | Major | Increased risk of nephrotoxicity |
| Vancomycin | Major | Increased risk of nephrotoxicity and ototoxicity |
| Neuromuscular blocking agents | Moderate | Enhanced neuromuscular blockade |
| Anesthetics | Moderate | Enhanced neuromuscular blockade |
| Anticholinesterases | Moderate | Antagonism of neuromuscular blockade reversal |
| Magnesium sulfate | Moderate | Enhanced neuromuscular blockade |
| Polymyxins | Moderate | Increased risk of nephrotoxicity and neuromuscular blockade |
| Penicillins | Minor | Possible inactivation in vitro, but clinical significance minimal |
| Cephalosporins | Minor | Possible inactivation in vitro, but clinical significance minimal |
๐จ Major Interactions
- Aminoglycosides
- Amphotericin B
- Cisplatin
- Cyclosporine
- Furosemide
- Mannitol
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
- Tacrolimus
- Vancomycin
โก Moderate Interactions
- Neuromuscular blocking agents
- Anesthetics
- Anticholinesterases
- Magnesium sulfate
- Polymyxins
โน๏ธ Minor Interactions
- Penicillins
- Cephalosporins
๐ฝ๏ธ Food Interactions
No significant food interactions.
๐ท Alcohol Interaction
Avoid alcohol; may increase risk of hepatotoxicity and dizziness.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to capreomycin or any aminoglycoside; pre-existing hearing loss; myasthenia gravis; severe renal impairment.
๐ Monitoring Parameters
Renal function (serum creatinine, BUN), audiometry, vestibular function, serum drug levels (if available), electrolytes, liver function tests.
๐คฑ Lactation Safety
Not recommended; excreted in breast milk in small amounts, risk of infant toxicity.
๐ Overdose Management
Supportive care; hemodialysis may enhance elimination; monitor renal function, hearing, and neuromuscular status.
โฐ Missed Dose
Administer as soon as remembered; if close to next dose, skip missed dose; do not double dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for capreo 500mg injection
View AllAlternative brands with exact same active ingredient (Capreomycin (500mg)):
-
ciprix 500mg injectionNeon Laboratories Ltd โน136.88 15% COSTLIER
-
kapocin 500mg injectionMacleods Pharmaceuticals Pvt Ltd โน246.00 106.7% COSTLIER
Medical Note: Always consult your doctor before switching medications.