Accuzon Plus 500 mg/250 mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of face, lips, or throat
- Severe or bloody diarrhea
- Rash with blisters or peeling skin
- High fever with chills
- Decreased urine output
- Yellowing of skin or eyes
- Seizures
If experiencing severe symptoms, call emergency services immediately.
What is camotri s 500mg/250mg injection used for?
This medicine is a combination antibiotic injection containing ceftriaxone and sulbactam. It is used to treat serious bacterial infections. It works by killing bacteria and preventing their growth. It is given intravenously by a healthcare professional.
- Generic Name: Ceftriaxone + Sulbactam
- Manufacturer: Lxir Medilabs Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 camotri s 500mg/250mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा सेफ्ट्रिएक्सोन और सल्बैक्टम का संयोजन है, जिसका उपयोग गंभीर जीवाणु संक्रमणों के इलाज के लिए किया जाता है। यह निमोनिया, मूत्र मार्ग संक्रमण, पेट के अंदर के संक्रमण, त्वचा संक्रमण, मेनिनजाइटिस और सेप्सिस जैसी बीमारियों में प्रभावी है। यह दवा केवल अस्पताल में डॉक्टर या नर्स द्वारा नस के माध्यम से दी जाती है। यह वायरल संक्रमण जैसे सर्दी-जुकाम के लिए प्रभावी नहीं है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन स्थल पर दर्द, लालिमा, दस्त, मतली, उल्टी, दाने और सिरदर्द शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी, गंभीर दस्त, त्वचा पर गंभीर प्रतिक्रियाएं, रक्त विकार और यकृत एंजाइम में वृद्धि हो सकती है। किसी भी असामान्य लक्षण को तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्य पेशेवर की देखरेख में ही दी जानी चाहिए। अपने डॉक्टर को अपनी सभी एलर्जी, गुर्दे या यकृत की बीमारी के बारे में बताएं। उपचार के दौरान शराब का सेवन न करें। यदि आपको गंभीर दस्त, पेट में ऐंठन या बुखार हो, तो तुरंत डॉक्टर से संपर्क करें। इस दवा को दूसरों के साथ साझा न करें।
💊 camotri s 500mg/250mg injection Uses & Benefits
[{"condition":"Community-acquired pneumonia","description":"Used for moderate to severe community-acquired pneumonia requiring hospitalization, especially when resistant organisms are suspected.","evidence":"Well-established"},{"condition":"Complicated urinary tract infections","description":"Effective against many Gram-negative bacteria causing pyelonephritis and complicated UTIs.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Used in combination with other agents for intra-abdominal infections like peritonitis and abscesses.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats severe cellulitis, abscesses, and wound infections caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Bacterial meningitis","description":"Ceftriaxone is a first-line agent for bacterial meningitis in many settings; sulbactam may extend coverage.","evidence":"Well-established"},{"condition":"Sepsis","description":"Empiric therapy for sepsis of unknown origin pending culture results.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Gonorrhea","description":"Ceftriaxone is standard; sulbactam combination may be used in some regions though not FDA-approved for this indication.","evidence":"Limited"},{"condition":"Lyme disease","description":"Ceftriaxone is used for disseminated Lyme disease; sulbactam addition is not standard.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Pneumonia, Urinary tract infections, Intra-abdominal infections, Skin infections, Meningitis, Sepsis
📋 Drug Information
| Generic Name(s) | Ceftriaxone + Sulbactam |
| Brand Name | Accuzon Plus 1.5gm Injection |
| Manufacturer | Lxir Medilabs Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporin + Beta-lactamase inhibitor |
| Route of Administration | Intravenous (IV) injection or infusion. It must be administered by a qualified healthcare professional |
| Storage | Store the unopened vial at room temperature between 20°C and 25°C (68°F to 77°F). Protect from light and moisture. Once reconstituted, the solution should be used immediately or stored as per the manufacturer's instructions, typically refrigerated and used within 24 hours. |
| Shelf Life | The shelf life is typically 24 months from the date of manufacture when stored as directed. Check the expiry date on the vial before use. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients. Ceftriaxone is a third-generation cephalosporin that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to inhibition of peptidoglycan cross-linking and bacterial lysis. Sulbactam is a beta-lactamase inhibitor that irreversibly binds to and inactivates many beta-lactamase enzymes produced by bacteria, thereby protecting ceftriaxone from enzymatic degradation and extending its spectrum of activity against beta-lactamase-producing organisms.
Mechanism Steps
💡 How to Take camotri s 500mg/250mg injection
Strength: Injection: 500 mg ceftriaxone + 250 mg sulbactam per vial.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 1.5 g (500 mg ceftriaxone + 250 mg sulbactam) to 3 g (1000 mg ceftriaxone + 500 mg sulbactam) administered intravenously every 12 hours, depending on the severity and type of infection. For severe infections, higher doses may be used. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Treatment duration varies from 5 to 14 days or longer for complicated infections. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may have reduced renal function; dose should be adjusted based on creatinine clearance. No specific dose adjustments are recommended solely based on age, but close monitoring is advised. |
| Renal Impairment | In patients with creatinine clearance less than 30 mL/min, the dose of sulbactam should be adjusted. Ceftriaxone does not require adjustment in renal impairment alone, but in combined renal and hepatic impairment, dose reduction may be necessary. Consult a clinician for individualized dosing. |
| Hepatic Impairment | In patients with severe hepatic impairment, ceftriaxone elimination may be prolonged. Dose adjustment may be required, especially if renal function is also impaired. Monitor liver function closely. |
| Maximum Daily Dose | The maximum recommended daily dose is 4 g of ceftriaxone (not to exceed) and 2 g of sulbactam, but individual dosing must be determined by a clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of camotri s 500mg/250mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Calcium-containing IV solutions | Major | |
| Warfarin | Major | |
| Aminoglycosides | Moderate | |
| Loop diuretics | Moderate | |
| Probenecid | Moderate | |
| Oral contraceptives | Minor | |
| Methotrexate | Minor |
🚨 Major Interactions
- Calcium-containing IV solutions (e.g., Ringer's lactate)
- Warfarin
- Aminoglycosides (e.g., gentamicin)
⚡ Moderate Interactions
- Loop diuretics (e.g., furosemide)
- Probenecid
🍷 Alcohol Interaction
Alcohol should be avoided while receiving this medicine because it may increase the risk of liver toxicity and could cause a disulfiram-like reaction (flushing, nausea, vomiting, headache).
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe hypersensitivity to ceftriaxone, sulbactam, or other beta-lactam antibiotics","History of anaphylaxis to penicillins or cephalosporins","Concomitant use with calcium-containing IV solutions in neonates (≤28 days)","Hyperbilirubinemic neonates","Neonates requiring IV calcium-containing solutions"]
⚠️ Warnings & Precautions
["Serious hypersensitivity reactions, including anaphylaxis, can occur. Discontinue immediately if suspected.","Clostridioides difficile-associated diarrhea may occur; monitor for severe diarrhea.","Use with caution in patients with renal impairment; dose adjustment may be needed.","May cause gallbladder sludge or pseudolithiasis; usually reversible upon discontinuation.","Prolonged use may lead to overgrowth of non-susceptible organisms.","Not effective against viral infections.","Should be prescribed only by a qualified healthcare professional."]
🤱 Lactation Safety
Ceftriaxone and sulbactam are excreted in human breast milk in low concentrations. Caution is advised when administering to a nursing mother. Consult your doctor to weigh the benefits and potential risks.
💊 Overdose Management
Overdose of this medicine is unlikely due to its parenteral administration by healthcare professionals. In case of accidental overdose, treatment should be symptomatic and supportive. Ceftriaxone and sulbactam are not significantly removed by hemodialysis or peritoneal dialysis. Monitor vital signs and provide supportive care.
⏰ Missed Dose
This medicine is administered by a healthcare professional in a hospital or clinic setting. If you miss a scheduled dose, contact your healthcare provider immediately to reschedule. Do not attempt to self-administer a double dose.
Additional Safety Advice
This medicine must be given only under the supervision of a qualified healthcare professional. Inform your doctor about all your allergies, especially to penicillins or cephalosporins, and any history of kidney or liver disease. Do not use this medicine if the vial is cracked, the solution is discolored, or particles are present. During treatment, your doctor may monitor your kidney and liver function, blood counts, and signs of superinfection. Avoid alcohol while receiving this medicine. If you experience severe diarrhea, abdominal cramps, or fever during or after treatment, contact your doctor immediately, as this could be a sign of a serious intestinal infection. Do not share this medicine with others, even if they have similar symptoms.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced renal function and may require dose adjustments. Monitor renal function closely and watch for signs of toxicity.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before using this medicine. It is classified as Pregnancy Category B, but use only if clearly needed.
🏥 Post-Surgery Considerations
This medicine may be used to prevent or treat surgical site infections. Follow your surgeon's instructions regarding dosing and duration.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine. It may be used prophylactically for dental procedures in patients at risk of infective endocarditis, but consult your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While receiving this medicine, you may feel tired or dizzy. Avoid strenuous exercise until you feel fully recovered. Consult your doctor before resuming intense physical activity.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a healthcare setting, so you may need to take time off work or arrange for transportation. You may experience fatigue or dizziness; avoid driving or operating machinery until you know how the medicine affects you.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Stopping early may lead to incomplete treatment and antibiotic resistance. Your doctor will determine when to stop based on your clinical response and culture results.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance, superinfections (such as oral thrush or C. difficile colitis), and rarely, blood dyscrasias or liver enzyme elevations. Regular monitoring of blood counts, liver and kidney function is advised during prolonged therapy. Discontinue if any serious adverse effect occurs.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For less severe infections, oral antibiotics may be used instead of IV therapy.
Evidence: Well-establishedOnce culture results are available, therapy may be narrowed to a more targeted antibiotic.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you are scheduled to receive a live vaccine, inform your doctor, as antibiotics may affect the immune response. Generally, antibiotics do not contraindicate vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light and moisture
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
This medicine is administered in a healthcare setting, so travel advice is limited. If you are traveling after treatment, carry a copy of your prescription and medical records. Store any remaining vials as directed, and declare them at customs if required. Consult your doctor before traveling if you need to continue treatment.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24-48 hours, but it is important to complete the full course as prescribed.
A: No, this medicine must be given by a healthcare professional in a hospital or clinic setting.
A: It is classified as Pregnancy Category B. Use only if clearly needed and prescribed by your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for camotri s 500mg/250mg injection
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Saftrax S 500mg/250mg InjectionSA Remedies ₹51.56 35.6% CHEAPER
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ciaxone s 500mg/250mg injectionAstam Health Care Pvt Ltd ₹54.00 32.5% CHEAPER
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wycef s 500mg/250mg injectionYacca Pharmaceuticals Pvt Ltd ₹55.22 31% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections like the flu.
Fact: This medicine is an antibiotic and is only effective against bacterial infections. It does not treat viral infections. - Myth: You can stop this medicine as soon as you feel better.
Fact: You must complete the full course as prescribed by your doctor to prevent recurrence and resistance. - Myth: This medicine is safe to self-administer at home.
Fact: This medicine must be given by a healthcare professional intravenously. It is not for self-administration.
🔄 Alternative Options
Generic Alternatives
- Ceftriaxone + Sulbactam injection (generic)
Brand Alternatives
- Monocef-SB
- Intacef-SB
- Oframax-SB