Calcium Pantothenate (12.5mg) + Methylcobalamin (500mcg) + Niacinamide (50mg) + Vitamin C (100mg) + Vitamin E (25mg) (Medical Monograph)

Overview

A fixed-dose combination of essential water-soluble and fat-soluble vitamins, primarily indicated for the prevention and treatment of B-complex and antioxidant vitamin deficiencies. It is widely used in the Indian context for managing nutritional deficiencies associated with poor diet, malabsorption, chronic alcoholism, and increased metabolic demands. The combination supports energy metabolism, red blood cell formation, neurological function, and provides antioxidant protection.

Uses

  • Nutritional supplementation in vitamin B-complex and antioxidant deficiencies
  • Supportive therapy in peripheral neuropathies (diabetic, alcoholic, nutritional)
  • Management of conditions with increased vitamin requirements: convalescence, chronic illness, post-surgical recovery
  • Adjunct in megaloblastic anemia due to Vitamin B12 deficiency

Side Effects

  • Mild gastrointestinal discomfort (nausea, heartburn)
  • Headache
  • Flushing (rare with niacinamide compared to nicotinic acid)

Detailed Pharmacology

The combination acts synergistically. Calcium Pantothenate (B5) is a precursor to coenzyme A, crucial for fatty acid metabolism. Methylcobalamin (B12) acts as a cofactor for methionine synthase (homocysteine metabolism) and methylmalonyl-CoA mutase (myelin synthesis). Niacinamide (B3) is a precursor to NAD/NADP, coenzymes for redox reactions. Vitamin C is a potent antioxidant and cofactor for collagen synthesis. Vitamin E (alpha-tocopherol) is a lipid-soluble antioxidant protecting cell membranes from peroxidation.

Available Brands in India

BrandManufacturerPrice
Nurokind-Gold Mankind Pharma Ltd. ₹120 - ₹180 for 15 tablets strip
Nervijen Plus Jenburkt Pharmaceuticals Ltd. ₹100 - ₹150 for 10 tablets strip
Nodosis Gold Eris Lifesciences Ltd. ₹130 - ₹190 for 15 tablets strip
Nurodex-G Dexter Laboratories ₹90 - ₹140 for 10 tablets strip
Mecobal-Gold Sun Pharmaceutical Industries Ltd. ₹110 - ₹170 for 15 tablets strip