Bestor FN 10 Tablet: Comprehensive Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe muscle pain, weakness, or dark urine
- Yellowing of skin or eyes (jaundice)
- Severe abdominal pain radiating to the back
- Signs of allergic reaction such as rash, itching, swelling of face or throat, difficulty breathing
- Decreased urine output or swelling in legs
- Unusual bleeding or bruising
- Persistent nausea, vomiting, or loss of appetite
If experiencing severe symptoms, call emergency services immediately.
What is brosuv f 145 tablet used for?
This medicine is a combination of fenofibrate and rosuvastatin used to treat mixed dyslipidemia. It lowers triglycerides, LDL cholesterol, and total cholesterol while raising HDL cholesterol. It is taken orally once daily under medical supervision.
- Generic Name: Fenofibrate + Rosuvastatin
- Manufacturer: Brilliant Lifesciences Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 brosuv f 145 tablet के बारे में (Hindi Summary)
उपयोग: यह दवा फेनोफिब्रेट और रोसुवास्टेटिन का संयोजन है, जिसका उपयोग मिश्रित डिस्लिपिडेमिया के इलाज के लिए किया जाता है। यह ट्राइग्लिसराइड और एलडीएल कोलेस्ट्रॉल को कम करने में मदद करती है और एचडीएल कोलेस्ट्रॉल को बढ़ाती है। यह हृदय रोग के जोखिम को कम करने में सहायक है। इसका सेवन डॉक्टर के परामर्श से ही करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, मतली, पेट दर्द, कब्ज और मांसपेशियों में दर्द शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें लीवर की समस्या, मांसपेशियों का टूटना (रैब्डोमायोलिसिस), और अग्नाशयशोथ शामिल हो सकते हैं। यदि आपको असामान्य मांसपेशी दर्द, कमजोरी, या गहरे रंग का मूत्र दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे भोजन के साथ या बिना भोजन के ले सकते हैं। शराब का सेवन न करें क्योंकि इससे लीवर और मांसपेशियों को नुकसान हो सकता है। नियमित रूप से लीवर, किडनी और लिपिड प्रोफाइल की जांच कराएं। गर्भवती या स्तनपान कराने वाली महिलाएं इस दवा का सेवन न करें। किसी भी असामान्य लक्षण के लिए तुरंत डॉक्टर से मिलें।
💊 brosuv f 145 tablet Uses & Benefits
- [{"condition":"Mixed dyslipidemia","description":"This medicine is used to treat mixed dyslipidemia characterized by elevated LDL cholesterol, elevated triglycerides, and low HDL cholesterol.
- It combines the triglyceride-lowering effect of fenofibrate with the LDL-lowering effect of rosuvastatin.","evidence":"Well-established"},{"condition":"Hypertriglyceridemia with elevated LDL","description":"It is prescribed for patients with severe hypertriglyceridemia who also have high LDL cholesterol, especially when monotherapy with a statin or fibrate is insufficient.","evidence":"Well-established"},{"condition":"Atherosclerotic cardiovascular disease risk reduction","description":"In patients with multiple lipid abnormalities, this combination may help reduce the risk of cardiovascular events by improving the overall lipid profile.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Nonalcoholic fatty liver disease (NAFLD)","description":"Fenofibrate and statins have been studied for potential benefit in NAFLD, but this combination is not approved for this indication.","evidence":"Limited"},{"condition":"Diabetic dyslipidemia","description":"Sometimes used off-label in patients with type 2 diabetes and mixed dyslipidemia, though guidelines recommend statins first.","evidence":"Limited"}]
Primary treatment for: Mixed dyslipidemia
Also treats: Hypertriglyceridemia, Hypercholesterolemia, Atherosclerotic cardiovascular disease, Type 2 diabetes with dyslipidemia
📋 Drug Information
| Generic Name(s) | Fenofibrate + Rosuvastatin |
| Brand Name | Arvast F 10 Tablet |
| Manufacturer | Brilliant Lifesciences Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Lipid-lowering agent (Fibrate + Statin) |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep the tablets in their original container, tightly closed. Protect from moisture, heat, and direct sunlight. Do not refrigerate unless specified by the manufacturer. Keep out of reach of children and pets. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture. Refer to the expiry date printed on the packaging. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary lipid-modifying actions. Fenofibrate activates peroxisome proliferator-activated receptor alpha (PPAR-alpha), which increases the expression of lipoprotein lipase and reduces apolipoprotein C-III, leading to enhanced breakdown of triglycerides and increased HDL cholesterol. Rosuvastatin selectively inhibits HMG-CoA reductase, the rate-limiting enzyme in hepatic cholesterol synthesis, which upregulates LDL receptors and increases clearance of LDL cholesterol from the blood. Together, they provide broad-spectrum lipid control.
Mechanism Steps
💡 How to Take brosuv f 145 tablet
Strength: Each tablet contains fenofibrate 145 mg and rosuvastatin 10 mg. It is an immediate-release oral tablet.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once daily. The dose may be adjusted by your doctor based on your lipid levels, kidney function, and response to therapy. It can be taken with or without food, but taking it with food may improve absorption of fenofibrate and reduce stomach upset. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not change the dose without consulting your doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the effects of this medicine, particularly muscle and kidney-related side effects. Dose selection should be cautious, and renal function should be monitored regularly. No specific dose adjustment is established from the available information, but individualized dosing by a clinician is essential. |
| Renal Impairment | This medicine is contraindicated in patients with severe renal impairment (eGFR <30 mL/min/1.73 m2). In patients with mild to moderate renal impairment, dose adjustments may be necessary. Rosuvastatin dose should not exceed 10 mg in patients with severe renal impairment. Fenofibrate dose may need reduction. Consult your doctor for individualized dosing. |
| Hepatic Impairment | This medicine is contraindicated in patients with active liver disease or unexplained persistent elevations of serum transaminases. In patients with mild to moderate hepatic impairment, no specific dose adjustment is established, but caution is advised. Regular monitoring of liver function is essential. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose of this medicine is one tablet (fenofibrate 145 mg + rosuvastatin 10 mg) once daily. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of brosuv f 145 tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Cyclosporine | Major | |
| Gemfibrozil | Major | |
| Protease inhibitors | Major | |
| Colchicine | Moderate | |
| Fusidic acid | Moderate | |
| Antacids | Moderate | |
| Oral contraceptives | Minor | |
| Digoxin | Minor | |
| Alcohol | Moderate |
🚨 Major Interactions
- Warfarin
- Cyclosporine
- Gemfibrozil
- Protease inhibitors
⚡ Moderate Interactions
- Colchicine
- Fusidic acid
- Antacids (aluminum/magnesium hydroxide)
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol can increase the risk of liver damage, especially with rosuvastatin, and may worsen muscle-related side effects. It can also increase triglyceride levels, counteracting the beneficial effects of fenofibrate.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active liver disease or unexplained persistent elevations of serum transaminases","Severe renal impairment (eGFR
⚠️ Warnings & Precautions
["Muscle effects: This medicine can cause myopathy and rhabdomyolysis. Patients should be advised to report unexplained muscle pain, tenderness, or weakness, especially if accompanied by fever or malaise.","Liver effects: Liver enzyme elevations have been reported. Liver function should be monitored before and during therapy.","Renal effects: Rosuvastatin may cause acute kidney injury. Renal function should be monitored.","Gallstones: Fenofibrate may increase cholesterol excretion into bile, leading to gallstones. Patients with a history of gallbladder disease should be monitored.","Pancreatitis: Rare cases have been reported. Patients with severe abdominal pain should be evaluated.","Diabetes: Statins may increase blood glucose levels. Diabetic patients should monitor glucose control.","Cognitive effects: Rare reports of memory loss and confusion with statins. These are generally reversible upon discontinuation.","Immune-mediated necrotizing myopathy: Rare but serious. Consider if proximal muscle weakness and elevated CK persist despite discontinuation."]
🤱 Lactation Safety
This medicine is contraindicated during breastfeeding. It is not known whether fenofibrate or rosuvastatin are excreted in human milk, but potential serious adverse reactions in nursing infants are possible. A decision should be made to discontinue nursing or the medicine, taking into account the importance of the drug to the mother.
💊 Overdose Management
There is no specific antidote for overdose with this medicine. In case of suspected overdose, treatment should be symptomatic and supportive. Monitor liver and kidney function, and creatine kinase levels. Hemodialysis is not expected to significantly enhance clearance of fenofibrate or rosuvastatin. Patients should seek immediate medical attention if they suspect an overdose.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, usually once daily with or without food. Swallow the tablet whole; do not crush, chew, or split it. Maintain a strict schedule and do not skip doses. Avoid alcohol consumption as it can increase the risk of liver damage and muscle problems. Inform your doctor about all other medications, especially blood thinners, other cholesterol-lowering drugs, and diabetes medicines. Do not start any new medicine without consulting your doctor. Regular monitoring of liver enzymes, kidney function, and lipid levels is mandatory. Report any muscle pain, weakness, dark urine, or yellowing of eyes or skin immediately. If you are pregnant, planning pregnancy, or breastfeeding, do not take this medicine. Keep this medicine out of reach of children. Store at room temperature away from moisture and heat. Do not use after the expiry date.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to muscle and kidney side effects. Renal function should be monitored regularly, and dose adjustments may be necessary. Falls and muscle weakness should be evaluated promptly. The benefits of therapy should be weighed against the risks in this population.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated during pregnancy and in women planning to become pregnant. If you are planning pregnancy, consult your doctor to switch to a safer alternative. Use effective contraception while taking this medicine. If you become pregnant while taking this medicine, stop it immediately and contact your doctor.
🏥 Post-Surgery Considerations
This medicine may increase the risk of bleeding and muscle complications after surgery. Inform your surgeon and anesthesiologist that you are taking this medicine. It may need to be temporarily stopped before surgery, especially if you are also on blood thinners. Follow your doctor's instructions regarding when to resume.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine, especially if you are also on blood thinners. There is no specific contraindication for dental procedures, but your dentist may take precautions to minimize bleeding risk. Maintain good oral hygiene to prevent infections.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause muscle pain or weakness in some patients. If you experience muscle symptoms, avoid strenuous exercise and consult your doctor. Regular moderate exercise is generally safe and beneficial, but listen to your body and do not push through severe muscle pain.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue in some patients. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue your normal work routine, but report any unusual symptoms to your doctor. Take the medicine at the same time each day to minimize disruption.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience serious side effects such as severe muscle pain, dark urine, yellowing of eyes or skin, or severe abdominal pain, seek immediate medical attention and your doctor may advise stopping the medicine. Routine discontinuation should be based on your lipid levels and cardiovascular risk assessment.
📅 Long-Term Use Effects
Long-term use of this medicine requires regular monitoring of liver enzymes, kidney function, and lipid profile. It may increase the risk of gallstones, muscle toxicity, and liver injury. Some patients may experience a slight increase in blood glucose levels. The benefits of reducing cardiovascular risk generally outweigh the risks when used appropriately. Regular follow-up with your doctor is essential to adjust the dose and detect any adverse effects early.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Lifestyle modifications are the foundation of managing dyslipidemia and can complement or reduce the need for medication.
Evidence: Well-establishedStatins alone, fibrates alone, or other combinations may be used depending on the lipid profile.
Evidence: Well-establishedOmega-3 fatty acids, red yeast rice, and plant sterols may have modest lipid-lowering effects.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, always inform your healthcare provider about all medicines you are taking before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. Store at room temperature and protect from moisture. If crossing time zones, continue taking your dose at the same local time as usual, but consult your doctor if you are unsure. Check customs regulations for carrying prescription medicines to your destination. Always carry enough supply for the entire trip and a few extra days in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within days, but maximum lipid-lowering effects are usually seen after 2 to 4 weeks of consistent use.
A: No, you should not stop this medicine without consulting your doctor. Stopping suddenly can cause your lipid levels to rise again.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, this medicine is contraindicated during pregnancy. It may harm the fetus. Use effective contraception while taking this medicine.
A: You should not take other cholesterol-lowering medicines without consulting your doctor, as it may increase the risk of side effects.
🤔 Common Patient Concerns
🔄 Substitutes for brosuv f 145 tablet
View AllAlternative brands with exact same active ingredient:
-
rosu f 145mg/10mg tabletDavaindia Generic Pharmacy ₹31.00 69.4% CHEAPER
-
lipira f 145 mg/10 mg tabletEmcure Pharmaceuticals Ltd ₹87.09 14% CHEAPER
-
Rolmo F 145mg/10mg TabletAblus Pharma ₹93.75 7.4% CHEAPER
-
Roslong F 145mg/10mg TabletSunmarker Pharma ₹98.44 2.8% CHEAPER
-
rosimit f 145mg/10mg tabletMitoch Pharma Pvt Ltd ₹104.00 2.7% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken without a doctor's prescription.
Fact: This medicine is a prescription drug and should only be taken under medical supervision. - Myth: This medicine can replace a healthy diet and exercise.
Fact: This medicine is an adjunct to diet and exercise, not a replacement. - Myth: Once cholesterol levels are normal, this medicine can be stopped.
Fact: Cholesterol levels may rise again if the medicine is stopped. Consult your doctor before discontinuing. - Myth: This medicine has no side effects.
Fact: Like all medicines, this medicine can cause side effects, though not everyone experiences them.
🔄 Alternative Options
Generic Alternatives
- Fenofibrate + Rosuvastatin generic tablets
Brand Alternatives
- Bestor FN 10 Tablet