Brodnem-S Injection - Uses, Price, Side Effects
What is brodnem-s injection used for?
Brodnem-S Injection is a combination antibiotic containing Meropenem (1000mg) and Sulbactam (500mg). It is used to treat severe bacterial infections such as pneumonia, intra-abdominal infections, and meningitis. Meropenem kills bacteria by inhibiting cell wall synthesis, while Sulbactam prevents bacterial resistance by inhibiting beta-lactamase enzymes.
- Generic Name: Meropenem + Sulbactam
- Manufacturer: Nurtureplus Biotech Private Limited
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ brodnem-s injection Uses & Benefits
Complicated intra-abdominal infections, complicated skin and skin structure infections, community-acquired pneumonia, hospital-acquired pneumonia, meningitis, septicemia.
Off-label uses: Febrile neutropenia, cystic fibrosis exacerbations, neonatal sepsis.
๐ Drug Information
| Generic Name(s) | Meropenem + Sulbactam |
| Brand Name | Almero-S 1.5gm Injection |
| Manufacturer | Nurtureplus Biotech Private Limited |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Carbapenem antibiotic + Beta-lactamase inhibitor |
| Route of Administration | Intravenous (IV) |
| Storage | Store at 20-25ยฐC; reconstituted solution stable for 1 hour at room temperature or 4 hours under refrigeration. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Meropenem inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs); Sulbactam inhibits beta-lactamases, preventing degradation of meropenem.
Mechanism Steps
๐ก How to Take brodnem-s injection
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of brodnem-s injection
โ Common Side Effects
- Diarrhea
- Nausea
- Vomiting
- Headache
- Rash
- Phlebitis at injection site
๐จ Serious Side Effects
- Anaphylaxis
- Stevens-Johnson syndrome
- Seizures
- Pseudomembranous colitis
- Bone marrow suppression
โ ๏ธ Rare Side Effects
- Interstitial nephritis
- Hepatitis
- Agranulocytosis
- Thrombocytopenia
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Probenecid | Moderate | Reduced excretion of meropenem |
| Valproic Acid | Major | Decreased valproic acid levels |
๐จ Major Interactions
- Valproic acid
- Probenecid
โก Moderate Interactions
- Warfarin
- Methotrexate
- Oral contraceptives
โน๏ธ Minor Interactions
- Live bacterial vaccines
๐ฝ๏ธ Food Interactions
None (IV administration)
๐ท Alcohol Interaction
No known interaction
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to meropenem, sulbactam, or other beta-lactams; anaphylactic reactions to penicillins.
๐ Monitoring Parameters
Renal function, hepatic function, CBC, signs of hypersensitivity, superinfection.
๐คฑ Lactation Safety
Caution; excreted in breast milk in low amounts.
๐ Overdose Management
Supportive care; hemodialysis may enhance elimination.
โฐ Missed Dose
Administer as soon as remembered; do not double dose.