Brimofinet 5 mg/1.5 mg Eye Drop - Uses, Price, Side Effects
What is brimofinet 5 mg/1.5 mg eye drop used for?
Brimofinet 5 mg/1.5 mg Eye Drop is a combination of Timolol (a beta-blocker) and Brimonidine (an alpha-2 agonist) used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension. It works by reducing the production of aqueous humor and increasing its outflow, thereby protecting the optic nerve from damage.
- Generic Name: Timolol + Brimonidine
- Manufacturer: Calix Health Care
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ brimofinet 5 mg/1.5 mg eye drop Uses & Benefits
Reduction of intraocular pressure in open-angle glaucoma or ocular hypertension
Off-label uses: None commonly reported
๐ Drug Information
| Generic Name(s) | Timolol + Brimonidine |
| Brand Name | Abpress Eye Drop |
| Manufacturer | Calix Health Care |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | OPHTHAL |
| Action Class | Beta-blocker + Alpha-2 adrenergic agonist |
| Route of Administration | Ophthalmic (topical) |
| Storage | Store at 15-30ยฐC, protect from light, keep tightly closed |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Timolol reduces aqueous humor production by blocking beta-adrenergic receptors; Brimonidine reduces aqueous humor production and increases uveoscleral outflow by stimulating alpha-2 adrenergic receptors
Mechanism Steps
๐ก How to Take brimofinet 5 mg/1.5 mg eye drop
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of brimofinet 5 mg/1.5 mg eye drop
โ Common Side Effects
- Ocular burning/stinging
- Blurred vision
- Dry eye
- Eye redness
- Headache
- Drowsiness
๐จ Serious Side Effects
- Bradycardia
- Heart block
- Bronchospasm
- Hypotension
- Syncope
- Allergic reaction
โ ๏ธ Rare Side Effects
- Depression
- Insomnia
- Corneal edema
- Uveitis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Beta-blockers (oral) | Moderate | Additive systemic beta-blockade |
| MAO inhibitors | Major | Hypertensive crisis |
| Digoxin | Moderate | Bradycardia |
๐จ Major Interactions
- Beta-blockers (systemic)
- Calcium channel blockers
- Digoxin
- Clonidine
- MAO inhibitors
โก Moderate Interactions
- Antihypertensives
- Antidiabetic agents
- Tricyclic antidepressants
โน๏ธ Minor Interactions
- Corticosteroids
- NSAIDs
๐ฝ๏ธ Food Interactions
No significant food interactions
๐ท Alcohol Interaction
May enhance hypotensive effect
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Bronchial asthma, COPD, sinus bradycardia, second/third-degree AV block, cardiogenic shock, hypersensitivity to components
๐ Monitoring Parameters
Intraocular pressure, heart rate, blood pressure, signs of ocular irritation
๐คฑ Lactation Safety
Not recommended; may be excreted in breast milk
๐ Overdose Management
Supportive care; monitor heart rate and blood pressure; symptomatic treatment
โฐ Missed Dose
Apply as soon as remembered; if near next dose, skip missed dose