bizen 1000mg tablet - Uses, Price, Side Effects & Substitutes
What is bizen 1000mg tablet used for?
Antizide (Pyrazinamide) is used to treat ANTI INFECTIVES. It contains Pyrazinamide (1000mg), which Converted to pyrazinoic acid, which lowers pH and inhibits fatty acid synthase (. Always consult your doctor before use. Take as prescribed.
- Generic Name: Pyrazinamide
- Manufacturer: Brilliant Lifesciences Pvt Ltd
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ bizen 1000mg tablet Uses & Benefits
First-line treatment of tuberculosis (in combination with other antitubercular drugs).
Off-label uses: None well-established.
๐ Drug Information
| Generic Name(s) | Pyrazinamide |
| Brand Name | Antizide |
| Manufacturer | Brilliant Lifesciences Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Mycobacterial fatty acid synthase |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF) in a dry place. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Converted to pyrazinoic acid, which lowers pH and inhibits fatty acid synthase (FAS I) in Mycobacterium tuberculosis.
Mechanism Steps
๐ก How to Take bizen 1000mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of bizen 1000mg tablet
โ Common Side Effects
- Hepatotoxicity
- Hyperuricemia
- Arthralgia
- Nausea
- Vomiting
๐จ Serious Side Effects
- Severe hepatitis
- Acute gouty arthritis
- Rash
- Fever
โ ๏ธ Rare Side Effects
- Photosensitivity
- Thrombocytopenia
- Sideroblastic anemia
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Rifampin | Major | Increased hepatotoxicity risk |
| Isoniazid | Major | Increased hepatotoxicity risk |
| Ethambutol | Major | Increased hepatotoxicity risk |
| Oral contraceptives | Moderate | Reduced contraceptive efficacy |
| Antacids | Moderate | Decreased absorption of pyrazinamide |
| Corticosteroids | Moderate | Increased hepatotoxicity risk |
| Probenecid | Minor | Decreased renal excretion of pyrazinamide |
| Sulfinpyrazone | Minor | Decreased renal excretion of pyrazinamide |
๐จ Major Interactions
- Rifampin
- Isoniazid
- Ethambutol
โก Moderate Interactions
- Oral contraceptives
- Antacids
- Corticosteroids
โน๏ธ Minor Interactions
- Probenecid
- Sulfinpyrazone
๐ฝ๏ธ Food Interactions
No significant food interactions.
๐ท Alcohol Interaction
May increase hepatotoxicity risk; avoid alcohol.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Severe hepatic damage, acute gout, hypersensitivity to pyrazinamide.
๐ Monitoring Parameters
Liver function tests (AST, ALT), serum uric acid, renal function.
๐คฑ Lactation Safety
Excreted in breast milk; use with caution.
๐ Overdose Management
Induce emesis or gastric lavage; supportive care; monitor liver function.
โฐ Missed Dose
Take as soon as remembered unless near next dose; do not double dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for bizen 1000mg tablet
View AllAlternative brands with exact same active ingredient (Pyrazinamide (1000mg)):
-
pza ciba 1000mg tabletNovartis India Ltd โน10.86 87.2% CHEAPER
-
macrozide 1000 tabletMacleods Pharmaceuticals Pvt Ltd โน59.53 30% CHEAPER
-
actizid 1000mg tabletOverseas Healthcare Pvt Ltd โน63.09 25.8% CHEAPER
-
kemide 1000mg tabletAnikem Laboratories โน79.50 6.5% CHEAPER
-
mzide 1000mg tabletMarc Laboratories Pvt Ltd โน80.60 5.2% CHEAPER
-
zin 1000mg tabletRadicura Pharma pvt ltd โน81.00 4.7% CHEAPER
-
pyzina 1000 tabletLupin Ltd โน109.75 29.1% COSTLIER
-
p zide 1000 tabletCadila Pharmaceuticals Ltd โน109.91 29.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.