Acuzone S 1000mg/500mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of face, lips, or throat
- Severe or bloody diarrhea
- Rash with blistering or peeling skin
- Yellowing of eyes or skin
- Decreased urine output
- Unusual bleeding or bruising
- High fever with chills not improving
If experiencing severe symptoms, call emergency services immediately.
What is biowar cs 1000 mg/500 mg injection used for?
This medicine is a combination antibiotic injection containing cefoperazone and sulbactam. It is used to treat serious bacterial infections in hospitals. It works by killing bacteria and is given intravenously by a healthcare professional.
- Generic Name: Cefoperazone + Sulbactam
- Manufacturer: Bio Warriors Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 biowar cs 1000 mg/500 mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा एक संयोजन एंटीबायोटिक इंजेक्शन है जिसमें सेफोपेराज़ोन और सल्बैक्टम शामिल हैं। इसका उपयोग अस्पताल में गंभीर बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है, जैसे निमोनिया, मूत्र पथ के संक्रमण, पेट के अंदर के संक्रमण, त्वचा के संक्रमण और रक्त के संक्रमण। यह दवा बैक्टीरिया को मारकर काम करती है और इसे डॉक्टर या नर्स द्वारा नस के माध्यम से दिया जाता है। यह दवा केवल बैक्टीरियल संक्रमणों के लिए है, वायरल संक्रमण जैसे सर्दी-जुकाम के लिए नहीं।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में दस्त, जी मिचलाना, उल्टी, त्वचा पर चकत्ते और इंजेक्शन लगाने की जगह पर दर्द या सूजन शामिल हैं। गंभीर लेकिन दुर्लभ दुष्प्रभावों में तेज एलर्जी, गंभीर दस्त, रक्त विकार और लीवर की समस्या हो सकती है। यदि आपको सांस लेने में कठिनाई, चेहरे या गले में सूजन, या गंभीर दस्त हो तो तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल डॉक्टर या नर्स द्वारा अस्पताल में दी जानी चाहिए। इससे पहले कि आपको यह दवा दी जाए, अपने डॉक्टर को अपनी सभी एलर्जी, खासकर पेनिसिलिन या सेफलोस्पोरिन से एलर्जी के बारे में बताएं। यदि आपको किडनी या लीवर की बीमारी है, खून से जुड़ी समस्या है, या आप गर्भवती या स्तनपान करा रही हैं, तो डॉक्टर को बताएं। इलाज के दौरान शराब न पिएं। पूरा कोर्स पूरा करें, भले ही आप बेहतर महसूस करें।
💊 biowar cs 1000 mg/500 mg injection Uses & Benefits
[{"condition":"Hospital-acquired pneumonia","description":"Used to treat pneumonia acquired during hospital stay, especially when resistant bacteria are suspected.","evidence":"Well-established"},{"condition":"Complicated urinary tract infections","description":"Effective against urinary tract infections that have spread to the kidneys or are caused by resistant organisms.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Treats infections in the abdominal cavity such as peritonitis and abscesses.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Used for severe skin infections including cellulitis and infected wounds.","evidence":"Well-established"},{"condition":"Septicemia","description":"Used in bloodstream infections caused by susceptible Gram-negative and Gram-positive bacteria.","evidence":"Well-established"},{"condition":"Gynecological infections","description":"Treats pelvic inflammatory disease and other serious infections of the female reproductive organs.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Febrile neutropenia","description":"Sometimes used as empirical therapy in cancer patients with low white blood cell counts and fever.","evidence":"Limited"},{"condition":"Meningitis","description":"May be used off-label for bacterial meningitis when other options are not suitable, but not first-line.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Pneumonia, Urinary tract infections, Intra-abdominal infections, Skin infections, Septicemia
📋 Drug Information
| Generic Name(s) | Cefoperazone + Sulbactam |
| Brand Name | Acuzone S 1000mg/500mg Injection |
| Manufacturer | Bio Warriors Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporin + Beta-lactamase inhibitor |
| Route of Administration | Intravenous (IV) infusion or injection |
| Storage | Store below 25°C (77°F) in a dry place, protected from light. Reconstituted solutions should be used immediately or stored as directed by the manufacturer. Do not freeze. |
| Shelf Life | 24 months from the date of manufacture, unless otherwise specified on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Cefoperazone inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to bacterial lysis. Sulbactam irreversibly inhibits certain beta-lactamase enzymes, protecting cefoperazone from degradation and extending its spectrum against beta-lactamase-producing bacteria.
Mechanism Steps
💡 How to Take biowar cs 1000 mg/500 mg injection
Strength: Injection: Cefoperazone 1000 mg + Sulbactam 500 mg per vial.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 1 g to 2 g of cefoperazone with 0.5 g to 1 g of sulbactam administered intravenously every 12 hours. For severe infections, the dose may be increased to 2 g cefoperazone with 1 g sulbactam every 12 hours. The maximum daily dose is 4 g cefoperazone with 2 g sulbactam. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may have reduced renal function; dose should be adjusted based on creatinine clearance. Use with caution and monitor renal function. |
| Renal Impairment | In patients with renal impairment (creatinine clearance <30 mL/min), dose adjustment is recommended. The dose may need to be reduced or the dosing interval extended. Monitor renal function closely. |
| Hepatic Impairment | In patients with hepatic impairment, dose adjustment may be necessary. Monitor liver function tests. Cefoperazone is primarily excreted in bile, so hepatic impairment can affect its elimination. |
| Maximum Daily Dose | Maximum daily dose: 4 g cefoperazone + 2 g sulbactam. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of biowar cs 1000 mg/500 mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Gentamicin | Major | |
| Furosemide | Moderate | |
| Probenecid | Moderate | |
| Alcohol | Major | |
| Oral contraceptives | Minor |
🚨 Major Interactions
- Warfarin
- Aminoglycosides (e.g., gentamicin)
- Alcohol
⚡ Moderate Interactions
- Loop diuretics (e.g., furosemide)
- Probenecid
🍷 Alcohol Interaction
Avoid alcohol during treatment with this medicine as it may cause a disulfiram-like reaction characterized by flushing, nausea, vomiting, and headache. Alcohol may also worsen liver-related side effects.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe allergy to penicillins, cephalosporins, or beta-lactam antibiotics","Previous anaphylactic reaction to beta-lactams","Use in patients with known sulbactam hypersensitivity"]
⚠️ Warnings & Precautions
["Serious and occasionally fatal hypersensitivity reactions can occur. Before therapy, inquire about previous hypersensitivity to penicillins, cephalosporins, or other allergens.","Clostridioides difficile-associated diarrhea may occur. If diarrhea develops, evaluate for this condition.","Use with caution in patients with renal impairment; dose adjustment may be needed.","Use with caution in patients with hepatic impairment; monitor liver function.","Prolonged use may result in overgrowth of non-susceptible organisms.","May cause false-positive results in certain urine glucose tests.","Avoid alcohol during treatment due to disulfiram-like reactions."]
🤱 Lactation Safety
Cefoperazone and sulbactam are excreted in human milk in small amounts. Consult your doctor before breastfeeding while on this medicine. The benefits may outweigh risks in serious infections.
💊 Overdose Management
Overdose with this medicine is unlikely due to its intravenous administration by healthcare professionals. In case of accidental overdose, treatment should be symptomatic and supportive. Cefoperazone and sulbactam can be removed by hemodialysis. Contact a poison control center or emergency department immediately if overdose is suspected.
⏰ Missed Dose
This medicine is administered by healthcare professionals in a clinical setting. If you miss a scheduled dose, contact your healthcare provider as soon as possible. Do not attempt to self-administer a double dose.
Additional Safety Advice
This medicine must be administered only by a healthcare professional in a clinical setting. Inform your doctor about any allergies to antibiotics, especially penicillins or cephalosporins, before receiving this medicine. Tell your doctor if you have kidney or liver disease, bleeding disorders, or if you are pregnant or breastfeeding. Do not self-administer this injection. Complete the full course as prescribed, even if you feel better, to prevent resistance. Avoid alcohol during treatment as it may worsen side effects. Report any severe diarrhea, rash, or difficulty breathing immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function and may require dose adjustment. They are also at higher risk of side effects such as diarrhea and allergic reactions. Close monitoring is recommended.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before starting this medicine. It is generally used during pregnancy only if clearly needed. Discuss the risks and benefits with your healthcare provider.
🏥 Post-Surgery Considerations
This medicine may be used to treat or prevent infections after surgery. It is administered intravenously in a hospital setting. Follow your surgeon's instructions regarding wound care and activity restrictions.
🦷 Dental Procedures
Inform your dentist if you are on this medicine. It may be used to treat dental infections that have spread, but it is not routinely used for dental prophylaxis. Your dentist will coordinate with your doctor if needed.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While on this medicine, you may feel tired or weak. Avoid strenuous exercise until you have recovered. Light activity such as walking is generally fine if you feel up to it. Consult your doctor before resuming intense workouts.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital or clinic, so you may need to take time off work for treatment. You may feel fatigued during recovery. Driving is generally not recommended if you feel unwell or dizzy. Discuss with your doctor when you can return to normal activities.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Complete the full course as prescribed, even if you feel better. Stopping early can lead to recurrence of infection and antibiotic resistance. If you experience severe side effects, contact your doctor immediately; they will decide whether to stop or change the treatment.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance, superinfections, and rarely, blood or liver abnormalities. Prolonged therapy should be guided by clinical response and culture results. Regular monitoring of renal, hepatic, and hematologic parameters is advised.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on culture results, other antibiotics such as ceftriaxone, piperacillin-tazobactam, or carbapenems may be used.
Evidence: Well-establishedRest, hydration, and fever control are important adjuncts to antibiotic therapy.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Antibiotics do not interact with vaccines. However, if you are scheduled for a vaccine, inform your doctor. There is no need to delay vaccination unless you are acutely ill.
📦 Storage Guide
✅ DO
Store below 25°C in a dry place
❌ DON'T
Do not freeze
✅ DO
Keep in original packaging
❌ DON'T
Do not use if solution is discolored or contains particles
✅ DO
Protect from light
❌ DON'T
Do not store in bathroom
✈️ Traveling with This Medicine
This medicine is administered in a healthcare setting, so travel is not typically applicable. If you are traveling after treatment, carry a copy of your prescription and medical records. Store any remaining medication as directed, and ensure you have enough for the duration of your trip. Consult your doctor before traveling if you are still on treatment.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 2-3 days, but it is important to complete the full course as prescribed.
A: No, this medicine must be given by a healthcare professional in a clinical setting.
A: Consult your doctor. It is used only if clearly needed and prescribed.
A: Common side effects include diarrhea, nausea, rash, and injection site pain.
🤔 Common Patient Concerns
🔄 Substitutes for biowar cs 1000 mg/500 mg injection
View AllAlternative brands with exact same active ingredient:
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cfzone 1000mg/500mg injectionAstopic Lifescience ₹32.81 80.8% CHEAPER
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kexone plus 1000 mg/500 mg injectionMedispan Ltd ₹96.85 43.4% CHEAPER
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hb zone sb 1000mg/500mg injectionHealth Biomed Pharma ₹103.13 39.7% CHEAPER
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cefone-sb 1.5gm injectionMakers Laboratories Ltd ₹106.13 37.9% CHEAPER
-
kefzone 1000mg/500mg injectionKestrel Lifesciences ₹109.69 35.9% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections like cold or flu.
Fact: This medicine is an antibiotic and only works against bacterial infections. It is ineffective against viruses. - Myth: You can stop the injection once you feel better.
Fact: You must complete the full course as prescribed to prevent recurrence and resistance, even if symptoms improve. - Myth: This medicine is safe to self-administer at home.
Fact: This medicine must be given by a healthcare professional in a clinical setting due to the risk of serious allergic reactions and need for monitoring.
🔄 Alternative Options
Generic Alternatives
- Cefoperazone + Sulbactam injection (generic)
Brand Alternatives
- Not established from the available information.