Biotic-O Ear Drop - Uses, Price, Side Effects
What is biotic-o ear drop used for?
Biotic-O Ear Drop is a combination medicine used to treat ear infections caused by bacteria and fungi. It contains Gentamicin, an antibiotic that stops bacterial growth, and Clotrimazole, an antifungal that kills fungi. It works directly in the ear canal to relieve infection symptoms like pain, itching, and discharge.
- Generic Name: Gentamicin + Clotrimazole
- Manufacturer: Bio-Zenesis Healthcare
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ biotic-o ear drop Uses & Benefits
Treatment of otitis externa and other superficial ear infections caused by susceptible bacteria and fungi.
Off-label uses: Prophylaxis in ear surgery, Treatment of fungal otomycosis alone
๐ Drug Information
| Generic Name(s) | Gentamicin + Clotrimazole |
| Brand Name | Auricle Ear Drop |
| Manufacturer | Bio-Zenesis Healthcare |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | OTOLOGICALS |
| Action Class | Antibiotic + Antifungal |
| Route of Administration | Otic (topical). |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Gentamicin: inhibits bacterial protein synthesis by binding to 30S ribosomal subunit; Clotrimazole: inhibits fungal ergosterol synthesis by inhibiting 14ฮฑ-demethylase.
Mechanism Steps
๐ก How to Take biotic-o ear drop
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of biotic-o ear drop
โ Common Side Effects
- Local irritation
- Stinging
- Itching
๐จ Serious Side Effects
- Ototoxicity (rare with topical use)
- Allergic reaction
โ ๏ธ Rare Side Effects
- Superinfection
- Contact dermatitis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Aminoglycosides | Moderate | Increased ototoxicity risk |
| Loop diuretics | Moderate | Increased ototoxicity risk |
| Neuromuscular blocking agents | Major | Enhanced neuromuscular blockade |
๐จ Major Interactions
- Aminoglycosides (systemic)
- Ototoxic drugs (e.g., loop diuretics)
- Nephrotoxic drugs
โก Moderate Interactions
- Warfarin
- CYP3A4 inhibitors/inducers (for clotrimazole)
โน๏ธ Minor Interactions
- Topical corticosteroids
๐ท Alcohol Interaction
No known interaction.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to gentamicin, clotrimazole, or any component; perforated tympanic membrane (relative).
๐ Monitoring Parameters
Clinical response; signs of ototoxicity (if perforated TM); renal function (if prolonged use).
๐คฑ Lactation Safety
Use with caution; minimal systemic absorption unlikely to affect infant.
๐ Overdose Management
Unlikely with topical use; if ingested, supportive care.
โฐ Missed Dose
Apply as soon as remembered; skip if almost time for next dose.