Biotax SB 250 mg/125 mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or wheezing
- Swelling of the face, lips, tongue, or throat
- Severe rash, blistering, or peeling skin
- Severe diarrhea with blood or mucus
- Chest pain or palpitations
- Decreased urine output or swelling in the legs
- Yellowing of the skin or eyes
- Unusual bleeding or bruising
- Seizures or confusion
If experiencing severe symptoms, call emergency services immediately.
What is biotax sb 250 mg/125 mg injection used for?
This medicine is an intravenous antibiotic combination of cefotaxime and sulbactam used to treat moderate to severe bacterial infections. It works by killing bacteria and preventing their resistance. It is given by a healthcare professional in a hospital setting.
- Generic Name: Cefotaxime + Sulbactam
- Manufacturer: Biochem Pharmaceutical Industries
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 biotax sb 250 mg/125 mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा सेफोटैक्साइम और सल्बैक्टम का संयोजन है, जिसे नस के माध्यम से दिया जाता है। यह मध्यम से गंभीर जीवाणु संक्रमणों के इलाज के लिए उपयोग की जाती है, जैसे निमोनिया, मूत्र मार्ग संक्रमण, पेट के अंदर के संक्रमण, त्वचा संक्रमण, और रक्त संक्रमण। यह दवा बैक्टीरिया को मारती है और उनके प्रतिरोध को रोकती है। यह केवल अस्पताल में डॉक्टर या नर्स द्वारा ही दी जानी चाहिए। वायरल संक्रमण जैसे सर्दी-जुकाम के लिए यह दवा प्रभावी नहीं है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन की जगह पर दर्द, लालिमा या सूजन, दस्त, जी मिचलाना, उल्टी, हल्के दाने, और सिरदर्द शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी की प्रतिक्रिया, गंभीर त्वचा प्रतिक्रिया, आंतों का गंभीर संक्रमण, और रक्त विकार हो सकते हैं। यदि आपको सांस लेने में कठिनाई, चेहरे या गले में सूजन, गंभीर दस्त, या त्वचा पर चकत्ते दिखें तो तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल प्रशिक्षित स्वास्थ्य पेशेवर द्वारा अस्पताल में ही दी जानी चाहिए। इससे पहले कि आपको यह दवा दी जाए, अपने डॉक्टर को अपनी सभी एलर्जी, खासकर पेनिसिलिन या सेफलोस्पोरिन से, और गुर्दे या यकृत की समस्याओं के बारे में बताएं। अपनी सभी दवाओं की जानकारी दें। इलाज के दौरान गुर्दे और यकृत की कार्यप्रणाली और रक्त की जांच की निगरानी की जा सकती है। बेहतर महसूस होने पर भी पूरा कोर्स पूरा करें।
💊 biotax sb 250 mg/125 mg injection Uses & Benefits
[{"condition":"Community-acquired pneumonia","description":"Used to treat moderate to severe bacterial pneumonia caused by susceptible organisms, including some beta-lactamase-producing strains.","evidence":"Well-established"},{"condition":"Complicated urinary tract infections","description":"Effective against pyelonephritis and other complicated urinary infections caused by susceptible Gram-negative bacteria.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Used in combination with other antibiotics or alone for intra-abdominal infections such as peritonitis and abscesses caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats cellulitis, wound infections, and abscesses caused by susceptible Gram-positive and Gram-negative bacteria.","evidence":"Well-established"},{"condition":"Bloodstream infections (septicemia)","description":"Used to treat bacteremia caused by susceptible organisms, often as part of a broader treatment plan.","evidence":"Well-established"},{"condition":"Gynecological infections","description":"Effective in treating pelvic inflammatory disease and other gynecological infections caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Meningitis","description":"Cefotaxime is used for bacterial meningitis, and the addition of sulbactam may help against beta-lactamase-producing strains.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Prophylaxis in surgical procedures","description":"Sometimes used off-label for surgical prophylaxis in certain procedures, though other agents are more commonly recommended.","evidence":"Limited"},{"condition":"Febrile neutropenia","description":"May be used off-label as part of empiric therapy in febrile neutropenia, but other regimens are more standard.","evidence":"Limited"}]
Primary treatment for: Bacterial infections caused by susceptible organisms
Also treats: Pneumonia, Urinary tract infections, Intra-abdominal infections, Skin and soft tissue infections, Septicemia, Meningitis, Gynecological infections
📋 Drug Information
| Generic Name(s) | Cefotaxime + Sulbactam |
| Brand Name | Augtax 1000 mg/500 mg Injection |
| Manufacturer | Biochem Pharmaceutical Industries |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporin + Beta-lactamase inhibitor |
| Route of Administration | Intravenous (IV) injection or infusion. It may be given as a slow injection over 3-5 minutes or as an infusion over 20-30 minutes after dilution |
| Storage | Store the unreconstituted powder at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Once reconstituted, the solution should be used immediately or stored as directed by the manufacturer. Do not freeze. Keep out of reach of children. |
| Shelf Life | The shelf life of the unreconstituted powder is typically 24 months from the date of manufacture. Check the expiry date on the packaging. Once reconstituted, use within the time specified by the manufacturer, usually within 1 hour if kept at room temperature. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Cefotaxime, the active antibiotic component, works by binding to specific penicillin-binding proteins inside the bacterial cell wall. This binding blocks the cross-linking of peptidoglycan strands, which is essential for building a strong bacterial cell wall. As a result, the bacterial cell wall weakens, and the bacterium dies due to osmotic pressure. Sulbactam is a beta-lactamase inhibitor that protects cefotaxime from being destroyed by certain bacterial enzymes called beta-lactamases. By irreversibly binding to these enzymes, sulbactam ensures that cefotaxime remains active against bacteria that would otherwise be resistant. This combination extends the spectrum of cefotaxime to include some beta-lactamase-producing strains of Staphylococcus aureus, Escherichia coli, Klebsiella species, and Bacteroides species.
Mechanism Steps
💡 How to Take biotax sb 250 mg/125 mg injection
Strength: This medicine is supplied as a sterile powder for injection containing 250 mg cefotaxime and 125 mg sulbactam per vial. It is reconstituted with a suitable diluent before intravenous administration.
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the type and severity of infection, the patient's age, weight, kidney and liver function, and the susceptibility of the bacteria. Typical adult doses range from 1 gram to 2 grams of cefotaxime equivalent every 6 to 8 hours, but the specific dose for this 250 mg/125 mg formulation will be determined by your doctor. It is given intravenously. Do not self-administer. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information for this specific combination. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may have reduced kidney function, which can increase the levels of this medicine in the body. Dose adjustment may be necessary based on kidney function. Your doctor will determine the appropriate dose. Close monitoring for side effects is advised. |
| Renal Impairment | Dose adjustment is required in patients with kidney impairment. For cefotaxime, the dose or frequency may be reduced when creatinine clearance is below 20 mL/min. Sulbactam also requires adjustment. Your doctor will calculate the appropriate dose based on your kidney function. Regular monitoring of kidney function is recommended. |
| Hepatic Impairment | No specific dose adjustment is typically required for mild to moderate liver impairment. However, in severe liver disease, caution is advised, and monitoring of liver function is recommended. Your doctor will determine if any adjustment is needed. |
| Maximum Daily Dose | The maximum daily dose is determined by your doctor based on the severity of infection and your kidney function. For cefotaxime, the maximum recommended dose is 12 grams per day in severe infections, but this specific formulation's maximum daily dose will be individualized. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of biotax sb 250 mg/125 mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Gentamicin | Major | |
| Furosemide | Major | |
| Warfarin | Major | |
| Probenecid | Moderate | |
| Oral contraceptives | Moderate | |
| Methotrexate | Moderate | |
| Chloramphenicol | Moderate | |
| Antacids | Minor | |
| Iron supplements | Minor | |
| Alcohol | Minor |
🚨 Major Interactions
- Aminoglycosides (e.g., gentamicin, tobramycin)
- Loop diuretics (e.g., furosemide)
- Warfarin
- Probenecid
⚡ Moderate Interactions
- Oral contraceptives
- Methotrexate
- Chloramphenicol
🍷 Alcohol Interaction
Alcohol does not directly interact with this medicine, but drinking alcohol while you have an infection can worsen your condition, dehydrate you, and increase the risk of liver problems. It is best to avoid alcohol until you have fully recovered and your doctor says it is safe.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe allergy to cefotaxime, sulbactam, or any other cephalosporin or beta-lactam antibiotic","Previous anaphylactic reaction to penicillins or cephalosporins","Use in patients with a history of severe beta-lactam-associated immediate hypersensitivity reactions"]
⚠️ Warnings & Precautions
["Before starting this medicine, inform your doctor about all your allergies, especially to antibiotics.","Use with caution in patients with kidney disease; dose adjustment may be needed.","Use with caution in patients with liver disease; monitor liver function.","Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi.","If severe diarrhea occurs, consider Clostridioides difficile infection and manage appropriately.","This medicine may interfere with certain laboratory tests, such as urine glucose tests and Coombs test.","Safety and effectiveness in children have not been fully established for the combination, but cefotaxime is used in children; consult a pediatrician.","Elderly patients may have reduced kidney function and may require dose adjustment.","Do not use this medicine for viral infections; it is ineffective against viruses."]
🤱 Lactation Safety
Cefotaxime and sulbactam are excreted in human breast milk in small amounts. The amount is generally considered too low to cause harm to a nursing infant, but caution is advised. Monitor the infant for diarrhea, thrush, or rash. Consult your doctor before breastfeeding while receiving this medicine.
💊 Overdose Management
Overdose with this medicine is unlikely in a supervised medical setting. If overdose is suspected, it may cause severe gastrointestinal symptoms, seizures, or kidney damage. Treatment is supportive and symptomatic. Cefotaxime and sulbactam can be removed by hemodialysis in cases of severe toxicity. Contact a poison control center or emergency department immediately if overdose is suspected.
⏰ Missed Dose
This medicine is given by a healthcare professional, so missed doses are unlikely. If you miss a scheduled dose, contact your doctor or nurse as soon as possible. Do not attempt to self-administer an extra dose. Your healthcare provider will determine the best course of action.
Additional Safety Advice
This medicine must be given only by a trained healthcare professional in a setting where emergency equipment is available. Before receiving this medicine, tell your doctor about all your allergies, especially to penicillins or cephalosporins, and about any kidney or liver problems. Inform your doctor about all other medicines you take, including blood thinners, water pills, and pain relievers, because interactions can occur. Do not attempt to use this medicine at home or without medical supervision. If you develop a rash, swelling, difficulty breathing, or severe diarrhea, seek medical help immediately. Your doctor may monitor your kidney function, liver function, and blood counts during treatment. Complete the full course as prescribed, even if you feel better, to prevent resistance and relapse.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function, which can lead to higher blood levels of this medicine and an increased risk of side effects. Dose adjustment based on kidney function is often necessary. Close monitoring for kidney function, blood counts, and signs of allergic reactions is recommended. Elderly patients may also be more susceptible to Clostridioides difficile infection.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before starting this medicine. Cefotaxime and sulbactam are generally considered safe in pregnancy when needed, but the decision should be made by your doctor based on the infection and your overall health. Use effective contraception if you are of childbearing age and not planning pregnancy, as antibiotics may reduce the effectiveness of oral contraceptives.
🏥 Post-Surgery Considerations
This medicine may be used after surgery to treat or prevent infections. If you have recently had surgery, inform your surgeon and anesthesiologist about all medicines you are taking. This medicine may interact with other drugs used during surgery. Follow your surgeon's instructions for wound care and monitoring for signs of infection.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine, especially if you are scheduled for a dental procedure. There is no direct interaction with dental anesthetics, but your dentist may need to know about your infection and treatment. Maintain good oral hygiene to prevent dental infections.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While receiving this medicine, you may feel tired or weak. Avoid strenuous exercise until you have fully recovered. Light activities like walking may be beneficial, but consult your doctor before resuming your regular exercise routine. If you experience dizziness or shortness of breath, stop and rest.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital or clinic, so you will likely need to take time off work during treatment. You may experience fatigue, dizziness, or diarrhea, which can affect your ability to work. Avoid driving or operating heavy machinery until you know how the medicine affects you. Discuss with your employer about sick leave and return-to-work plans.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. Your doctor will decide when to stop based on your clinical response and test results. Stopping early can lead to recurrence of infection and antibiotic resistance. If you experience severe side effects, your doctor may switch you to a different antibiotic.
📅 Long-Term Use Effects
Long-term use of this medicine is not common, as it is typically used for short courses to treat acute infections. Prolonged use may increase the risk of antibiotic resistance, fungal overgrowth, and Clostridioides difficile infection. Regular monitoring of kidney and liver function is advised if extended therapy is necessary. When used appropriately for a limited duration, long-term adverse effects are unlikely.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the bacteria and its susceptibility, other antibiotics such as ceftriaxone, cefepime, or piperacillin-tazobactam may be used.
Evidence: Well-establishedRest, hydration, and fever control are important adjuncts to antibiotic therapy.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, if you are due for any vaccinations, inform your doctor. Live vaccines should generally be avoided while you have an active infection and are on antibiotics. Complete your vaccination schedule as advised by your doctor after recovery.
📦 Storage Guide
✅ DO
Store the unreconstituted powder at room temperature (15-30°C).
❌ DON'T
Do not refrigerate or freeze the powder.
✅ DO
Keep the vial in its original carton to protect from light.
❌ DON'T
Do not expose to direct sunlight.
✅ DO
Use the reconstituted solution immediately or within the time specified by the manufacturer.
❌ DON'T
Do not store reconstituted solution for extended periods.
✅ DO
Keep out of reach of children.
❌ DON'T
Do not use if the solution is discolored or contains particles.
✈️ Traveling with This Medicine
This medicine is given in a hospital or clinic setting, so travel is not typically applicable. If you are traveling after treatment, carry a copy of your prescription and medical records. If you need to continue treatment while traveling, arrange for a healthcare professional to administer the injections. Store the medicine in its original packaging and keep it at room temperature, away from direct sunlight. Check with your airline about carrying injectable medicines and carry a doctor's letter. For international travel, ensure you have sufficient supply and documentation.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working quickly after intravenous administration. You may notice improvement in symptoms such as fever and pain within 24 to 48 hours, but it is important to complete the full course as prescribed.
A: No, this medicine must be given by a healthcare professional in a hospital or clinic setting. It is not for self-administration.
A: Since this medicine is given by a healthcare professional, missed doses are unlikely. If you miss a scheduled dose, inform your doctor or nurse immediately. Do not attempt to self-administer an extra dose.
A: No specific food restrictions are required because the medicine is given intravenously. However, maintaining a healthy diet and staying hydrated can help your recovery.
A: It is best to avoid alcohol while you are being treated for an infection. Alcohol can worsen your condition, dehydrate you, and put extra stress on your liver.
A: This medicine is generally considered safe during pregnancy when clearly needed, but you should consult your doctor to weigh the benefits and risks.
A: Signs include rash, itching, swelling of the face or throat, difficulty breathing, and a sudden drop in blood pressure. Seek emergency help immediately if these occur.
🤔 Common Patient Concerns
🔄 Substitutes for biotax sb 250 mg/125 mg injection
View AllAlternative brands with exact same active ingredient:
-
Sultax 250 mg/125 mg InjectionIpca Laboratories Ltd ₹15.90 15.2% CHEAPER
-
avicef s 250mg/125mg injectionAdmac Pharma Ltd ₹17.34 7.5% CHEAPER
-
duotax 250 mg/125 mg injectionAristo Pharmaceuticals Pvt Ltd ₹19.97 6.5% COSTLIER
-
otax s 250 mg/125 mg injectionSwiss Pharma Pvt Ltd ₹20.00 6.7% COSTLIER
-
Flotax S 250mg/125mg InjectionFlora Biotech ₹22.50 20% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections like the flu.
Fact: This medicine is an antibiotic and is only effective against bacterial infections. It does not treat viral infections. - Myth: You can stop taking this medicine as soon as you feel better.
Fact: You must complete the full course as prescribed by your doctor to prevent the infection from returning and to avoid antibiotic resistance. - Myth: This medicine is safe to self-administer at home.
Fact: This medicine is an injectable antibiotic that must be given by a healthcare professional in a medical setting. - Myth: This medicine is the same as other antibiotics and can be substituted.
Fact: This medicine contains a specific combination of cefotaxime and sulbactam. It should not be substituted with other antibiotics without your doctor's advice.
🔄 Alternative Options
Generic Alternatives
- Cefotaxime + Sulbactam generic
Brand Alternatives
- Biotax SB 250 mg/125 mg injection