Betapro Plus Capsule SR: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Very slow pulse or fainting
- Chest pain or palpitations
- Difficulty breathing or wheezing
- Severe dizziness or lightheadedness
- New tremors, stiffness, or difficulty walking
- Yellowing of skin or eyes
- Severe rash or blistering of skin
If experiencing severe symptoms, call emergency services immediately.
What is betakon plus 40mg/5mg tablet used for?
This medicine is a combination of propranolol 40 mg and flunarizine 5 mg used for migraine prevention in adults. It is taken once daily at bedtime and works by stabilising blood vessels and reducing nerve excitability. It is not for acute migraine attacks.
- Generic Name: Propranolol (40mg) + Flunarizine (5mg)
- Manufacturer: Ikon Pharmachem Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 betakon plus 40mg/5mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा प्रोप्रानोलोल 40 मिलीग्राम और फ्लूनारिज़ीन 5 मिलीग्राम का संयोजन है, जिसका उपयोग माइग्रेन के दौरे को रोकने के लिए किया जाता है। यह दवा माइग्रेन के दौरे की आवृत्ति और तीव्रता को कम करने में मदद करती है। इसे आमतौर पर रात में सोने से पहले एक बार लिया जाता है। यह दवा तीव्र माइग्रेन के दौरे के इलाज के लिए नहीं है। इसे डॉक्टर की सलाह के बिना शुरू या बंद नहीं करना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, थकान, चक्कर आना, हाथ-पैर ठंडे होना, और वजन बढ़ना शामिल हैं। कुछ लोगों को मतली या पेट में परेशानी भी हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन धीमी हृदय गति, सांस लेने में कठिनाई, या गंभीर चक्कर आने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे चबाएं या तोड़ें नहीं, पूरा निगल लें। शराब न पिएं क्योंकि इससे नींद और चक्कर बढ़ सकते हैं। जब तक पता न चले कि यह दवा आप पर कैसा असर करती है, वाहन न चलाएं। अचानक दवा बंद न करें, इससे हृदय संबंधी समस्याएं हो सकती हैं। नियमित रूप से डॉक्टर से जांच कराएं।
💊 betakon plus 40mg/5mg tablet Uses & Benefits
[{"condition":"Migraine prophylaxis","description":"This medicine is used to reduce the frequency, severity, and duration of migraine attacks in adults when a single preventive agent is not sufficient.","evidence":"Well-established for propranolol; flunarizine is also established in migraine prevention in many countries."},{"condition":"Vascular headache syndromes","description":"Sometimes prescribed for recurrent vascular headaches where beta-blockade and calcium-channel modulation are considered beneficial.","evidence":"Limited, based on clinical experience and small studies."},{"condition":"Essential tremor with coexisting migraine","description":"Propranolol component may help tremor while flunarizine addresses migraine prevention in selected patients.","evidence":"Limited for the combination; propranolol alone is well-established for essential tremor."}]
Off-label uses: [{"condition":"Anxiety with migraine","description":"Propranolol is sometimes used off-label for performance anxiety and somatic anxiety symptoms, which may benefit patients who also have migraine.","evidence":"Limited"},{"condition":"Prophylaxis of vestibular migraine","description":"Flunarizine has been used off-label for vestibular migraine prevention in some clinical settings.","evidence":"Limited"}]
Primary treatment for: Migraine prophylaxis
Also treats: Vascular headache syndromes, Essential tremor with migraine
📋 Drug Information
| Generic Name(s) | Propranolol (40mg) + Flunarizine (5mg) |
| Brand Name | betakon plus 40mg/5mg tablet |
| Manufacturer | Ikon Pharmachem Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C in a dry place, away from direct sunlight and moisture. Keep the capsule in its original blister pack or container until it is time to take it. Do not refrigerate unless specifically instructed. Keep out of reach of children and pets. |
| Shelf Life | The shelf life is typically 24 months from the date of manufacture, but refer to the expiry date printed on the packaging. Do not use the medicine after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Propranolol is a non-selective beta-adrenergic receptor antagonist that blocks beta-1 and beta-2 receptors, reducing heart rate, cardiac output, and renin release, and it also has membrane-stabilising activity. Flunarizine is a selective calcium-channel blocker that inhibits calcium influx into vascular smooth muscle and neurons, reducing vasospasm and neuronal hyperexcitability. In migraine prophylaxis, the combination is thought to stabilise cerebrovascular tone and reduce cortical spreading depression, thereby lowering attack frequency.
Mechanism Steps
💡 How to Take betakon plus 40mg/5mg tablet
Strength: Sustained-release capsule containing propranolol 40 mg and flunarizine 5 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one capsule taken orally once daily, preferably at bedtime to minimise daytime drowsiness. The dose may be adjusted by your doctor based on your response and tolerability. Some patients may require a different dose or frequency. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and concomitant medications. Do not change the dose without consulting your doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially drowsiness, dizziness, and extrapyramidal symptoms. Start with a lower dose and titrate slowly under close medical supervision. Regular monitoring of heart rate, blood pressure, and neurological status is recommended. |
| Renal Impairment | Dose adjustment may be necessary in patients with severe renal impairment. Monitor renal function and adjust the dose as advised by your doctor. |
| Hepatic Impairment | Dose reduction is recommended in patients with hepatic impairment because propranolol and flunarizine are extensively metabolised in the liver. Monitor liver function tests and adjust the dose under medical supervision. |
| Maximum Daily Dose | The maximum recommended daily dose is one capsule (propranolol 40 mg + flunarizine 5 mg). Do not exceed the prescribed dose unless directed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of betakon plus 40mg/5mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Verapamil | Major | |
| Digoxin | Major | |
| Clonidine | Major | |
| MAOIs | Major | |
| Fluoxetine | Major | |
| NSAIDs | Moderate | |
| Insulin | Moderate | |
| Warfarin | Moderate | |
| Alcohol | Moderate | |
| Cimetidine | Minor |
🚨 Major Interactions
- Verapamil and diltiazem
- Digoxin
- Clonidine
- Monoamine oxidase inhibitors (MAOIs)
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
⚡ Moderate Interactions
- Non-steroidal anti-inflammatory drugs (NSAIDs)
- Oral hypoglycaemics and insulin
- Thyroid hormones
- Warfarin
- Alcohol
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Both propranolol and flunarizine can cause drowsiness and dizziness, and alcohol amplifies these central nervous system effects. Alcohol can also cause vasodilation and drop blood pressure further, leading to fainting. Additionally, alcohol may interfere with the metabolism of propranolol and increase the risk of liver toxicity. If you choose to drink, do so only in moderation and never drive or operate machinery.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to propranolol, flunarizine, or any component of the formulation","Asthma or severe chronic obstructive pulmonary disease","Severe bradycardia or second- or third-degree heart block","Cardiogenic shock or decompensated heart failure","Severe hypotension","Peripheral vascular disease with rest pain or gangrene","Pregnancy and breastfeeding unless specifically advised by a doctor"]
⚠️ Warnings & Precautions
["Do not stop this medicine abruptly, as it can worsen angina, cause rebound hypertension, or precipitate a heart attack.","Use with caution in patients with diabetes, as propranolol may mask hypoglycaemia symptoms.","May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Use with caution in patients with depression or a history of psychiatric disorders.","Flunarizine can cause extrapyramidal symptoms, especially in the elderly; monitor closely.","Avoid alcohol and other central nervous system depressants.","Inform your doctor if you have a history of psoriasis, as beta-blockers can worsen it.","Use with caution in patients with myasthenia gravis, as beta-blockers can worsen muscle weakness."]
🤱 Lactation Safety
Propranolol is excreted in breast milk in small amounts and is generally considered compatible with breastfeeding, but monitoring the infant for bradycardia and hypoglycaemia is advised. Flunarizine is also excreted in breast milk, and due to its long half-life and potential for sedation, it is not recommended during breastfeeding. Consult your doctor to weigh the benefits and risks before breastfeeding while on this medicine.
💊 Overdose Management
Overdose of this medicine can cause severe bradycardia, hypotension, heart failure, bronchospasm, and central nervous system depression. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and may include activated charcoal if ingestion is recent, intravenous fluids, atropine for bradycardia, vasopressors for hypotension, and glucagon for refractory bradycardia. Dialysis is not effective for removing propranolol or flunarizine. Do not attempt to induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember if less than half the dosing interval has passed. If more than half the interval has passed, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up. If you are unsure, contact your doctor or pharmacist for guidance.
Additional Safety Advice
Take this medicine exactly as prescribed, usually once daily at bedtime to reduce daytime drowsiness. Do not crush, chew, or open the sustained-release capsule; swallow it whole with water. Avoid alcohol because it can worsen drowsiness and low blood pressure. Do not drive or operate heavy machinery until you know how this medicine affects you. Do not stop this medicine suddenly, especially if you have heart disease, because abrupt withdrawal of propranolol can worsen angina or blood pressure. Inform your doctor about all other medicines, especially those for blood pressure, heart rhythm, diabetes, or depression. Keep regular follow-up appointments for blood pressure, heart rate, and neurological checks. Store this medicine in its original container at room temperature, away from moisture and direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more susceptible to the sedative and extrapyramidal effects of flunarizine and the cardiovascular effects of propranolol. Start with a lower dose and monitor closely for dizziness, falls, and movement disorders.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy or when planning pregnancy. Discuss alternative migraine treatments with your doctor before conception. Use effective contraception while taking this medicine.
🏥 Post-Surgery Considerations
Inform your surgeon and anaesthesiologist that you are taking this medicine. Beta-blockers may interact with anaesthetic agents and affect heart rate and blood pressure during surgery. Do not stop the medicine without your doctor's advice.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine, as it can interact with local anaesthetics containing adrenaline and affect blood pressure. Your dentist may need to adjust the anaesthetic used.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe, but this medicine can reduce exercise tolerance and cause fatigue or dizziness. Avoid strenuous exercise initially until you know how the medicine affects you. Stay hydrated and avoid overheating.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, especially when you first start taking it. Avoid driving or operating heavy machinery until you know how it affects you. It may affect your ability to concentrate. Discuss with your employer if your work requires alertness.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience serious side effects or your doctor decides to discontinue, the dose should be tapered gradually to avoid withdrawal effects such as rebound hypertension, tachycardia, or worsening angina.
📅 Long-Term Use Effects
Long-term use of this medicine may require periodic monitoring of heart rate, blood pressure, liver function, and neurological status. Flunarizine can accumulate in the body and cause extrapyramidal symptoms, especially in the elderly. Propranolol may mask hypoglycaemia in diabetics. Regular follow-up with your doctor is essential to assess the benefit-risk balance and to adjust the dose if needed.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help manage stress and reduce migraine frequency.
Evidence: ModerateHelps patients control physiological responses to stress.
Evidence: ModerateMay reduce migraine frequency in some patients.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform the healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss or temperature extremes. If crossing time zones, continue taking your dose at the same local time as at home, or adjust gradually as advised by your doctor. Store away from direct sunlight and moisture. Check customs regulations for controlled substances before travelling internationally.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: It may take 2-4 weeks of regular use to notice a reduction in migraine frequency. Full benefits may take up to 3 months.
A: No, this medicine is for prevention. You should use your acute migraine treatment as prescribed by your doctor.
A: If less than 12 hours have passed, take it as soon as you remember. If more than 12 hours, skip it and continue your regular schedule. Do not double dose.
A: No, stopping suddenly can cause withdrawal effects. Always consult your doctor before stopping.
🤔 Common Patient Concerns
🔄 Substitutes for betakon plus 40mg/5mg tablet
View AllAlternative brands with exact same active ingredient:
-
stayhappi propranolol+flunarizine 40mg/5mg tabletSarvagunaushdhi Pvt Ltd ₹37.50 23.8% CHEAPER
-
fpmat ls 40mg/5mg tablet srMatteo Healthcare Pvt Ltd ₹48.75 1% CHEAPER
-
Razim 40mg/5mg TabletJpee Healthcare ₹58.00 17.8% COSTLIER
-
betapro-plus capsule srConsern Pharma Limited ₹59.10 20.1% COSTLIER
-
mighop ls 40mg/5mg tabletAnax Lifescience ₹60.00 21.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken during a migraine attack for immediate relief.
Fact: This medicine is for prevention, not acute treatment. It does not relieve an ongoing attack. - Myth: Once you feel better, you can stop this medicine.
Fact: Stopping suddenly can cause withdrawal effects. Always consult your doctor before stopping. - Myth: This medicine is safe for everyone with headaches.
Fact: It is not safe for people with asthma, heart block, or certain other conditions. A doctor's evaluation is essential.
🔄 Alternative Options
Generic Alternatives
- Propranolol 40 mg + Flunarizine 5 mg sustained-release capsules from other manufacturers
Brand Alternatives
- Betapro Plus
- Migrabeta Plus
- Provanol Plus