best vg 100mg/100mg vaginal capsule - Clindamycin (100mg) + Clotrimazole (100mg) medicine

best vg 100mg/100mg vaginal capsule - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Brostin Seizz Biocare ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 27, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jun 27, 2026

What is best vg 100mg/100mg vaginal capsule used for?

Applygen Soft Gelatin Vaginal Suppositories (Clindamycin + Clotrimazole) is used to treat ANTI INFECTIVES. It contains Clindamycin (100mg) + Clotrimazole (100mg), which Clindamycin inhibits bacterial protein synthesis by binding to 50S ribosomal sub. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Clindamycin + Clotrimazole
  • Manufacturer: Brostin Seizz Biocare
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

๐Ÿ’Š best vg 100mg/100mg vaginal capsule Uses & Benefits

Bacterial vaginosis, vulvovaginal candidiasis, mixed vaginal infections

Off-label uses: Prevention of post-surgical vaginal infections

๐Ÿ“‹ Drug Information

Generic Name(s)Clindamycin + Clotrimazole
Brand NameApplygen Soft Gelatin Vaginal Suppositories
ManufacturerBrostin Seizz Biocare
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI INFECTIVES
Action ClassAntibiotic + Antifungal
Route of AdministrationVaginal
StorageStore at 20-25ยฐC (68-77ยฐF); protect from light and moisture
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionMinimal systemic absorption via vaginal mucosa
DistributionLocal distribution in vaginal tissues
Protein BindingClindamycin: 90-94%; Clotrimazole: 90%
MetabolismClindamycin: Hepatic via CYP3A4; Clotrimazole: Hepatic
Half-LifeClindamycin: 2-3 hours; Clotrimazole: 3-6 hours
ExcretionClindamycin: Renal and biliary; Clotrimazole: Feces
BioavailabilityLow systemic bioavailability due to local application
Onset of ActionWithin 24-48 hours
Peak Plasma TimeNot applicable (local action)
Duration of ActionUp to 7 days

How It Works

Clindamycin inhibits bacterial protein synthesis by binding to 50S ribosomal subunit; Clotrimazole inhibits fungal ergosterol synthesis by inhibiting 14ฮฑ-demethylase

Mechanism Steps

1Clindamycin binds to 50S ribosomal subunit of bacteria, inhibiting peptide bond formation and protein synthesis
2Clotrimazole inhibits fungal cytochrome P450 14ฮฑ-demethylase, blocking conversion of lanosterol to ergosterol
3Ergosterol depletion disrupts fungal cell membrane integrity, leading to cell death

๐Ÿ’ก How to Take best vg 100mg/100mg vaginal capsule

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of best vg 100mg/100mg vaginal capsule

โœ… Common Side Effects

  • Vaginal burning
  • itching
  • irritation
  • abdominal cramps

๐Ÿšจ Serious Side Effects

  • Pseudomembranous colitis
  • severe allergic reactions

โš ๏ธ Rare Side Effects

  • Hepatotoxicity
  • Stevens-Johnson syndrome

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Major Increased bleeding risk
Neuromuscular blockers Major Enhanced neuromuscular blockade

๐Ÿšจ Major Interactions

  • Neuromuscular blocking agents
  • Warfarin

โšก Moderate Interactions

  • CYP3A4 inhibitors
  • CYP3A4 inducers

โ„น๏ธ Minor Interactions

  • Oral contraceptives

๐Ÿฝ๏ธ Food Interactions

No significant food interactions

๐Ÿท Alcohol Interaction

No known interaction

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to clindamycin, clotrimazole, or any component; history of pseudomembranous colitis

๐Ÿ“Š Monitoring Parameters

Clinical response, signs of superinfection, hypersensitivity reactions

๐Ÿคฑ Lactation Safety

Use with caution; minimal systemic absorption

๐Ÿ’Š Overdose Management

Unlikely due to local use; symptomatic treatment if ingested

โฐ Missed Dose

Insert as soon as remembered; skip if near next dose; do not double dose

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 27, 2026

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