Cardace H 5 Tablet: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, tongue, or throat (angioedema)
- Difficulty breathing or swallowing
- Severe dizziness or fainting
- Decreased urine output or swelling in legs
- Irregular heartbeat or palpitations
- Severe abdominal pain radiating to the back
- Yellowing of skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is beepril-h 5mg/12.5mg tablet used for?
This medicine is a combination of Ramipril and Hydrochlorothiazide used to treat high blood pressure. It works by relaxing blood vessels and removing excess fluid from the body. It is taken orally once daily as prescribed by a doctor.
- Generic Name: Ramipril + Hydrochlorothiazide
- Manufacturer: Bonsai Pharma
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 beepril-h 5mg/12.5mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा रामिप्रिल और हाइड्रोक्लोरोथियाजाइड का संयोजन है, जिसका उपयोग उच्च रक्तचाप (हाइपरटेंशन) के इलाज के लिए किया जाता है। यह रक्त वाहिकाओं को आराम देकर और शरीर से अतिरिक्त तरल और नमक को बाहर निकालकर रक्तचाप को कम करती है। यह आमतौर पर तब दी जाती है जब अकेली दवा से रक्तचाप नियंत्रित नहीं होता। यह दवा डॉक्टर के पर्चे के बिना नहीं लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में चक्कर आना, सिरदर्द, थकान, और सूखी खांसी शामिल हैं। कुछ लोगों को पेशाब में वृद्धि, प्यास, और मांसपेशियों में ऐंठन हो सकती है। गंभीर दुष्प्रभावों में चेहरे, होंठ, जीभ या गले में सूजन (एंजियोएडेमा), गंभीर निम्न रक्तचाप, और गुर्दे की समस्या शामिल हैं। यदि आपको कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के बताए अनुसार ही लें। दवा की खुराक बदलें या बंद करने से पहले डॉक्टर से सलाह लें। इसे रोज सुबह एक ही समय पर लें। पर्याप्त पानी पिएं। शराब से बचें क्योंकि इससे चक्कर और निम्न रक्तचाप बढ़ सकता है। यदि आप गर्भवती हैं या गर्भधारण की योजना बना रही हैं तो डॉक्टर को बताएं। नियमित रूप से रक्तचाप, गुर्दे की कार्यप्रणाली और इलेक्ट्रोलाइट्स की जांच कराएं।
💊 beepril-h 5mg/12.5mg tablet Uses & Benefits
- [{"condition":"Essential hypertension","description":"This medicine is used to lower high blood pressure when a single agent is insufficient.
- It combines the blood-pressure-lowering effects of an ACE inhibitor and a thiazide diuretic.","evidence":"Well-established"},{"condition":"Heart failure (selected patients)","description":"Ramipril component may be used in heart failure to improve survival and reduce hospitalizations, but the combination with hydrochlorothiazide is not typically first-line for this indication.","evidence":"Well-established for Ramipril alone"},{"condition":"Post-myocardial infarction (selected patients)","description":"Ramipril is used after a heart attack to reduce the risk of further cardiovascular events.
- The combination product may be used if additional blood pressure control is needed.","evidence":"Well-established for Ramipril alone"}]
Off-label uses: [{"condition":"Diabetic nephropathy","description":"ACE inhibitors like Ramipril are sometimes used to protect kidney function in diabetic patients with proteinuria, but the combination with hydrochlorothiazide is not standard for this purpose.","evidence":"Limited"},{"condition":"Scleroderma renal crisis","description":"ACE inhibitors are used off-label for scleroderma renal crisis, but the combination with a diuretic is not typically recommended.","evidence":"Limited"}]
Primary treatment for: Hypertension
Also treats: Heart failure, Post-myocardial infarction
📋 Drug Information
| Generic Name(s) | Ramipril + Hydrochlorothiazide |
| Brand Name | Beepril-H 5mg/12.5mg Tablet |
| Manufacturer | Bonsai Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | ACE inhibitor + Thiazide diuretic |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and light. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization recommends ACE inhibitors or thiazide diuretics as first-line treatment for hypertension in adults, but the combination may be used when monotherapy is insufficient. Guidelines should be followed as per local protocols. |
| ICMR Guideline | The Indian Council of Medical Research recommends ACE inhibitors and thiazide diuretics for the management of hypertension in India, with combination therapy for patients not controlled on monotherapy. Regular monitoring is advised. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Ramipril is a prodrug that is converted in the liver to ramiprilat, which inhibits the angiotensin-converting enzyme (ACE). This inhibition prevents the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, leading to vasodilation and reduced aldosterone secretion. The result is lower blood pressure and reduced sodium and water retention. Hydrochlorothiazide is a thiazide diuretic that inhibits the sodium-chloride symporter in the distal convoluted tubule of the kidney, increasing the excretion of sodium, chloride, and water. This reduces plasma volume and cardiac output initially, and later lowers peripheral vascular resistance. Together, these actions effectively lower blood pressure and reduce cardiovascular risk.
Mechanism Steps
💡 How to Take beepril-h 5mg/12.5mg tablet
Strength: Immediate-release tablet containing Ramipril 5 mg and Hydrochlorothiazide 12.5 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet (Ramipril 5 mg + Hydrochlorothiazide 12.5 mg) taken orally once daily. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and response to therapy. Some patients may require a lower starting dose, especially if volume-depleted or elderly. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. Start with a lower dose and monitor closely for hypotension, dizziness, and electrolyte imbalances. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with renal impairment, dose adjustments may be necessary. Ramipril is contraindicated in severe renal impairment (creatinine clearance <30 mL/min). Hydrochlorothiazide may be less effective in renal impairment. Consult a nephrologist for individualized dosing. |
| Hepatic Impairment | In patients with hepatic impairment, Ramipril may require dose reduction. Hydrochlorothiazide should be used with caution. Monitor liver function. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet (Ramipril 5 mg + Hydrochlorothiazide 12.5 mg) once daily. Higher doses may be prescribed by a clinician based on individual patient needs, but should not exceed the maximum recommended doses of individual components. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of beepril-h 5mg/12.5mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Potassium supplements | Major | |
| Lithium | Major | |
| NSAIDs | Major | |
| Other antihypertensives | Major | |
| Corticosteroids | Moderate | |
| Digoxin | Moderate | |
| Oral hypoglycemics | Moderate | |
| Cholestyramine | Moderate | |
| Antacids | Minor | |
| Carbamazepine | Minor |
🚨 Major Interactions
- Potassium supplements or potassium-sparing diuretics
- Lithium
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
- Other antihypertensive agents
⚡ Moderate Interactions
- Corticosteroids
- Digoxin
- Oral hypoglycemics
- Cholestyramine and colestipol
🍷 Alcohol Interaction
Alcohol may enhance the blood pressure-lowering effect of this medicine, leading to dizziness, lightheadedness, and fainting. It is advisable to avoid alcohol or limit intake while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["History of angioedema related to ACE inhibitors","Anuria","Severe renal impairment (creatinine clearance
⚠️ Warnings & Precautions
["Monitor for angioedema; discontinue immediately if suspected.","Avoid use in patients with bilateral renal artery stenosis.","Use caution in patients with collagen vascular disease.","May cause symptomatic hypotension, especially after first dose or volume depletion.","Monitor potassium levels; risk of hyperkalemia or hypokalemia.","May impair ability to drive or operate machinery.","Avoid in pregnancy; use effective contraception."]
🤱 Lactation Safety
Ramipril and hydrochlorothiazide are excreted in human breast milk in small amounts. Due to the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or discontinue the medicine, taking into account the importance of the medicine to the mother. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose may cause severe hypotension, electrolyte imbalances, and renal failure. Treatment is supportive and symptomatic. If ingestion is recent, consider activated charcoal. Monitor vital signs, electrolytes, and renal function. There is no specific antidote. Contact a poison control center or emergency department immediately.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without medical advice, as sudden discontinuation can cause a rebound increase in blood pressure. Take the tablet at the same time each day, preferably in the morning, to establish a routine. Stay well hydrated, especially if you experience increased urination. Avoid alcohol, as it can intensify dizziness and low blood pressure. Inform your doctor if you have diabetes, gout, kidney or liver disease, or if you are planning to become pregnant. Use effective contraception while taking this medicine, and contact your doctor immediately if you suspect pregnancy. Avoid potassium supplements or salt substitutes containing potassium unless specifically instructed by your doctor. Regular blood tests to check kidney function, electrolytes, and blood pressure are important. Do not drive or operate heavy machinery if you feel dizzy or lightheaded.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more susceptible to the blood pressure-lowering effects and electrolyte imbalances caused by this medicine. Start with a lower dose and monitor closely for dizziness, falls, and kidney function. Regular follow-up is essential.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated during pregnancy. If you are planning to become pregnant, consult your doctor to switch to a safer alternative before conception. Use effective contraception while taking this medicine.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may need to be temporarily stopped before surgery to prevent low blood pressure during the procedure. Follow your doctor's instructions regarding when to resume.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine, as it may cause dry mouth or increase the risk of bleeding. Your dentist may need to take precautions during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is generally safe while taking this medicine, but avoid strenuous activities that may cause dehydration or excessive sweating, as this can lead to low blood pressure. Stay hydrated and monitor how you feel during exercise. Consult your doctor before starting a new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue, especially when you first start taking it. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their normal activities, but it is important to rise slowly from sitting or lying positions to prevent dizziness.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects such as angioedema, severe hypotension, or kidney problems, seek immediate medical attention. Your doctor may adjust the dose or switch to a different medication.
📅 Long-Term Use Effects
Long-term use of this medicine may require regular monitoring of kidney function, electrolytes, and blood pressure. It can effectively control hypertension and reduce cardiovascular risk. However, prolonged use may lead to electrolyte imbalances, kidney impairment, or gout. Regular follow-up with your doctor is essential to adjust the dose and manage any side effects.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet, exercise, and weight loss can help lower blood pressure and may reduce the need for medication.
Evidence: Well-establishedCalcium channel blockers, beta-blockers, or angiotensin receptor blockers may be alternatives if this medicine is not tolerated.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, consult your doctor before receiving any live vaccines, as your immune response may be affected. Routine vaccinations are generally safe.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If crossing time zones, consult your doctor about adjusting the dosing schedule. Check local customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The blood pressure-lowering effect begins within a few hours, but the full effect may take several weeks. Your doctor will monitor your progress.
A: Yes, you can take it with or without food. Taking it with food may reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: No, this medicine is contraindicated during pregnancy as it can harm the fetus. Use effective contraception and consult your doctor if you plan to become pregnant.
🤔 Common Patient Concerns
🔄 Substitutes for beepril-h 5mg/12.5mg tablet
View AllAlternative brands with exact same active ingredient:
-
StayHappi Ramipril+Hydrochlorothiazide 5mg/12.5mg TabletSarvagunaushdhi Pvt Ltd ₹28.13 43.7% CHEAPER
-
Ramp H TabletWest-Coast Pharmaceutical Works Ltd ₹30.00 40% CHEAPER
-
Rip H 5mg/12.5mg TabletDivine Savior Pvt Ltd ₹45.00 10% CHEAPER
-
Reopres H 5mg/12.5mg TabletPulse Pharmaceuticals ₹48.75 2.5% CHEAPER
-
servace h 5mg/12.5mg tabletBal Pharma Ltd ₹53.16 6.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be stopped once blood pressure is normal.
Fact: High blood pressure often requires long-term treatment. Stopping suddenly can cause a dangerous rise in blood pressure. Always consult your doctor before stopping. - Myth: This medicine causes kidney damage in everyone.
Fact: While kidney function should be monitored, this medicine is used to protect kidneys in some patients. Regular monitoring helps prevent problems. - Myth: You can take this medicine without a prescription.
Fact: This is a prescription medicine. It should only be taken under medical supervision.
🔄 Alternative Options
Generic Alternatives
- Ramipril + Hydrochlorothiazide generic tablets
Brand Alternatives
- Cardace H 5 Tablet