Azopip 4.5gm Injection - Uses, Price, Side Effects
What is azopip 4.5gm injection used for?
Azopip 4.5gm Injection is a combination antibiotic containing Piperacillin (4000mg) and Tazobactam (500mg). It is used to treat moderate to severe bacterial infections including pneumonia, intra-abdominal infections, and urinary tract infections. Piperacillin kills bacteria by inhibiting cell wall synthesis, while Tazobactam prevents bacterial resistance by inhibiting beta-lactamase enzymes.
- Generic Name: Piperacillin + Tazobactam
- Manufacturer: Asterisk Laboratories India Pvt Ltd
- Form: Allopathy
- Pregnancy Category: B
- Prescription Required: Yes
๐ azopip 4.5gm injection Uses & Benefits
Intra-abdominal infections, urinary tract infections, respiratory tract infections, skin and soft tissue infections, septicemia, febrile neutropenia.
Off-label uses: Bone and joint infections, Endocarditis, Meningitis
๐ Drug Information
| Generic Name(s) | Piperacillin + Tazobactam |
| Brand Name | Ahentaz 4.5 Injection |
| Manufacturer | Asterisk Laboratories India Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Penicillin antibiotic with beta-lactamase inhibitor |
| Route of Administration | Intravenous (IV) infusion |
| Storage | Store at 20-25ยฐC (68-77ยฐF); reconstituted solution stable for 24 hours at room temperature or 48 hours under refrigeration. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Piperacillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs); Tazobactam irreversibly inhibits beta-lactamases, protecting piperacillin from degradation.
Mechanism Steps
๐ก How to Take azopip 4.5gm injection
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of azopip 4.5gm injection
โ Common Side Effects
- Diarrhea
- Nausea
- Vomiting
- Headache
- Insomnia
- Rash
๐จ Serious Side Effects
- Anaphylaxis
- Stevens-Johnson syndrome
- Clostridioides difficile diarrhea
- Acute renal failure
- Hepatitis
โ ๏ธ Rare Side Effects
- Agranulocytosis
- Hemolytic anemia
- Seizures
- Pseudomembranous colitis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Methotrexate | Moderate | Increased methotrexate toxicity |
| Probenecid | Moderate | Reduced excretion of piperacillin |
| Vecuronium | Moderate | Prolonged neuromuscular blockade |
๐จ Major Interactions
- Warfarin
- Methotrexate
- Vecuronium
- Probenecid
โก Moderate Interactions
- Oral contraceptives
- Cyclosporine
- Tacrolimus
โน๏ธ Minor Interactions
- Heparin
- NSAIDs
๐ท Alcohol Interaction
No direct interaction, but alcohol may increase side effects like nausea.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to penicillins, cephalosporins, or beta-lactamase inhibitors.
๐ Monitoring Parameters
Renal function, hepatic function, CBC, signs of hypersensitivity, bleeding, superinfection.
๐คฑ Lactation Safety
Excreted in breast milk in low amounts; use with caution.
๐ Overdose Management
Supportive care; hemodialysis may enhance elimination.
โฐ Missed Dose
Administer as soon as possible; do not double dose.