Azidone SB 500mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe allergic reaction: swelling of face, lips, tongue, or throat, difficulty breathing.
- Signs of liver injury: yellowing of skin or eyes, dark urine, severe abdominal pain.
- Heart rhythm changes: palpitations, dizziness, fainting, irregular heartbeat.
- Severe skin reactions: painful rash, blistering, peeling skin.
- Severe diarrhoea with fever or abdominal cramps, which may indicate C. difficile infection.
- Unusual bleeding or bruising.
- Hearing loss or ringing in the ears.
If experiencing severe symptoms, call emergency services immediately.
What is azidone sb 500mg tablet used for?
This medicine is a combination of azithromycin, an antibiotic, and Saccharomyces boulardii, a probiotic. It is used to treat bacterial infections while helping to prevent antibiotic-associated diarrhoea. Take it exactly as prescribed, usually once daily for 3 to 5 days.
- Generic Name: Azithromycin (500mg) + Saccharomyces boulardii (2Million spores)
- Manufacturer: Femgrace Formulations
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 azidone sb 500mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एज़िथ्रोमाइसिन और सैकरोमाइसेस बौलार्डी का संयोजन है। एज़िथ्रोमाइसिन एक एंटीबायोटिक है जो बैक्टीरियल संक्रमणों जैसे निमोनिया, साइनसाइटिस, गले में संक्रमण, त्वचा संक्रमण और क्लैमाइडिया संक्रमण के इलाज में उपयोग किया जाता है। सैकरोमाइसेस बौलार्डी एक प्रोबायोटिक है जो एंटीबायोटिक से होने वाले दस्त को रोकने में मदद करता है। यह दवा डॉक्टर के पर्चे के बिना न लें।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, दस्त, पेट दर्द और सिरदर्द शामिल हैं। ये आमतौर पर हल्के और अस्थायी होते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें एलर्जी, यकृत की समस्या, दिल की धड़कन में गड़बड़ी और गंभीर त्वचा प्रतिक्रियाएं शामिल हो सकती हैं। यदि आपको कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। पूरा कोर्स पूरा करें, भले ही आप बेहतर महसूस करें। एंटासिड के साथ लेने से बचें, कम से कम 2 घंटे का अंतर रखें। यदि आपको दिल, यकृत, गुर्दे की बीमारी है या आप गर्भवती हैं तो डॉक्टर को बताएं। शराब का सेवन न करें। दवा को कमरे के तापमान पर सूखी जगह पर रखें।
💊 azidone sb 500mg tablet Uses & Benefits
[{"condition":"Community-acquired pneumonia","description":"Used to treat mild to moderate community-acquired pneumonia caused by susceptible organisms such as Streptococcus pneumoniae, Haemophilus influenzae, and Mycoplasma pneumoniae.","evidence":"Well-established"},{"condition":"Acute bacterial sinusitis","description":"Effective against bacterial sinusitis when caused by susceptible bacteria, often as an alternative for patients allergic to penicillin.","evidence":"Well-established"},{"condition":"Pharyngitis/tonsillitis","description":"Used for streptococcal pharyngitis in patients who cannot take penicillin.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats uncomplicated skin infections such as cellulitis, erysipelas, and impetigo caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Urethritis/cervicitis due to Chlamydia trachomatis","description":"A single 1 g dose is standard for uncomplicated chlamydial infection.","evidence":"Well-established"},{"condition":"Acute otitis media","description":"Used when first-line antibiotics are not suitable, in patients with susceptible organisms.","evidence":"Well-established"},{"condition":"Acute exacerbation of chronic bronchitis","description":"May be used for bacterial exacerbations, though not first-line in all guidelines.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Malaria (in combination)","description":"Sometimes used off-label with other antimalarials for uncomplicated malaria, but not standard.","evidence":"Limited"},{"condition":"Cystic fibrosis (chronic airway infection)","description":"Azithromycin is used off-label for its anti-inflammatory and immunomodulatory effects in cystic fibrosis.","evidence":"Moderate"},{"condition":"Bronchiolitis obliterans syndrome","description":"Off-label use in lung transplant patients for immunomodulation.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Community-acquired pneumonia, Acute bacterial sinusitis, Pharyngitis/tonsillitis, Skin and soft tissue infections, Chlamydial urethritis/cervicitis, Acute otitis media, Acute exacerbation of chronic bronchitis
📋 Drug Information
| Generic Name(s) | Azithromycin (500mg) + Saccharomyces boulardii (2Million spores) |
| Brand Name | azidone sb 500mg tablet |
| Manufacturer | Femgrace Formulations |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and light. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Azithromycin is included in the WHO Model List of Essential Medicines for the treatment of several bacterial infections, including sexually transmitted infections and respiratory tract infections. However, specific recommendations vary by condition and local resistance patterns. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) recommends azithromycin as an alternative for treating certain bacterial infections, including community-acquired pneumonia and enteric fever, based on local susceptibility data. It is not recommended for routine use in viral infections. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Azithromycin binds to the 50S ribosomal subunit of susceptible bacteria, inhibiting transpeptidation and translocation during protein synthesis, thereby stopping bacterial growth. Saccharomyces boulardii is a non-pathogenic yeast that exerts probiotic effects by inhibiting the growth of pathogenic bacteria, enhancing intestinal barrier function, and modulating the immune response, which helps prevent antibiotic-associated diarrhoea.
Mechanism Steps
💡 How to Take azidone sb 500mg tablet
Strength: Azithromycin 500 mg + Saccharomyces boulardii 2 million spores immediate-release tablet.
Dosage Information
| Adult Dosage | The usual adult dose of azithromycin for most infections is 500 mg once daily for 3 to 5 days, depending on the indication. For chlamydial urethritis or cervicitis, a single 1 g dose is often used. The Saccharomyces boulardii component is included to prevent antibiotic-associated diarrhoea. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more susceptible to QT prolongation and hepatic effects. No specific dose adjustment is required, but caution is advised. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No dose adjustment is needed for mild to moderate renal impairment. In severe renal impairment (creatinine clearance <10 mL/min), azithromycin should be used with caution. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | No specific dose adjustment is recommended for mild to moderate hepatic impairment. However, azithromycin should be used with caution in patients with severe hepatic impairment due to risk of hepatotoxicity. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose of azithromycin is 500 mg for most infections, except for chlamydial infection where a single 1 g dose is used. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of azidone sb 500mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Ergotamine | Major | |
| Amiodarone | Major | |
| Digoxin | Major | |
| Cyclosporine | Moderate | |
| Simvastatin | Moderate | |
| Fluconazole | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Ergot alkaloids (e.g., ergotamine, dihydroergotamine)
- Class IA and III antiarrhythmics (e.g., quinidine, procainamide, amiodarone, sotalol)
- Digoxin
- Antacids containing aluminium or magnesium
⚡ Moderate Interactions
- Cyclosporine
- HMG-CoA reductase inhibitors (statins)
- Nelfinavir
- Fluconazole
🍷 Alcohol Interaction
Alcohol may worsen gastrointestinal side effects such as nausea, vomiting, and abdominal pain. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic","History of cholestatic jaundice or hepatic dysfunction associated with prior azithromycin use","Severely immunocompromised patients (for Saccharomyces boulardii component)","Patients with central venous catheters (for Saccharomyces boulardii component)"]
⚠️ Warnings & Precautions
["Use with caution in patients with liver disease; monitor for signs of hepatotoxicity.","Use with caution in patients with QT prolongation or risk factors; consider ECG monitoring.","May exacerbate myasthenia gravis symptoms.","Avoid in patients with severe renal impairment (CrCl
🤱 Lactation Safety
Azithromycin is excreted in breast milk in small amounts and is generally considered compatible with breastfeeding. Saccharomyces boulardii is not systemically absorbed and is unlikely to affect the infant. Consult your doctor before use.
💊 Overdose Management
Overdose may cause severe nausea, vomiting, diarrhoea, and hearing loss. There is no specific antidote. Treatment is supportive and symptomatic. Contact a poison control centre or emergency department immediately if overdose is suspected.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not share it with others. Complete the full course even if you feel better. Inform your doctor if you have heart rhythm problems, liver disease, kidney disease, myasthenia gravis, or a weakened immune system. Avoid taking antacids containing aluminium or magnesium within 2 hours of this medicine. Tell your doctor about all other medicines you are taking, especially blood thinners, digoxin, ergot alkaloids, and other antibiotics. Do not use this medicine if you are allergic to macrolide antibiotics. If you develop severe diarrhoea, stop the medicine and seek medical advice. Pregnant or breastfeeding women should consult their doctor before use. Store at room temperature away from moisture and heat.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to QT prolongation, liver toxicity, and hearing loss. Use with caution and monitor for side effects. No specific dose adjustment is required, but individualization is advised.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. Azithromycin is generally considered safe, but the probiotic component should be discussed with your healthcare provider.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, inform your surgeon about this medicine. It may interact with anaesthetics or other medications used during surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may interact with other medications or affect healing.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
You may continue light exercise if you feel up to it, but avoid strenuous activity while you are recovering from an infection. Listen to your body and rest when needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
Most people can continue their daily activities while taking this medicine. If you experience dizziness or blurred vision, avoid driving or operating heavy machinery until you feel better.
🛑 When to Stop This Medicine
Stop taking this medicine and contact your doctor immediately if you experience signs of a severe allergic reaction, liver problems, irregular heartbeat, or severe diarrhoea. Do not stop the course early unless instructed by your doctor.
📅 Long-Term Use Effects
Long-term use of azithromycin is not recommended unless for specific chronic conditions like cystic fibrosis. Prolonged use may lead to bacterial resistance, superinfections, and rare liver or heart complications. Regular monitoring may be required if used for extended periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the infection, other antibiotics such as amoxicillin, clarithromycin, or levofloxacin may be used.
Evidence: Well-establishedSeparate probiotic supplements can be taken alongside antibiotics to prevent diarrhoea.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Antibiotics do not interact with vaccines. However, if you are scheduled to receive a live bacterial vaccine (e.g., typhoid Ty21a), antibiotics may reduce its effectiveness. Consult your doctor for timing.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If travelling across time zones, adjust dosing times gradually to maintain consistent intervals. Check customs regulations for carrying prescription medicines. Keep a list of your medications and allergies with you.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24 to 48 hours, but it is important to complete the full course as prescribed.
A: Yes, you can take it with or without food. If it upsets your stomach, take it with a meal.
A: Take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: Azithromycin is generally considered safe during pregnancy when clearly needed. Consult your doctor before use.
A: It is advisable to avoid alcohol as it may worsen gastrointestinal side effects.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: Azithromycin can cure the common cold.
Fact: Azithromycin is an antibiotic and is ineffective against viruses, including the common cold. - Myth: You can stop taking the antibiotic once you feel better.
Fact: You must complete the full prescribed course to prevent bacterial resistance and relapse. - Myth: Probiotics in antibiotics are unnecessary.
Fact: Saccharomyces boulardii helps prevent antibiotic-associated diarrhoea by protecting gut flora. - Myth: Azithromycin is safe for everyone.
Fact: It is contraindicated in patients with macrolide allergy and those with certain heart or liver conditions.
🔄 Alternative Options
Generic Alternatives
- Azithromycin 500 mg tablet + Saccharomyces boulardii 2 million spores capsule
- Azithromycin 500 mg tablet (alone) with separate probiotic supplement
Brand Alternatives
- Azee 500
- Azithral 500
- Zithromax 500
- Azax 500
- Azibact 500