Azicox CF Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, tongue, or throat, or difficulty breathing
- Severe or bloody diarrhea, or diarrhea with fever and stomach cramps
- Yellowing of the skin or eyes, dark urine, or severe abdominal pain
- Palpitations, fainting, or seizures
- Unusual bleeding or bruising
- Decreased urine output or swelling in the legs
- Severe skin rash with blisters or peeling
- Persistent high fever despite taking the medicine for 3 days
If experiencing severe symptoms, call emergency services immediately.
What is azicox cf tablet used for?
This medicine is a prescription antibiotic combination of Cefixime 250 mg and Azithromycin 200 mg used to treat various bacterial infections. It works by killing bacteria through two different mechanisms. It should be taken exactly as prescribed, usually twice daily, and the full course must be completed even if symptoms improve.
- Generic Name: Cefixime + Azithromycin
- Manufacturer: Coxswain Healthcare
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 azicox cf tablet के बारे में (Hindi Summary)
उपयोग: यह दवा सेफिक्सिम 250 मिलीग्राम और एज़िथ्रोमाइसिन 200 मिलीग्राम का संयोजन है, जिसका उपयोग विभिन्न जीवाणु संक्रमणों के इलाज के लिए किया जाता है। यह श्वसन तंत्र के संक्रमण जैसे ब्रोंकाइटिस, निमोनिया, कान का संक्रमण, साइनसाइटिस, गले का संक्रमण और कुछ यौन संचारित संक्रमणों के लिए निर्धारित की जाती है। यह दवा केवल डॉक्टर के पर्चे पर ही लेनी चाहिए और पूरा कोर्स पूरा करना चाहिए, भले ही लक्षण ठीक हो जाएं।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में दस्त, मतली, उल्टी, पेट दर्द, सिरदर्द और त्वचा पर चकत्ते शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन इनमें तेज एलर्जी प्रतिक्रिया, गंभीर दस्त, यकृत की समस्या और हृदय की धड़कन में गड़बड़ी शामिल हो सकती है। यदि आपको कोई भी असामान्य लक्षण दिखे, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी एलर्जी, चिकित्सीय स्थितियों और दवाओं के बारे में बताएं। इसे डॉक्टर के निर्देशानुसार ही लें और पूरा कोर्स पूरा करें। शराब का सेवन न करें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर से सलाह लें। दवा को बच्चों की पहुंच से दूर रखें।
💊 azicox cf tablet Uses & Benefits
- [{"condition":"Acute bacterial sinusitis","description":"Used to treat sinus infections caused by susceptible bacteria when a combination of antibiotics is considered appropriate.","evidence":"Well-established for appropriate bacterial infections"},{"condition":"Acute otitis media","description":"Prescribed for middle ear infections in patients who require broader antibiotic coverage.","evidence":"Well-established for appropriate bacterial infections"},{"condition":"Community-acquired pneumonia","description":"May be used for mild to moderate pneumonia caused by susceptible bacteria, often when atypical pathogens are suspected.","evidence":"Well-established for appropriate bacterial infections"},{"condition":"Acute exacerbation of chronic bronchitis","description":"Used to treat flare-ups of chronic bronchitis caused by bacterial infection.","evidence":"Well-established for appropriate bacterial infections"},{"condition":"Pharyngitis and tonsillitis","description":"Prescribed for bacterial throat infections when first-line antibiotics are not suitable or have failed.","evidence":"Well-established for appropriate bacterial infections"},{"condition":"Uncomplicated skin and soft tissue infections","description":"May be used for certain skin infections caused by susceptible bacteria.","evidence":"Limited to specific infections"},{"condition":"Urethritis and cervicitis","description":"Azithromycin component is effective against Chlamydia trachomatis and Neisseria gonorrhoeae; cefixime also covers gonorrhea.
- Combination may be used in specific scenarios.","evidence":"Well-established for specific pathogens"}]
Off-label uses: [{"condition":"Traveler's diarrhea","description":"Sometimes prescribed off-label for moderate to severe traveler's diarrhea caused by susceptible bacteria.","evidence":"Limited"},{"condition":"Dental infections","description":"May be used off-label for dental abscesses or pericoronitis when broader coverage is needed.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Respiratory tract infections, Otitis media, Sinusitis, Pharyngitis, Tonsillitis, Skin infections, Urethritis, Cervicitis
📋 Drug Information
| Generic Name(s) | Cefixime + Azithromycin |
| Brand Name | Azicef-LB Tablet |
| Manufacturer | Coxswain Healthcare |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporin antibiotic + Macrolide antibiotic |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container, tightly closed. Do not store in the bathroom. Keep out of reach of children and pets. |
| Shelf Life | Typically 24 months from the date of manufacture, but refer to the expiry date printed on the pack. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information for this specific combination. Guidelines for individual components exist for specific infections, but the combination is not universally recommended by WHO for all indications. |
| ICMR Guideline | Not established from the available information for this specific combination. ICMR guidelines for antimicrobial use should be consulted for specific infections. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antibiotics with different mechanisms of action. Cefixime, a third-generation cephalosporin, works by binding to specific penicillin-binding proteins (PBPs) inside the bacterial cell wall. This binding inhibits the cross-linking of peptidoglycan chains, which are essential for the strength and rigidity of the bacterial cell wall. As a result, the bacterial cell wall becomes weak and the bacterium eventually dies due to osmotic pressure. Cefixime is bactericidal, meaning it kills bacteria directly. Azithromycin, a macrolide antibiotic, works by binding to the 50S ribosomal subunit of the bacterial ribosome. This binding blocks the translocation step of protein synthesis, preventing the bacteria from making essential proteins needed for growth and multiplication. Azithromycin is generally bacteriostatic, meaning it stops bacteria from growing, but at higher concentrations it can also be bactericidal. The combination provides broad-spectrum coverage against many gram-positive and gram-negative bacteria, as well as atypical pathogens.
Mechanism Steps
💡 How to Take azicox cf tablet
Strength: Each immediate-release oral tablet contains Cefixime 250 mg and Azithromycin 200 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally twice daily, approximately every 12 hours, for a duration determined by your doctor based on the type and severity of infection. The typical course may range from 5 to 14 days. However, the exact dose and duration must be individualized by a qualified clinician based on the specific indication, the patient's age, weight, renal and hepatic function, and the susceptibility of the infecting organism. Do not self-adjust the dose. Always follow your doctor's prescription exactly. |
| Pediatric Dosage | Pediatric dosing is not established from available information for this specific combination tablet. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the side effects of this medicine, especially those related to kidney function, liver function, and heart rhythm. Dose adjustment may be necessary based on renal function. Elderly patients should be monitored closely for signs of toxicity. Always consult a doctor for appropriate dosing. |
| Renal Impairment | In patients with renal impairment, the dose of cefixime may need to be reduced. Azithromycin does not require dose adjustment in renal impairment. Consult your doctor for specific dosing recommendations based on creatinine clearance. Monitor renal function closely during treatment. |
| Hepatic Impairment | In patients with hepatic impairment, azithromycin should be used with caution due to its hepatic metabolism. Cefixime does not require significant dose adjustment in hepatic impairment. Consult your doctor for specific dosing recommendations. Monitor liver function tests if symptoms occur. |
| Maximum Daily Dose | The maximum recommended daily dose for adults is typically two tablets per day (i.e., 500 mg cefixime and 400 mg azithromycin). Do not exceed the prescribed dose. In severe infections, your doctor may prescribe a higher dose, but this must be strictly supervised. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of azicox cf tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Ergot alkaloids | Major | |
| QT-prolonging drugs | Major | |
| Carbamazepine | Moderate | |
| Cyclosporine | Moderate | |
| Antacids | Moderate | |
| Digoxin | Moderate | |
| Theophylline | Moderate | |
| Oral contraceptives | Moderate | |
| Live typhoid vaccine | Moderate |
🚨 Major Interactions
- Warfarin
- Ergot alkaloids (e.g., ergotamine, dihydroergotamine)
- QT-prolonging drugs (e.g., amiodarone, sotalol, quinidine, procainamide, some antipsychotics, some antidepressants)
- Carbamazepine
- Cyclosporine
⚡ Moderate Interactions
- Antacids containing aluminum or magnesium
- Digoxin
- Theophylline
- Oral contraceptives
- Live typhoid vaccine
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol can worsen stomach upset, nausea, and dizziness caused by the antibiotics. It may also increase the risk of liver problems, especially with azithromycin, which is metabolized by the liver. Additionally, alcohol can weaken your immune system and slow down your recovery from infection. It is best to abstain from alcohol until you have completed the course and your doctor confirms you are recovered.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or severe allergic reaction to cefixime, other cephalosporins, azithromycin, other macrolides, or any component of this medicine","History of severe allergic reaction to penicillins (due to potential cross-reactivity with cephalosporins)","Concurrent use with ergot alkaloids","Patients with a history of cholestatic jaundice or hepatic dysfunction associated with prior azithromycin use","Use in patients with myasthenia gravis (azithromycin may exacerbate symptoms)"]
⚠️ Warnings & Precautions
["Serious allergic reactions, including anaphylaxis, can occur. Discontinue immediately and seek emergency help if signs occur.","Clostridioides difficile-associated diarrhea can occur during or after treatment. Do not treat with anti-diarrheal medicines without medical advice.","Use with caution in patients with renal impairment; dose adjustment may be needed.","Use with caution in patients with liver disease; monitor liver function.","May cause QT prolongation; avoid in patients with risk factors or on other QT-prolonging drugs.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Do not use for viral infections; it is ineffective and promotes resistance.","Complete the full course as prescribed, even if symptoms improve.","May reduce the effectiveness of oral contraceptives; use backup contraception.","Avoid alcohol during treatment."]
🤱 Lactation Safety
Cefixime is excreted in human breast milk in small amounts and is generally considered compatible with breastfeeding. Azithromycin is also excreted in breast milk, and while it is generally considered safe, some infants may experience diarrhea or thrush. Consult your doctor before breastfeeding while taking this medicine. If you notice any changes in your baby's behavior or feeding habits, contact your pediatrician.
💊 Overdose Management
Overdose of this medicine may cause severe nausea, vomiting, diarrhea, and abdominal pain. In case of overdose, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if the overdose is recent and significant. Monitor vital signs, electrolytes, and renal function. Contact a poison control center for guidance.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. Try to take the medicine at the same times each day to maintain consistent levels in your body.
Additional Safety Advice
Before taking this medicine, inform your doctor if you are allergic to any antibiotics, especially penicillins or cephalosporins, or if you have ever had a severe allergic reaction to any medicine. Tell your doctor about all your medical conditions, particularly kidney or liver disease, heart rhythm problems, myasthenia gravis, or a history of colitis. This medicine can interact with several other drugs, so provide a complete list of all prescription, over-the-counter, and herbal products you are taking. Do not start or stop any medicine without your doctor's approval. Take this medicine exactly as prescribed, at evenly spaced intervals, and complete the full course even if you feel better. Do not share this medicine with others, and do not save leftover medicine for future use. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. Avoid alcohol while taking this medicine, as it can worsen stomach upset and dizziness. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before taking this medicine. This medicine may cause dizziness; avoid driving or operating heavy machinery until you know how it affects you. Keep this medicine out of the reach of children and store it as directed on the label.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function, which can affect the elimination of cefixime. Dose adjustment may be necessary. They are also at higher risk of QT prolongation and other cardiac side effects from azithromycin. Monitor renal and hepatic function, and watch for signs of confusion, dizziness, or falls. Ensure adequate hydration.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Both cefixime and azithromycin are generally considered safe during pregnancy when clearly needed, but the decision should be made by your doctor after weighing the benefits and risks. Use effective contraception during treatment if you are of childbearing potential, as antibiotics may reduce the effectiveness of hormonal contraceptives.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, inform your surgeon and anesthesiologist that you are taking this medicine. Antibiotics can interact with certain anesthetic agents and may affect wound healing. Your doctor may advise you to stop the medicine before surgery or adjust the dose. Do not stop without medical advice.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. Antibiotics can affect the balance of bacteria in the mouth and may interact with other medications used during dental work. Your dentist may recommend postponing non-urgent procedures until you complete the course. Maintain good oral hygiene to prevent dental infections.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may feel tired or dizzy. Avoid strenuous exercise until you feel fully recovered. Light activities like walking are fine if you feel up to it. Listen to your body and rest when needed. If you experience any chest pain, shortness of breath, or severe fatigue during exercise, stop immediately and consult your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, drowsiness, or blurred vision in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take breaks and stay hydrated. If your job involves physical labor, you may need to take it easy until you recover. Inform your employer if you need time off to rest and recover.
🛑 When to Stop This Medicine
Stop taking this medicine only after completing the full prescribed course, unless your doctor advises otherwise. If you experience a serious side effect such as a severe allergic reaction, severe diarrhea, or signs of liver problems, stop the medicine and seek immediate medical attention. Do not stop early just because you feel better, as this can lead to a relapse of the infection and antibiotic resistance.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended unless specifically prescribed for a chronic infection. Prolonged use can lead to antibiotic resistance, disruption of normal gut flora, and an increased risk of superinfections such as oral thrush or C. difficile-associated diarrhea. Regular monitoring of kidney and liver function may be necessary if used for extended periods. Always consult your doctor before using this medicine for more than the prescribed duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For viral infections, rest, fluids, and over-the-counter remedies for fever and pain are appropriate.
Evidence: Well-establishedBased on culture and sensitivity results, a narrower-spectrum antibiotic may be more appropriate than this combination.
Evidence: Well-establishedMay help prevent antibiotic-associated diarrhea, but should be taken at least 2 hours apart from the antibiotic.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Antibiotics may reduce the effectiveness of live bacterial vaccines, such as the live typhoid vaccine. Complete the antibiotic course at least 3 days before receiving any live bacterial vaccine. Inactivated vaccines are not affected. Consult your doctor for specific timing recommendations.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription or a letter from your doctor, especially for international travel, as some countries have strict rules about antibiotics. Store it in a cool, dry place away from direct sunlight. If crossing time zones, adjust your dosing schedule gradually to maintain even intervals; consult your doctor for specific advice. Do not pack it in checked luggage; keep it in your carry-on. Check customs regulations for your destination regarding prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24 to 48 hours, but it may take a few days for full effect. Complete the full course as prescribed.
A: Yes, you can take it with or without food. Taking it with food may help reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: It is best to avoid alcohol while taking this medicine, as it can worsen side effects and may affect your recovery.
A: Both components are generally considered safe in pregnancy when clearly needed, but you should consult your doctor before taking any medicine during pregnancy.
A: Store at room temperature between 15°C and 30°C, away from light and moisture. Keep in the original container and out of reach of children.
🤔 Common Patient Concerns
🔄 Substitutes for azicox cf tablet
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Antibiotics can cure the common cold and flu.
Fact: This medicine is effective only against bacterial infections. Colds and flu are caused by viruses, so antibiotics will not help and may cause harm. - Myth: You can stop taking antibiotics once you feel better.
Fact: You must complete the full course as prescribed, even if symptoms improve, to ensure all bacteria are killed and to prevent resistance. - Myth: Antibiotics weaken your immune system.
Fact: Antibiotics do not weaken the immune system; they target bacteria. However, they can disrupt healthy gut bacteria, which may have temporary effects. - Myth: It is safe to take leftover antibiotics for a future infection.
Fact: Never take leftover antibiotics without a prescription. The infection may be different, and the dose may be incorrect, leading to treatment failure and resistance.
🔄 Alternative Options
Generic Alternatives
- Cefixime 250 mg + Azithromycin 200 mg tablet (various manufacturers)
Brand Alternatives
- Azicox CF Tablet