Axcef SB 1000mg/500mg Injection - Uses, Price, Side Effects
What is axcef sb 1000mg/500mg injection used for?
Axcef SB 1000mg/500mg Injection is a combination antibiotic containing Ceftriaxone (a cephalosporin) and Sulbactam (a beta-lactamase inhibitor). It is used to treat various bacterial infections such as respiratory tract infections, urinary tract infections, skin infections, and septicemia. Ceftriaxone kills bacteria by inhibiting cell wall synthesis, while Sulbactam prevents bacterial resistance by inhibiting beta-lactamase enzymes.
- Generic Name: Ceftriaxone + Sulbactam
- Manufacturer: Midas Biotek Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ axcef sb 1000mg/500mg injection Uses & Benefits
Lower respiratory tract infections, urinary tract infections, skin and soft tissue infections, intra-abdominal infections, septicemia, meningitis, bone and joint infections
Off-label uses: Gonorrhea, Lyme disease, pelvic inflammatory disease
๐ Drug Information
| Generic Name(s) | Ceftriaxone + Sulbactam |
| Brand Name | Accuzon Plus 1.5gm Injection |
| Manufacturer | Midas Biotek Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporin + Beta-lactamase inhibitor |
| Route of Administration | Intravenous (IV) or Intramuscular (IM) |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light; reconstituted solution stable for 24 hours at room temperature or 3 days refrigerated |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Ceftriaxone inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs); Sulbactam irreversibly inhibits beta-lactamases, protecting ceftriaxone from degradation.
Mechanism Steps
๐ก How to Take axcef sb 1000mg/500mg injection
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of axcef sb 1000mg/500mg injection
โ Common Side Effects
- Diarrhea
- Injection site reactions
- Rash
- Eosinophilia
๐จ Serious Side Effects
- Anaphylaxis
- Stevens-Johnson syndrome
- Clostridioides difficile colitis
- Hemolytic anemia
- Seizures
โ ๏ธ Rare Side Effects
- Pseudomembranous colitis
- Biliary sludge
- Interstitial nephritis
- Agranulocytosis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Alcohol | Moderate | Increased side effects like nausea and dizziness |
| Live vaccines | Moderate | Reduced vaccine efficacy |
๐จ Major Interactions
- Warfarin
- Alcohol (disulfiram-like reaction)
- Aminoglycosides (nephrotoxicity)
โก Moderate Interactions
- Probenecid
- Loop diuretics
- NSAIDs
โน๏ธ Minor Interactions
- Live vaccines
- BCG
๐ฝ๏ธ Food Interactions
None known
๐ท Alcohol Interaction
May cause disulfiram-like reaction (nausea, vomiting, headache)
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to cephalosporins or beta-lactam antibiotics; history of anaphylaxis to penicillins
๐ Monitoring Parameters
Renal function, hepatic function, CBC, signs of superinfection, bleeding tendencies
๐คฑ Lactation Safety
Excreted in breast milk in low amounts; generally considered compatible
๐ Overdose Management
Supportive care; hemodialysis may remove ceftriaxone but not sulbactam
โฐ Missed Dose
Administer as soon as remembered; if near next dose, skip missed dose; do not double dose