avucef 1000mg injection - Cefoperazone (1000mg) medicine

Avucef 1000mg Injection - Uses, Price, Side Effects

No reviews yet
🏭 Avunu Life Sciences 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

What is avucef 1000mg injection used for?

Avucef 1000mg Injection contains Cefoperazone, a cephalosporin antibiotic that kills bacteria by interfering with cell wall synthesis. It is used to treat various bacterial infections including respiratory tract, urinary tract, skin, and intra-abdominal infections.

  • Generic Name: Cefoperazone
  • Manufacturer: Avunu Life Sciences
  • Form: Allopathy
  • Pregnancy Category: Category B
  • Prescription Required: Yes
💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 avucef 1000mg injection Uses & Benefits

Treatment of respiratory tract infections, urinary tract infections, skin and soft tissue infections, septicemia, intra-abdominal infections, gynecological infections

Off-label uses: Bacterial meningitis, Lyme disease, Typhoid fever

📋 Drug Information

Generic Name(s)Cefoperazone
Brand NameAvucef 500mg Injection
ManufacturerAvunu Life Sciences
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI INFECTIVES
Action ClassCephalosporins: 3 generation
Route of AdministrationIntravenous (IV) or intramuscular (IM)
StorageStore at 20-25°C (68-77°F); protect from light
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionNot applicable (intravenous/intramuscular administration)
DistributionWidely distributed in body tissues and fluids including bile, sputum, pleural fluid, and peritoneal fluid
Protein Binding82-93%
MetabolismNot significantly metabolized
Half-Life1.7-2 hours
ExcretionPrimarily biliary (70-80%) and renal (20-30%)
Bioavailability100% (intravenous)
Onset of ActionRapid
Peak Plasma TimeImmediately after IV administration; 1-2 hours after IM administration
Duration of Action6-12 hours

How It Works

Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs)

Mechanism Steps

1Binds to penicillin-binding proteins (PBPs) on bacterial cell wall
2Inhibits transpeptidase activity
3Prevents cross-linking of peptidoglycan chains
4Weakens cell wall integrity
5Leads to bacterial cell lysis and death

💡 How to Take avucef 1000mg injection

Follow your doctor's prescription exactly.

Dosage Timeline

🌅 Morning ✅ ☀️ Afternoon ❌ 🌆 Evening ✅ 🌙 Night ❌

⚠️ Side Effects of avucef 1000mg injection

✅ Common Side Effects

Diarrhea
Nausea
Vomiting
Rash
Injection site reactions

🚨 Serious Side Effects

Pseudomembranous colitis
Anaphylaxis
Stevens-Johnson syndrome
Bleeding tendencies
Seizures

⚠️ Rare Side Effects

Hemolytic anemia
Agranulocytosis
Interstitial nephritis
Hepatitis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major Increased bleeding risk
Alcohol Moderate Disulfiram-like reaction
Probenecid Moderate Increased cefoperazone levels

🚨 Major Interactions

  • Alcohol
  • Warfarin
  • Heparin
  • Oral anticoagulants

⚡ Moderate Interactions

  • Aminoglycosides
  • Loop diuretics
  • Probenecid

🍷 Alcohol Interaction

Disulfiram-like reaction (flushing, headache, nausea, vomiting, tachycardia)

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to cefoperazone or other cephalosporins, severe penicillin allergy

🤱 Lactation Safety

Excreted in breast milk in small amounts; use with caution

💊 Overdose Management

Supportive care; hemodialysis may enhance elimination

⏰ Missed Dose

Administer as soon as remembered; do not double dose

🔄 Substitutes for avucef 1000mg injection

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

😊 Was this information helpful?

Browse Medicines A-Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Back to Medicines Directory