avidox-sp 100mg/10mg tablet - Uses, Price, Side Effects & Substitutes
What is avidox-sp 100mg/10mg tablet used for?
Avidox-SP 100mg/10mg Tablet (Doxycycline + Serratiopeptidase) is used to treat ANTI INFECTIVES. It contains Doxycycline (100mg) + Serratiopeptidase (10mg), which Doxycycline inhibits bacterial protein synthesis by binding to 30S ribosomal sub. Always consult your doctor before use. Take as prescribed.
- Generic Name: Doxycycline + Serratiopeptidase
- Manufacturer: Avalanche Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ avidox-sp 100mg/10mg tablet Uses & Benefits
Acne vulgaris, rosacea, respiratory tract infections, urinary tract infections, sexually transmitted infections, periodontitis, sinusitis, otitis media, and inflammatory conditions.
Off-label uses: Chronic prostatitis, epididymitis, malaria prophylaxis, scleroderma.
๐ Drug Information
| Generic Name(s) | Doxycycline + Serratiopeptidase |
| Brand Name | Avidox-SP 100mg/10mg Tablet |
| Manufacturer | Avalanche Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | ANTI INFECTIVES |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Doxycycline inhibits bacterial protein synthesis by binding to 30S ribosomal subunit; Serratiopeptidase reduces inflammation by breaking down fibrin and other proteins.
Mechanism Steps
๐ก How to Take avidox-sp 100mg/10mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of avidox-sp 100mg/10mg tablet
โ Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Photosensitivity
- Esophagitis
- Dyspepsia
๐จ Serious Side Effects
- Pseudomembranous colitis
- Stevens-Johnson syndrome
- Hepatotoxicity
- Intracranial hypertension
- Anaphylaxis
โ ๏ธ Rare Side Effects
- Blood dyscrasias
- Pancreatitis
- Pericarditis
- Systemic lupus erythematosus
- Thyroid discoloration
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased INR and bleeding risk |
| Oral contraceptives | Major | Reduced contraceptive efficacy |
| Penicillins | Major | Antagonistic effect |
| Antacids (Al, Ca, Mg) | Major | Reduced doxycycline absorption |
| Iron supplements | Major | Reduced doxycycline absorption |
| Bismuth subsalicylate | Major | Reduced doxycycline absorption |
| Methotrexate | Moderate | Increased methotrexate toxicity |
| Cyclosporine | Moderate | Increased nephrotoxicity risk |
| Digoxin | Moderate | Increased digoxin levels |
| Lithium | Moderate | Increased lithium levels |
| Barbiturates | Moderate | Reduced doxycycline half-life |
| Carbamazepine | Moderate | Reduced doxycycline half-life |
| Phenytoin | Moderate | Reduced doxycycline half-life |
| Antacids (NaHCO3) | Minor | Slight reduction in absorption |
| Zinc supplements | Minor | Reduced doxycycline absorption |
| Dairy products | Minor | Reduced doxycycline absorption |
๐จ Major Interactions
- Warfarin
- Oral contraceptives
- Penicillins
- Antacids containing aluminum, calcium, or magnesium
- Iron supplements
- Bismuth subsalicylate
โก Moderate Interactions
- Methotrexate
- Cyclosporine
- Digoxin
- Lithium
- Barbiturates
- Carbamazepine
- Phenytoin
โน๏ธ Minor Interactions
- Antacids containing sodium bicarbonate
- Zinc supplements
- Dairy products
๐ฝ๏ธ Food Interactions
Dairy products, calcium-fortified foods, and antacids reduce absorption; take on empty stomach.
๐ท Alcohol Interaction
Alcohol may reduce effectiveness and increase hepatotoxicity risk.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to tetracyclines or serratiopeptidase; pregnancy; lactation; children under 8 years (doxycycline); severe hepatic impairment.
๐ Monitoring Parameters
Liver function tests, renal function, blood counts, signs of superinfection.
๐คฑ Lactation Safety
Doxycycline is excreted in breast milk; avoid use or discontinue breastfeeding.
๐ Overdose Management
Gastric lavage, activated charcoal, supportive care; no specific antidote.
โฐ Missed Dose
Take as soon as remembered unless near next dose; do not double dose.