atzon s 500mg/500mg injection - Uses, Price, Side Effects & Substitutes
What is atzon s 500mg/500mg injection used for?
Acuzone S 1000mg/500mg Injection (Cefoperazone + Sulbactam) is used to treat ANTI INFECTIVES. It contains Cefoperazone (500mg) + Sulbactam (500mg), which Cefoperazone inhibits bacterial cell wall synthesis by binding to penicillin-bin. Always consult your doctor before use. Take as prescribed.
- Generic Name: Cefoperazone + Sulbactam
- Manufacturer: Aton Biotech
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ atzon s 500mg/500mg injection Uses & Benefits
Treatment of infections caused by susceptible organisms: respiratory tract infections, intra-abdominal infections, skin and soft tissue infections, septicemia, urinary tract infections, gynecological infections, and perioperative prophylaxis.
Off-label uses: Bone and joint infections, Meningitis (when other agents fail), Febrile neutropenia (in combination)
๐ Drug Information
| Generic Name(s) | Cefoperazone + Sulbactam |
| Brand Name | Acuzone S 1000mg/500mg Injection |
| Manufacturer | Aton Biotech |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporin + Beta-lactamase inhibitor |
| Route of Administration | Intravenous (IV) or intramuscular (IM) |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light; reconstituted solution stable for 24 hours at room temperature and 5 days under refrigeration. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Cefoperazone inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs); Sulbactam irreversibly inhibits beta-lactamases, protecting cefoperazone from degradation.
Mechanism Steps
๐ก How to Take atzon s 500mg/500mg injection
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of atzon s 500mg/500mg injection
โ Common Side Effects
- Diarrhea
- Nausea
- Vomiting
- Rash
- Injection site pain
- Phlebitis
- Elevated liver enzymes
๐จ Serious Side Effects
- Severe allergic reactions (anaphylaxis)
- Stevens-Johnson syndrome
- Clostridioides difficile-associated diarrhea
- Seizures
- Bleeding tendencies (hypoprothrombinemia)
โ ๏ธ Rare Side Effects
- Agranulocytosis
- Hemolytic anemia
- Interstitial nephritis
- Pseudomembranous colitis
- Serum sickness-like reactions
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Alcohol | Major | Disulfiram-like reaction |
| Warfarin | Major | Increased INR and bleeding risk |
| Heparin | Major | Increased bleeding risk |
| Methotrexate | Major | Increased methotrexate toxicity |
| Probenecid | Major | Decreased renal excretion of cefoperazone |
| Aminoglycosides | Moderate | Increased nephrotoxicity risk |
| Loop diuretics | Moderate | Increased nephrotoxicity risk |
| NSAIDs | Moderate | Increased bleeding risk |
| Oral contraceptives | Moderate | Reduced contraceptive efficacy |
| Antacids | Minor | Reduced absorption (oral forms) |
| Iron supplements | Minor | Reduced absorption (oral forms) |
| Zinc supplements | Minor | Reduced absorption (oral forms) |
๐จ Major Interactions
- Alcohol
- Warfarin
- Heparin
- Methotrexate
- Probenecid
โก Moderate Interactions
- Aminoglycosides
- Loop diuretics
- NSAIDs
- Oral contraceptives
โน๏ธ Minor Interactions
- Antacids
- Iron supplements
- Zinc supplements
๐ฝ๏ธ Food Interactions
No significant food interactions; avoid alcohol during treatment and for 72 hours after last dose.
๐ท Alcohol Interaction
Disulfiram-like reaction (flushing, headache, nausea, vomiting, tachycardia) can occur if alcohol is consumed within 72 hours of administration.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to cephalosporins, penicillins, or beta-lactamase inhibitors; severe renal impairment (CrCl <15 mL/min) without dose adjustment.
๐ Monitoring Parameters
Renal function, hepatic function, CBC with differential, prothrombin time (especially in patients at risk of bleeding), signs of superinfection.
๐คฑ Lactation Safety
Cefoperazone and sulbactam are excreted in breast milk in low concentrations; use with caution.
๐ Overdose Management
Supportive care; hemodialysis may enhance elimination; monitor for seizures and hypersensitivity reactions.
โฐ Missed Dose
Administer as soon as remembered; if near next dose, skip missed dose and resume regular schedule; do not double dose.