Ap Cef-Az Tablet - Uses, Price, Side Effects
What is ap cef-az tablet used for?
Ap Cef-Az Tablet is a combination antibiotic containing Cefixime (200mg) and Azithromycin (250mg). It is used to treat various bacterial infections such as respiratory tract infections, urinary tract infections, and skin infections. Cefixime works by inhibiting bacterial cell wall synthesis, while Azithromycin stops bacterial protein synthesis, together providing broad-spectrum coverage.
- Generic Name: Cefixime + Azithromycin
- Manufacturer: Assure Pharma
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ ap cef-az tablet Uses & Benefits
Respiratory tract infections, urinary tract infections, typhoid fever, gonorrhea, skin and soft tissue infections
Off-label uses: Lyme disease, pertussis, chancroid, granuloma inguinale
๐ Drug Information
| Generic Name(s) | Cefixime + Azithromycin |
| Brand Name | Azicef-LB Tablet |
| Manufacturer | Assure Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporin antibiotic + Macrolide antibiotic |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Cefixime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins; Azithromycin inhibits protein synthesis by binding to 50S ribosomal subunit
Mechanism Steps
๐ก How to Take ap cef-az tablet
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of ap cef-az tablet
โ Common Side Effects
- Diarrhea
- Nausea
- Vomiting
- Abdominal pain
- Headache
- Dizziness
- Rash
๐จ Serious Side Effects
- Pseudomembranous colitis
- Severe allergic reactions (anaphylaxis)
- Stevens-Johnson syndrome
- Hepatotoxicity
- QT prolongation
- Torsades de pointes
โ ๏ธ Rare Side Effects
- Interstitial nephritis
- Hemolytic anemia
- Thrombocytopenia
- Agranulocytosis
- Pancreatitis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Antacids | Moderate | Reduced absorption of Cefixime |
| Digoxin | Moderate | Increased digoxin levels |
๐จ Major Interactions
- Warfarin
- Disulfiram
- Methotrexate
- Ergot derivatives
- Pimozide
โก Moderate Interactions
- Oral contraceptives
- Antacids
- Digoxin
- Cyclosporine
- Theophylline
โน๏ธ Minor Interactions
- Vitamin K antagonists
- Probenecid
๐ฝ๏ธ Food Interactions
Cefixime: Food delays absorption; Azithromycin: Food decreases absorption (take on empty stomach)
๐ท Alcohol Interaction
Avoid alcohol; may increase risk of hepatotoxicity and disulfiram-like reaction
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to cephalosporins, macrolides, or any component; history of cholestatic jaundice/hepatic dysfunction with azithromycin
๐ Monitoring Parameters
Renal function, hepatic function, CBC, signs of superinfection, QT interval if risk factors
๐คฑ Lactation Safety
Cefixime: Excreted in breast milk in low amounts, generally considered safe; Azithromycin: Excreted
๐ Overdose Management
Supportive care; no specific antidote; consider gastric lavage if recent ingestion
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose; do not double dose