amzeclav 200mg/28.5mg syrup - Amoxycillin (200mg) + Clavulanic Acid (28.5mg) medicine

Moxikind-CV Dry Syrup: Complete Information

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🏭 Zeal Biotech Pvt td 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for approved indications.
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Difficulty breathing or swelling of face, lips, or throat
  • Severe or bloody diarrhoea
  • Yellowing of skin or eyes
  • Severe abdominal pain
  • Persistent high fever not improving after 48-72 hours
  • Signs of dehydration (decreased urine output, dry mouth, lethargy)
  • New rash or hives

If experiencing severe symptoms, call emergency services immediately.

What is amzeclav 200mg/28.5mg syrup used for?

This medicine is a pediatric antibiotic dry syrup containing Amoxycillin and Clavulanic Acid. It treats bacterial infections of the ear, nose, throat, chest, urinary tract, and skin. It works by killing bacteria and blocking their resistance mechanisms. It must be used only under a doctor's supervision.

  • Generic Name: Amoxycillin (200mg) + Clavulanic Acid (28.5mg)
  • Manufacturer: Zeal Biotech Pvt td
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 amzeclav 200mg/28.5mg syrup के बारे में (Hindi Summary)

उपयोग: यह दवा एक एंटीबायोटिक ड्राई सिरप है जिसमें अमोक्सिसिलिन और क्लैवुलैनिक एसिड होता है। इसका उपयोग बच्चों में कान, नाक, गले, छाती, मूत्र मार्ग, त्वचा और नरम ऊतकों के बैक्टीरियल संक्रमण के इलाज के लिए किया जाता है। यह बैक्टीरिया को मारकर और उनके प्रतिरोध तंत्र को रोककर काम करती है। यह दवा केवल डॉक्टर के निर्देशानुसार ही दी जानी चाहिए।

साइड इफेक्ट्स: आम दुष्प्रभावों में दस्त, जी मिचलाना, उल्टी, त्वचा पर दाने और मुँह या योनि में फंगल संक्रमण शामिल हैं। ये आमतौर पर हल्के होते हैं और अपने आप ठीक हो जाते हैं। गंभीर दुष्प्रभाव जैसे एलर्जी, लीवर की समस्या और गंभीर त्वचा प्रतिक्रियाएँ दुर्लभ हैं लेकिन तुरंत डॉक्टर से संपर्क करना आवश्यक है।

सुरक्षा सलाह: हर बार दवा देने से पहले बोतल को अच्छी तरह हिलाएँ। दवा के साथ दी गई मापने वाली चम्मच या सिरिंज का ही उपयोग करें। बच्चे के ठीक होने पर भी पूरा कोर्स पूरा करें। बच्चों की पहुँच से दूर रखें। यदि बच्चे को किडनी या लीवर की समस्या है या एलर्जी है तो डॉक्टर को बताएं।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 amzeclav 200mg/28.5mg syrup Uses & Benefits

[{"condition":"Acute otitis media","description":"This medicine is commonly prescribed for middle ear infections in children caused by bacteria such as Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis.","evidence":"Well-established"},{"condition":"Sinusitis","description":"Used to treat bacterial sinusitis when symptoms are severe or persistent, particularly when resistant organisms are suspected.","evidence":"Well-established"},{"condition":"Community-acquired pneumonia","description":"Effective against common respiratory pathogens in children, including Streptococcus pneumoniae and Haemophilus influenzae.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Used for uncomplicated urinary tract infections caused by susceptible bacteria such as Escherichia coli and Klebsiella species.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats infections like cellulitis, impetigo, and abscesses caused by Staphylococcus aureus and Streptococcus species.","evidence":"Well-established"},{"condition":"Dental infections","description":"Used for dental abscesses and pericoronitis caused by oral anaerobes and streptococci.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Lyme disease","description":"Sometimes used off-label for early Lyme disease in children who cannot take doxycycline, though evidence is limited.","evidence":"Limited"},{"condition":"Helicobacter pylori eradication","description":"Part of some regimens for H. pylori eradication in children, but not a first-line choice.","evidence":"Limited"}]

Primary treatment for: Bacterial infections

Also treats: Otitis media, Sinusitis, Pneumonia, Urinary tract infections, Skin infections

📋 Drug Information

Generic Name(s)Amoxycillin (200mg) + Clavulanic Acid (28.5mg)
Brand Nameamzeclav 200mg/28.5mg syrup
ManufacturerZeal Biotech Pvt td
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI INFECTIVES
Action Class
Route of AdministrationOral
StorageStore the dry powder at room temperature (15-30°C) in a dry place, away from direct sunlight. After reconstitution, store the syrup in the refrigerator (2-8°C) and use within 7 days. Do not freeze. Keep the bottle tightly closed.
Shelf Life24 months from the date of manufacture for the dry powder. After reconstitution, use within 7 days if refrigerated.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always prescribe the correct weight-based dose for children.
2
Advise parents to complete the full course even if symptoms improve.
3
Warn about the risk of diarrhoea and advise hydration.
4
Instruct parents to store the reconstituted syrup in the refrigerator and discard after 7 days.
5
Monitor for signs of allergic reactions, especially during the first dose.
6
Consider alternative antibiotics if the child has a penicillin allergy.
7
Educate parents about the importance of not sharing the medicine with other children.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Ear pain
This medicine is commonly prescribed for ear infections.
Likely Use
❌
Fever
This medicine is not a primary fever reducer; it treats the underlying bacterial infection.
Not Primary
✅
Cough
May be used for bacterial pneumonia or bronchitis.
Likely Use
✅
Sore throat
Used for bacterial pharyngitis or tonsillitis.
Likely Use
❌
Runny nose
Viral infections do not respond to antibiotics.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionAmoxycillin and Clavulanic Acid are well absorbed from the gastrointestinal tract after oral administration. Food does not significantly affect the absorption of Amoxycillin but may improve tolerance. Peak plasma concentrations are achieved within 1 to 2 hours.
DistributionBoth components distribute widely into body tissues and fluids, including middle ear fluid, sinus secretions, lungs, urine, and skin. Amoxycillin penetrates cerebrospinal fluid only when meninges are inflamed. Clavulanic Acid distribution is similar but less extensive.
Protein BindingAmoxycillin is approximately 18% bound to plasma proteins. Clavulanic Acid is about 25% bound.
MetabolismAmoxycillin is partially metabolized to inactive penicilloic acid. Clavulanic Acid is extensively metabolized in the liver to inactive metabolites.
Half-LifeThe elimination half-life of Amoxycillin is approximately 1 to 1.5 hours. Clavulanic Acid has a half-life of about 1 hour. Both are prolonged in renal impairment.
ExcretionAmoxycillin is primarily excreted unchanged in the urine by glomerular filtration and tubular secretion. Clavulanic Acid is excreted in urine and faeces.
BioavailabilityThe oral bioavailability of Amoxycillin is approximately 70% to 90%. Clavulanic Acid bioavailability is about 60% to 70%.
Onset of ActionBactericidal action begins within 1 to 2 hours after oral administration, but clinical improvement may take 24 to 48 hours.
Peak Plasma TimePeak plasma concentrations are reached 1 to 2 hours after oral administration.
Duration of ActionThe antibacterial effect lasts approximately 6 to 8 hours, requiring dosing every 8 to 12 hours.

How It Works

This medicine combines Amoxycillin, a bactericidal penicillin antibiotic, with Clavulanic Acid, a beta-lactamase inhibitor. Amoxycillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to bacterial lysis and death. Clavulanic Acid irreversibly inhibits beta-lactamase enzymes produced by certain bacteria, preventing them from destroying Amoxycillin. This extends the spectrum of Amoxycillin to include beta-lactamase-producing strains of Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus, and Escherichia coli.

Mechanism Steps

1
Clavulanic Acid inhibits beta-lactamase: Clavulanic Acid binds irreversibly to beta-lactamase enzymes, preventing them from hydrolyzing Amoxycillin.
2
Amoxycillin binds to penicillin-binding proteins: Amoxycillin attaches to PBPs on the bacterial cell wall, inhibiting the cross-linking of peptidoglycan.
3
Cell wall synthesis is blocked: Without proper cross-linking, the bacterial cell wall weakens and cannot maintain osmotic stability.
4
Bacterial lysis and death: The weakened cell wall leads to cell lysis and death of the bacteria, especially during active growth.

💡 How to Take amzeclav 200mg/28.5mg syrup

Strength: Dry syrup containing Amoxycillin 200 mg and Clavulanic Acid 28.5 mg per 5 mL after reconstitution.

1Shake the bottle well before each use.
2Measure the prescribed dose using the measuring cup or syringe provided.
3Give the medicine orally, with or without food.
4If giving with food, mix with a small amount of water, milk, or juice if desired.
5Ensure the child swallows the full dose.
6Wash the measuring device after each use.
7Close the bottle tightly and store as directed.

Dosage Information

Adult DosageThis medicine is primarily intended for pediatric use. For adults, the dosage form may not be suitable. Adult dosing of Amoxycillin-Clavulanic Acid is typically 500 mg/125 mg or 875 mg/125 mg tablets every 12 hours, but this dry syrup is not intended for adults. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosageThe dosage is based on the child's weight and the severity of infection. The usual dose is 20 to 45 mg/kg/day of the Amoxycillin component, divided every 12 hours, but dosing must be individualized by a pediatrician. Use the measuring device provided. Shake well before use. Do not exceed the prescribed dose.
Elderly DosageThis dry syrup is not intended for elderly patients. Elderly patients should use tablet formulations. Dose adjustment may be needed based on renal function. Consult a doctor.
Renal ImpairmentDose adjustment is required in patients with renal impairment. For creatinine clearance 10-30 mL/min, the dose should be reduced. For creatinine clearance less than 10 mL/min, the dose should be further reduced. Consult a doctor for specific dosing.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Monitor liver function. Dose adjustment may be needed. Consult a doctor.
Maximum Daily DoseThe maximum daily dose of the Amoxycillin component should not exceed 90 mg/kg/day in children, but must be individualized by a clinician.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Milk
Can be taken with milk
Does not affect absorption.
Grapefruit
No specific restriction
No known interaction.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Give the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of amzeclav 200mg/28.5mg syrup

✅ Common Side Effects

Diarrhoea (Common (5-10%))
Ensure adequate fluid intake. Consult doctor if diarrhoea is severe or persistent.
Nausea (Common (5-10%))
Administer with food to reduce nausea.
Vomiting (Common (5-10%))
Give with food and in smaller, more frequent doses if needed. Consult doctor if persistent.
Skin rash (Common (5-10%))
Stop the medicine and consult a doctor immediately if rash appears, as it may indicate allergy.
Oral thrush (Uncommon (1-5%))
Maintain good oral hygiene. Consult doctor for antifungal treatment if needed.

🚨 Serious Side Effects

Anaphylaxis (Rare (<0.1%))
Seek emergency medical help immediately if swelling of face, lips, throat, difficulty breathing, or severe dizziness occurs.
Hepatotoxicity (Rare (<0.1%))
Report yellowing of skin or eyes, dark urine, or severe abdominal pain to a doctor immediately.
Stevens-Johnson syndrome (Very rare (<0.01%))
Seek immediate medical attention if severe blistering, peeling skin, or mucosal lesions develop.
Clostridioides difficile-associated diarrhoea (Rare (<0.1%))
Consult a doctor if severe, persistent, or bloody diarrhoea occurs, even weeks after stopping the medicine.

⚠️ Rare Side Effects

Interstitial nephritis
Seek medical attention if decreased urine output, swelling, or fatigue occurs.
Seizures
Seek emergency care if seizures occur, especially in patients with renal impairment.
Blood dyscrasias
Report unusual bleeding, bruising, or persistent fever to a doctor.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Methotrexate Major
Allopurinol Moderate
Oral contraceptives Moderate
Probenecid Moderate
Mycophenolate mofetil Moderate
Antacids Minor
Iron supplements Minor

🚨 Major Interactions

  • Warfarin
  • Methotrexate
  • Allopurinol

⚡ Moderate Interactions

  • Oral contraceptives
  • Probenecid
  • Mycophenolate mofetil

🍷 Alcohol Interaction

Alcohol may worsen gastrointestinal side effects such as nausea and diarrhoea. It is advisable to avoid alcohol during treatment.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known allergy to penicillins or beta-lactam antibiotics","History of severe allergic reaction to any beta-lactam antibiotic","Previous history of cholestatic jaundice or hepatic dysfunction associated with this combination","Infectious mononucleosis (increased risk of rash)"]

⚠️ Warnings & Precautions

["Use with caution in patients with renal impairment; dose adjustment may be needed.","Use with caution in patients with hepatic impairment; monitor liver function.","May cause Clostridioides difficile-associated diarrhoea; if severe diarrhoea occurs, discontinue and consult a doctor.","May reduce efficacy of oral contraceptives; advise additional contraception.","Prolonged use may lead to overgrowth of non-susceptible organisms.","Not effective against viral infections.","Do not use in patients with a history of penicillin allergy."]

🤱 Lactation Safety

Amoxycillin and Clavulanic Acid are excreted in breast milk in small amounts. This medicine is generally considered compatible with breastfeeding, but monitor the infant for diarrhoea or thrush. Consult your doctor.

💊 Overdose Management

Overdose may cause gastrointestinal symptoms such as nausea, vomiting, and diarrhoea. In severe cases, fluid and electrolyte imbalance may occur. There is no specific antidote. Treatment is symptomatic and supportive. Maintain adequate hydration. In patients with renal impairment, hemodialysis may be considered to remove Amoxycillin from the bloodstream. Seek immediate medical attention if overdose is suspected.

⏰ Missed Dose

If a dose is missed, give it as soon as remembered. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Always shake the bottle well before measuring each dose. Use a proper measuring device provided with the medicine, not a household spoon. Complete the full course as prescribed, even if your child feels better. Do not save leftover medicine for future use. Keep out of reach of children. Do not use this medicine if the syrup has changed colour or contains particles. Inform your doctor if your child has kidney or liver problems, or a history of allergies. Do not give this medicine to anyone else, even if they have similar symptoms.

👴 Special Considerations for Elderly

💡 For Patients Above 65

This dry syrup is not intended for elderly patients. Elderly patients should use tablet formulations and may require dose adjustment based on renal function.

🤰 Pregnancy Planning (TTC)

This medicine is for pediatric use. For adults planning pregnancy, consult a doctor for appropriate antibiotic therapy.

🏥 Post-Surgery Considerations

This medicine may be prescribed to treat or prevent bacterial infections after surgery in children. Follow the doctor's instructions.

🦷 Dental Procedures

This medicine may be prescribed for dental infections or as prophylaxis before dental procedures in children with certain heart conditions. Consult a doctor.

💚 Lifestyle Tips for Better Results

🏃
Ensure your child gets plenty of rest.
🥗
Maintain good hydration.
😴
Provide a balanced diet to support recovery.
💧
Practice good hand hygiene to prevent spread of infection.
🧘
Keep follow-up appointments with the doctor.
🌞
Do not send the child to school until fever subsides and doctor advises.

🏋️ Exercise Considerations

No specific exercise restrictions, but allow rest during acute illness. Resume normal activities as tolerated.

🥗 Diet Recommendations

Offer plenty of fluids.
Include soft, easily digestible foods.
Avoid spicy or oily foods if stomach upset occurs.
Include probiotics like yogurt if diarrhoea develops.

💼 Impact on Daily Work & Life

This medicine is for children; it may cause drowsiness or dizziness in some cases. Children should avoid activities requiring alertness if affected.

🛑 When to Stop This Medicine

Stop the medicine only after completing the full prescribed course or as directed by the doctor. If serious side effects occur, stop and consult a doctor immediately.

📅 Long-Term Use Effects

Long-term use of this medicine may lead to bacterial resistance, superinfections, and rare liver or kidney problems. It is not intended for prolonged use. Regular monitoring of liver and kidney function may be needed if used for extended periods. Always consult a doctor before using for more than the prescribed duration.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Symptomatic treatment

For viral infections, rest, fluids, and fever reducers may be used.

Evidence: Well-established
Other antibiotics

If allergic to penicillin, alternative antibiotics like cephalosporins or macrolides may be prescribed.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

This medicine does not interact with vaccines. However, if the child is due for vaccination, consult the doctor. Antibiotics do not affect vaccine efficacy.

📦 Storage Guide

✅ DO

Store dry powder at room temperature (15-30°C)

❌ DON'T

Do not refrigerate the dry powder

✅ DO

After reconstitution, store in refrigerator (2-8°C)

❌ DON'T

Do not freeze the reconstituted syrup

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✅ DO

Discard reconstituted syrup after 7 days

❌ DON'T

Do not use beyond 7 days after reconstitution

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with the prescription label. For air travel, keep it in your carry-on luggage. If the syrup is already reconstituted, store it in a cool place or refrigerator if available. Carry a copy of the prescription to avoid customs issues. If traveling across time zones, adjust dosing times gradually. Consult your doctor for specific advice.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 3-year-old child with acute otitis media
The child had ear pain and fever. The doctor prescribed this medicine. The parents gave it with food and completed the 10-day course. The child improved within 3 days and had no side effects.
💡 Lesson: Completing the full course and giving with food improves outcomes and reduces stomach upset.
👤 A 5-year-old with pneumonia
The child was diagnosed with community-acquired pneumonia and prescribed this medicine. After 2 days, the fever subsided. The parents ensured proper storage and dosing. The child recovered fully.
💡 Lesson: Adherence to dosing schedule and proper storage are key to successful treatment.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Improvement is usually seen within 48 to 72 hours, but the full course must be completed.

Q: Can this medicine be given with food?

A: Yes, it can be given with or without food. Giving with food may reduce stomach upset.

Q: What if my child misses a dose?

A: Give the missed dose as soon as remembered, unless it is almost time for the next dose. Do not double dose.

Q: Are there any food restrictions?

A: No specific food restrictions, but avoid giving with antacids or iron supplements within 2 hours.

Q: Can this medicine be used for cold and flu?

A: No, it is not effective against viral infections like cold and flu.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can this medicine be given to my child with milk?
  • What if my child vomits after taking the medicine?
  • Can this medicine cause diarrhoea?
  • How long does it take to work?
  • Can I stop the medicine if my child feels better?
  • Is this medicine safe for newborns?

🔄 Substitutes for amzeclav 200mg/28.5mg syrup

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure viral infections like the common cold.
    Fact: This medicine is an antibiotic and is only effective against bacterial infections. It does not treat viral infections.
  • Myth: You can stop the medicine once your child feels better.
    Fact: You must complete the full prescribed course to prevent bacterial resistance and recurrence of infection.
  • Myth: This medicine can be given to anyone with a fever.
    Fact: This medicine is prescribed for specific bacterial infections. It should not be used for fever without a doctor's advice.

🔄 Alternative Options

Generic Alternatives

  • Amoxycillin + Clavulanic Acid dry syrup (generic)

Brand Alternatives

  • Moxikind-CV Dry Syrup

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Amoxycillin 200 mg + Clavulanic Acid 28.5 mg per 5 mL","route":"Oral","uses":"Broad-spectrum bacterial infections"},{"medicine":"Amoxycillin dry syrup","composition":"Amoxycillin 125 mg or 250 mg per 5 mL","route":"Oral","uses":"Bacterial infections (narrower spectrum)"},{"medicine":"Cefixime dry syrup","composition":"Cefixime 50 mg or 100 mg per 5 mL","route":"Oral","uses":"Bacterial infections (cephalosporin)"}]

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