amlosalt rm 5mg/5mg tablet - Uses, Price, Side Effects & Substitutes
What is amlosalt rm 5mg/5mg tablet used for?
Ampine RL 5 mg/2.5 mg Tablet (Amlodipine + Ramipril) is used to treat CARDIAC. It contains Amlodipine (5mg) + Ramipril (5mg), which Amlodipine inhibits calcium influx across cell membranes, causing vasodilation; . Always consult your doctor before use. Take as prescribed.
- Generic Name: Amlodipine + Ramipril
- Manufacturer: Cardiatic Care
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ amlosalt rm 5mg/5mg tablet Uses & Benefits
Hypertension, alone or in combination; not for initial therapy.
Off-label uses: Heart failure (amlodipine), diabetic nephropathy (ramipril), stroke prevention.
๐ Drug Information
| Generic Name(s) | Amlodipine + Ramipril |
| Brand Name | Ampine RL 5 mg/2.5 mg Tablet |
| Manufacturer | Cardiatic Care |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Antihypertensive combination (Calcium channel blocker + ACE inhibitor) |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Amlodipine inhibits calcium influx across cell membranes, causing vasodilation; Ramipril inhibits ACE, reducing angiotensin II and aldosterone, leading to vasodilation and decreased blood pressure.
Mechanism Steps
๐ก How to Take amlosalt rm 5mg/5mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of amlosalt rm 5mg/5mg tablet
โ Common Side Effects
- Edema
- Dizziness
- Fatigue
- Cough
- Headache
- Nausea
๐จ Serious Side Effects
- Angioedema
- Hyperkalemia
- Acute renal failure
- Hepatotoxicity
- Severe hypotension
โ ๏ธ Rare Side Effects
- Stevens-Johnson syndrome
- Pancreatitis
- Agranulocytosis
- Anaphylaxis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Lithium | Major | Increased lithium toxicity risk |
| Potassium-sparing diuretics | Major | Hyperkalemia risk |
| Aliskiren | Major | Increased risk of hypotension, hyperkalemia, renal impairment |
| CYP3A4 inhibitors | Major | Increased amlodipine levels |
| CYP3A4 inducers | Major | Decreased amlodipine efficacy |
| NSAIDs | Moderate | Reduced antihypertensive effect, increased renal risk |
| Antidiabetic agents | Moderate | Enhanced hypoglycemic effect |
| Digoxin | Moderate | Possible increased digoxin levels |
| Simvastatin | Moderate | Increased simvastatin levels (limit simvastatin to 20 mg) |
| Warfarin | Moderate | Possible increased INR |
| Antacids | Minor | Decreased absorption of ramipril |
| Cimetidine | Minor | Possible increased amlodipine levels |
| Grapefruit juice | Minor | Increased amlodipine levels |
๐จ Major Interactions
- Lithium
- Potassium-sparing diuretics
- Aliskiren
- CYP3A4 inhibitors (e.g., ketoconazole)
- CYP3A4 inducers (e.g., rifampin)
โก Moderate Interactions
- NSAIDs
- Antidiabetic agents
- Digoxin
- Simvastatin
- Warfarin
โน๏ธ Minor Interactions
- Antacids
- Cimetidine
- Grapefruit juice
๐ฝ๏ธ Food Interactions
Grapefruit juice may increase amlodipine levels; avoid high-potassium foods with ramipril.
๐ท Alcohol Interaction
May enhance hypotensive effect; avoid excessive alcohol.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, pregnancy, history of angioedema with ACE inhibitors, bilateral renal artery stenosis, severe hypotension, concomitant aliskiren in diabetes.
๐ Monitoring Parameters
Blood pressure, heart rate, serum potassium, renal function, liver function, signs of angioedema.
๐คฑ Lactation Safety
Not recommended; amlodipine and ramipril excreted in breast milk.
๐ Overdose Management
Symptomatic and supportive; monitor blood pressure, heart rate; consider activated charcoal, IV fluids, vasopressors.
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose; do not double.