amlonip 5mg tablet - S-Amlodipine (5mg) medicine

S-Amlodipine 5mg Tablet: Complete Guide to Uses, Dosage, and Safety

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🏭 Curelife Pharmaceuticals 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 20, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for hypertension and angina.
Reviewed by
SaathiMed Expert Panel | Sep 20, 2026

When to Call Your Doctor IMMEDIATELY

  • Severe chest pain or worsening angina
  • Fainting or severe dizziness
  • Swelling of face, lips, tongue, or throat
  • Difficulty breathing
  • Irregular or very fast heartbeat
  • Yellowing of skin or eyes
  • Severe abdominal pain

If experiencing severe symptoms, call emergency services immediately.

What is amlonip 5mg tablet used for?

This medicine is a prescription tablet containing S-Amlodipine 5 mg, used to treat high blood pressure and prevent angina. It works by relaxing blood vessels, making it easier for the heart to pump blood. It is taken once daily, with or without food, but grapefruit juice should be avoided.

  • Generic Name: S-Amlodipine (5mg)
  • Manufacturer: Curelife Pharmaceuticals
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 amlonip 5mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा उच्च रक्तचाप (हाई ब्लड प्रेशर) को नियंत्रित करने और एंजाइना (सीने में दर्द) को रोकने के लिए इस्तेमाल की जाती है। यह रक्त वाहिकाओं को आराम देकर उन्हें चौड़ा करती है, जिससे रक्त का प्रवाह आसान हो जाता है और हृदय पर दबाव कम होता है। इसे आमतौर पर दिन में एक बार लिया जाता है, भोजन के साथ या बिना। इस दवा को डॉक्टर के परामर्श के बिना बंद न करें।

साइड इफेक्ट्स: आम दुष्प्रभावों में टखनों या पैरों में सूजन, चक्कर आना, सिरदर्द, चेहरे पर गर्मी लगना और थकान शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि आपको सीने में दर्द, सांस लेने में कठिनाई, या चेहरे, होंठ या गले में सूजन हो, तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे रोज एक ही समय पर लें। अंगूर का जूस न पिएं क्योंकि इससे दवा का असर बढ़ सकता है। शराब से बचें क्योंकि इससे चक्कर आ सकते हैं। गाड़ी चलाते समय सावधानी बरतें जब तक आपको पता न चल जाए कि यह दवा आप पर कैसा असर करती है। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। दवा को कमरे के तापमान पर सूखी जगह पर रखें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 amlonip 5mg tablet Uses & Benefits

[{"condition":"Hypertension","description":"This medicine is used to lower high blood pressure by relaxing blood vessels, which reduces the risk of heart attack, stroke, and kidney problems.","evidence":"Well-established"},{"condition":"Chronic stable angina","description":"It helps to prevent chest pain by improving blood flow to the heart and reducing the heart's workload.","evidence":"Well-established"},{"condition":"Vasospastic angina (Prinzmetal's angina)","description":"This medicine can help prevent coronary artery spasms that cause chest pain at rest.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Raynaud's phenomenon","description":"Sometimes prescribed off-label to improve blood flow to fingers and toes in people with this condition.","evidence":"Limited"},{"condition":"Pulmonary arterial hypertension","description":"Occasionally used off-label, but not a first-line treatment.","evidence":"Limited"}]

Primary treatment for: Hypertension

Also treats: Angina, Coronary artery disease

📋 Drug Information

Generic Name(s)S-Amlodipine (5mg)
Brand Nameamlonip 5mg tablet
ManufacturerCurelife Pharmaceuticals
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action ClassCalcium channel blockers- Dihydropyridines (DHP)
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine at the same time each day to maintain consistent blood levels.
2
Monitor your blood pressure regularly and keep a record to share with your doctor.
3
Avoid grapefruit juice as it can increase the risk of side effects.
4
Do not stop this medicine suddenly without consulting your doctor, as it can worsen angina or blood pressure.
5
If you experience swelling in your ankles, elevate your legs and inform your doctor.
6
Limit alcohol intake as it can increase dizziness and low blood pressure.
7
Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

High blood pressure
This medicine is commonly prescribed for this.
Likely Use
Chest pain (angina)
This medicine helps prevent angina attacks.
Likely Use
Fever
This medicine is not a fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionS-Amlodipine is well absorbed after oral administration, with peak blood levels reached within 6 to 12 hours. The absolute bioavailability is approximately 64% to 80%.
DistributionIt is widely distributed throughout the body. The volume of distribution is approximately 21 L/kg. It is highly bound to plasma proteins.
Protein BindingApproximately 93% bound to plasma proteins.
MetabolismS-Amlodipine is extensively metabolized in the liver, primarily by the enzyme CYP3A4. It is converted into inactive metabolites.
Half-LifeThe elimination half-life is approximately 30 to 50 hours, which allows for once-daily dosing.
ExcretionIt is excreted mainly in the urine as inactive metabolites, with about 10% excreted unchanged in the urine.
BioavailabilityThe absolute bioavailability is approximately 64% to 80%.
Onset of ActionThe onset of blood pressure lowering effect is gradual, typically within 24 to 48 hours after starting treatment, but full effect may take 1 to 2 weeks.
Peak Plasma TimePeak plasma concentrations are reached 6 to 12 hours after oral administration.
Duration of ActionThe blood pressure lowering effect lasts for about 24 hours, allowing once-daily dosing.

How It Works

S-Amlodipine is a dihydropyridine calcium channel blocker. It works by blocking the entry of calcium ions into the smooth muscle cells of the blood vessels and the heart. This action causes the blood vessels to relax and widen, which lowers blood pressure and improves blood flow. It also reduces the force of heart contractions and slows the heart rate slightly, which decreases the heart's oxygen demand and helps prevent angina.

Mechanism Steps

1
Calcium channel blockade: S-Amlodipine binds to L-type calcium channels on the surface of smooth muscle cells in blood vessels and the heart.
2
Reduced calcium influx: By blocking these channels, it reduces the amount of calcium that enters the cells.
3
Vasodilation: Lower calcium levels cause the smooth muscle cells to relax, leading to widening of blood vessels.
4
Decreased blood pressure: The widening of blood vessels reduces peripheral resistance, which lowers blood pressure.
5
Reduced cardiac workload: The heart works less hard to pump blood, which reduces its oxygen demand and helps prevent angina.

💡 How to Take amlonip 5mg tablet

Strength: Tablet, 5 mg

1Take this medicine at the same time each day, with or without food.
2Swallow the tablet whole with a glass of water. Do not crush or chew.
3If it upsets your stomach, take it with a meal.
4Avoid drinking grapefruit juice while taking this medicine.
5Do not stop taking this medicine without consulting your doctor.

Dosage Information

Adult DosageThe usual starting dose for adults is 5 mg once daily. Your doctor may increase the dose to a maximum of 10 mg once daily if needed. The dose must be individualized by a qualified clinician based on your condition, age, and other medications you are taking. Do not change the dose without consulting your doctor.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be started on a lower dose, usually 2.5 mg once daily, and increased gradually as needed. Close monitoring is recommended.
Renal ImpairmentNo dose adjustment is usually needed for mild to moderate kidney impairment. In severe kidney disease, use with caution and monitor closely.
Hepatic ImpairmentIn patients with liver impairment, the starting dose should be reduced, usually 2.5 mg once daily, and titrated slowly. Close monitoring is required.
Maximum Daily Dose10 mg per day.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With or without food
Take at the same time each day
Food does not significantly affect absorption.
Grapefruit juice
Avoid
Can increase drug levels and side effects.

⏰ What to Do If You Miss a Dose

📌 Less than 12 hours have passed since the missed dose
→ Take the missed dose as soon as you remember.
💡 Continue with your regular schedule.
📌 More than 12 hours have passed since the missed dose
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of amlonip 5mg tablet

✅ Common Side Effects

Ankle swelling (edema) (Common (up to 10%))
Elevate your legs when sitting and avoid standing for long periods. If swelling is bothersome or persists, consult your doctor.
Dizziness (Common (5-10%))
Get up slowly from sitting or lying down. Avoid driving if you feel dizzy. If dizziness is severe or persistent, contact your doctor.
Headache (Common (5-10%))
Usually resolves on its own. Rest and stay hydrated. If headache is severe or persistent, consult your doctor.
Flushing (Common (5-10%))
This is usually temporary. If it bothers you, talk to your doctor.
Fatigue (Common (5-10%))
Ensure adequate rest. If fatigue interferes with daily activities, consult your doctor.

🚨 Serious Side Effects

Severe hypotension (very low blood pressure) (Rare (<0.1%))
Seek immediate medical attention if you experience fainting, severe dizziness, or confusion.
Worsening angina or heart attack (Rare (<0.1%))
If you experience new or worsening chest pain, especially after starting or increasing the dose, seek emergency medical help immediately.
Severe allergic reaction (anaphylaxis) (Very rare (<0.01%))
Call emergency services if you have swelling of the face, lips, tongue, or throat, difficulty breathing, or a severe rash.
Liver damage (Very rare (<0.01%))
Report yellowing of the skin or eyes, dark urine, or severe abdominal pain to your doctor immediately.

⚠️ Rare Side Effects

Gum hyperplasia
Maintain good oral hygiene and see your dentist regularly. Consult your doctor if gums become swollen or bleed.
Photosensitivity
Use sunscreen and protective clothing when outdoors. Consult your doctor if a rash develops.
Thrombocytopenia
Report unusual bruising or bleeding to your doctor immediately.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Ketoconazole Major
Rifampicin Major
Simvastatin Major
Metoprolol Moderate
Hydrochlorothiazide Moderate
Lisinopril Moderate
Antacids Minor
Grapefruit juice Minor

🚨 Major Interactions

  • CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir)
  • CYP3A4 inducers (e.g., rifampicin, carbamazepine, St. John's wort)
  • Simvastatin

⚡ Moderate Interactions

  • Beta-blockers (e.g., metoprolol, atenolol)
  • Diuretics (e.g., hydrochlorothiazide, furosemide)
  • ACE inhibitors (e.g., lisinopril, ramipril)

🍷 Alcohol Interaction

Alcohol may increase the blood pressure lowering effect of this medicine and can cause dizziness, drowsiness, or fainting. It is best to limit or avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Allergy to amlodipine or other dihydropyridine calcium channel blockers","Severe hypotension (very low blood pressure)","Cardiogenic shock","Severe aortic stenosis","Unstable angina (unless under close medical supervision)"]

⚠️ Warnings & Precautions

["May cause worsening of angina or heart attack when starting or increasing the dose. Report any new or worsening chest pain immediately.","Use with caution in patients with liver disease. Dose adjustment may be needed.","May cause dizziness or drowsiness. Avoid driving or operating machinery until you know how it affects you.","Avoid grapefruit juice while taking this medicine.","Do not stop taking this medicine suddenly without consulting your doctor.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Elderly patients may be more sensitive to the effects of this medicine."]

🤱 Lactation Safety

S-Amlodipine is excreted in human breast milk. Breastfeeding is not recommended while taking this medicine unless advised by your doctor.

💊 Overdose Management

Overdose can cause severe low blood pressure, dizziness, fainting, and rapid heartbeat. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and may include intravenous fluids and medications to raise blood pressure.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without consulting your doctor first, as stopping suddenly can worsen your condition. This medicine can be taken with or without food, but taking it at the same time each day helps you remember. Avoid drinking grapefruit juice while on this medicine, as it can increase the amount of medicine in your blood and cause side effects. Alcohol may increase dizziness, so limit or avoid alcohol. This medicine may cause dizziness or drowsiness, especially when you first start taking it. Do not drive or operate heavy machinery until you know how it affects you. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Keep all your medical appointments and get your blood pressure checked regularly. Store this medicine at room temperature, away from moisture and heat. Keep it out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the blood pressure lowering effects and may experience more dizziness. A lower starting dose is often recommended, and close monitoring is advised.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor before conceiving. This medicine may not be suitable during pregnancy, and your treatment may need to be changed.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine. It may need to be temporarily stopped before surgery, as advised by your doctor.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine. It may cause gum hyperplasia in rare cases, so maintain good oral hygiene and regular dental check-ups.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce strain on your heart.
🥗
Follow a low-salt diet to help control blood pressure.
😴
Engage in regular physical activity like walking or swimming, as advised by your doctor.
💧
Avoid smoking and limit alcohol consumption.
🧘
Manage stress through relaxation techniques like deep breathing or meditation.
🌞
Get adequate sleep and maintain a regular sleep schedule.

🏋️ Exercise Considerations

Regular exercise is beneficial, but avoid sudden strenuous activity if you have angina. Warm up and cool down gradually. If you experience chest pain, dizziness, or shortness of breath during exercise, stop and seek medical advice.

🥗 Diet Recommendations

Reduce salt intake to help lower blood pressure.
Include potassium-rich foods like bananas, oranges, and spinach, unless advised otherwise.
Limit saturated fats and processed foods.
Avoid grapefruit and grapefruit juice.
Stay well hydrated.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness, especially when you first start taking it. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their normal daily activities with caution.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience serious side effects or your doctor decides to change your treatment, they will guide you on how to stop safely.

📅 Long-Term Use Effects

Long-term use of this medicine is generally safe and effective for controlling blood pressure and angina. Regular monitoring of blood pressure, heart rate, and signs of swelling is recommended. In some patients, long-term use may cause mild gum hyperplasia or ankle swelling. Periodic blood tests may be advised to monitor liver and kidney function. Do not stop the medicine without medical advice.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Lifestyle modifications

Diet, exercise, and stress reduction can help control blood pressure and complement medicine.

Evidence: Well-established
Other antihypertensive classes

ACE inhibitors, ARBs, or diuretics may be alternatives if this medicine is not suitable.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are known. Continue routine vaccinations as advised by your doctor.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight and moisture

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If traveling across time zones, consult your doctor about adjusting the timing of your dose. Check local customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 55-year-old man with a history of high blood pressure and angina
He was prescribed this medicine 5 mg once daily. After two weeks, his blood pressure stabilized and he had fewer angina attacks. He initially experienced mild ankle swelling, which improved when he elevated his legs and reduced his salt intake.
💡 Lesson: Regular use and lifestyle modifications can effectively control blood pressure and angina. Mild side effects often improve with simple measures.
👤 A 62-year-old woman with hypertension and diabetes
She started this medicine and noticed dizziness when standing up quickly. Her doctor advised her to get up slowly and to monitor her blood pressure. After a few days, the dizziness subsided, and her blood pressure was well controlled.
💡 Lesson: Dizziness is common when starting this medicine but usually improves. Simple precautions like rising slowly can help.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine starts lowering blood pressure within 24 to 48 hours, but the full effect may take 1 to 2 weeks.

Q: Can I take this medicine with food?

A: Yes, you can take it with or without food. However, avoid grapefruit juice.

Q: What should I do if I miss a dose?

A: If you remember within 12 hours, take it. If more than 12 hours have passed, skip it and continue with your regular schedule. Do not double dose.

Q: Is this medicine safe during pregnancy?

A: Consult your doctor. It is not recommended unless clearly needed.

Q: Can I stop taking this medicine if my blood pressure is normal?

A: No, do not stop without consulting your doctor. Stopping suddenly can cause a dangerous rise in blood pressure.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for amlonip 5mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure high blood pressure permanently.
    Fact: This medicine controls high blood pressure but does not cure it. You need to take it regularly as prescribed.
  • Myth: You can stop taking this medicine once your blood pressure is normal.
    Fact: Stopping suddenly can cause a dangerous rise in blood pressure or worsening of angina. Always consult your doctor before stopping.
  • Myth: This medicine causes kidney damage.
    Fact: This medicine is generally safe for kidneys and is often used to protect kidney function in people with high blood pressure and diabetes.

🔄 Alternative Options

Generic Alternatives

  • S-Amlodipine 5 mg tablet

Brand Alternatives

  • Amlovas-S 5mg Tablet
  • S-Amlodipine 5mg Tablet
  • Amlopres-S 5mg Tablet
  • Stamlo-S 5mg Tablet

📊 Comparison with Similar Medicines

[{"medicine":"S-Amlodipine 5mg","class":"Calcium channel blocker","usual_dose":"5 mg once daily","common_side_effects":"Ankle swelling, dizziness, headache"},{"medicine":"Amlodipine 5mg","class":"Calcium channel blocker","usual_dose":"5 mg once daily","common_side_effects":"Ankle swelling, dizziness, headache"},{"medicine":"Telmisartan 40mg","class":"Angiotensin receptor blocker","usual_dose":"40 mg once daily","common_side_effects":"Dizziness, back pain, diarrhea"}]

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