Durataz 1000 mg/125 mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of face, lips, or throat
- Severe rash or blistering of skin
- Seizures or confusion
- Severe or bloody diarrhea
- Decreased urine output or swelling in legs
- Yellowing of eyes or skin
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is amditaz 1000mg/125mg injection used for?
This medicine is a combination antibiotic containing piperacillin and tazobactam, used to treat serious bacterial infections. It is given intravenously in a hospital setting. It works by killing bacteria and preventing their growth.
- Generic Name: Piperacillin + Tazobactam
- Manufacturer: MRG Biotech Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 amditaz 1000mg/125mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा पाइपरासिलिन और टैज़ोबैक्टम का संयोजन है, जिसका उपयोग गंभीर जीवाणु संक्रमणों के इलाज के लिए किया जाता है। यह अस्पताल में नस के माध्यम से दी जाती है। यह निमोनिया, मूत्र पथ के संक्रमण, पेट के संक्रमण, त्वचा के संक्रमण और स्त्री रोग संबंधी संक्रमणों के इलाज में प्रभावी है। यह दवा केवल डॉक्टर के निर्देश पर ही दी जानी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में दस्त, मतली, उल्टी, सिरदर्द, चकत्ते और इंजेक्शन स्थल पर दर्द शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी, दौरे, और रक्त विकार हो सकते हैं। किसी भी असामान्य लक्षण को तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल अस्पताल में डॉक्टर या नर्स द्वारा ही दी जानी चाहिए। इसे स्वयं न लें। अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों और दवाओं के बारे में बताएं। उपचार का पूरा कोर्स पूरा करें। एलर्जी के लक्षण दिखने पर तुरंत डॉक्टर को सूचित करें।
💊 amditaz 1000mg/125mg injection Uses & Benefits
[{"condition":"Hospital-acquired pneumonia","description":"Used to treat pneumonia acquired during hospital stay, caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Complicated urinary tract infections","description":"Effective against severe UTIs including pyelonephritis.","evidence":"Well-established"},{"condition":"Complicated intra-abdominal infections","description":"Used for infections like peritonitis and abscesses.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats severe cellulitis, abscesses, and diabetic foot infections.","evidence":"Well-established"},{"condition":"Gynecological infections","description":"Used for pelvic inflammatory disease and postpartum infections.","evidence":"Well-established"},{"condition":"Febrile neutropenia","description":"Empiric therapy for fever in neutropenic patients.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Bacterial meningitis","description":"Sometimes used when other antibiotics are not suitable, but not first-line.","evidence":"Limited"},{"condition":"Prophylaxis in surgery","description":"Occasionally used for surgical prophylaxis in certain procedures.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Pneumonia, Urinary tract infections, Intra-abdominal infections, Skin infections, Gynecological infections, Febrile neutropenia
📋 Drug Information
| Generic Name(s) | Piperacillin + Tazobactam |
| Brand Name | Ahentaz 4.5 Injection |
| Manufacturer | MRG Biotech Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Penicillin antibiotic with beta-lactamase inhibitor |
| Route of Administration | Intravenous (IV) infusion over 30 minutes. It can also be administered as an intramuscular injection in some cases, but IV is preferred |
| Storage | Store the unreconstituted vials at room temperature (20-25°C). After reconstitution, the solution should be used immediately. If not used immediately, store in refrigerator (2-8°C) for up to 24 hours. Do not freeze. |
| Shelf Life | 24 months from the date of manufacture for the unreconstituted vial. After reconstitution, use within 24 hours if refrigerated. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients. Piperacillin is a semisynthetic penicillin antibiotic that inhibits bacterial cell wall synthesis by binding to specific penicillin-binding proteins (PBPs) inside the bacterial cell wall. This binding interferes with the cross-linking of peptidoglycan chains, which is essential for cell wall strength and rigidity. As a result, the bacterial cell wall weakens, leading to cell lysis and death, especially in actively dividing bacteria. Tazobactam is a beta-lactamase inhibitor that works by irreversibly binding to and inactivating certain beta-lactamase enzymes produced by bacteria. These enzymes would otherwise hydrolyze and destroy piperacillin. By inhibiting these enzymes, tazobactam extends the spectrum of piperacillin to include many beta-lactamase-producing bacteria that would otherwise be resistant.
Mechanism Steps
💡 How to Take amditaz 1000mg/125mg injection
Strength: Injection: 1000 mg piperacillin + 125 mg tazobactam per vial. Also available in other strengths like 2 g/0.25 g, 3 g/0.375 g, and 4 g/0.5 g.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 3.375 g (3 g piperacillin + 0.375 g tazobactam) administered intravenously every 6 hours. For serious infections, the dose may be increased to 4.5 g every 6 to 8 hours. The duration of therapy depends on the type and severity of infection, typically 7 to 14 days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. For children 2 months and older, dosing is typically weight-based and determined by a pediatric infectious disease specialist. |
| Elderly Dosage | Elderly patients may have decreased renal function, so dose adjustment may be necessary based on creatinine clearance. Monitor renal function closely. No specific dose adjustment other than renal function-based is generally required. |
| Renal Impairment | Dose adjustment is required in patients with renal impairment. For creatinine clearance (CrCl) 20-40 mL/min, the dose is usually 2.25 g every 6 hours. For CrCl less than 20 mL/min, the dose is 2.25 g every 8 hours. For patients on hemodialysis, the dose is 2.25 g every 12 hours, with an additional dose after each dialysis session. Always consult a clinician for precise dosing. |
| Hepatic Impairment | No specific dose adjustment is recommended for hepatic impairment alone. However, monitor liver function tests periodically. Use with caution in patients with severe liver disease. |
| Maximum Daily Dose | The maximum recommended daily dose is 18 g of piperacillin component (e.g., 4.5 g every 6 hours). Doses above this are not recommended. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of amditaz 1000mg/125mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| Gentamicin | Major | |
| Probenecid | Moderate | |
| Vecuronium | Moderate | |
| Oral contraceptives | Moderate | |
| Furosemide | Minor |
🚨 Major Interactions
- Warfarin
- Methotrexate
- Probenecid
- Aminoglycosides (e.g., gentamicin)
⚡ Moderate Interactions
- Vecuronium
- Oral contraceptives
🍷 Alcohol Interaction
Alcohol should be avoided during treatment with this medicine as it may worsen side effects such as nausea, dizziness, and may increase the risk of liver toxicity. It is best to abstain from alcohol until the course is completed and you have recovered.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to piperacillin, tazobactam, or other beta-lactam antibiotics (penicillins, cephalosporins)","History of severe allergic reaction to any beta-lactam antibiotic","Concurrent use with live vaccines (may reduce efficacy)"]
⚠️ Warnings & Precautions
["Serious allergic reactions can occur. Ask about previous hypersensitivity to penicillins before administration.","Clostridioides difficile-associated diarrhea may occur. Report persistent diarrhea.","Seizures may occur, especially in patients with renal impairment. Adjust dose in renal failure.","Hematological effects: monitor blood counts; may cause bleeding disorders.","Use with caution in patients with renal impairment; dose adjustment required.","May cause false-positive results in certain urine glucose tests.","Prolonged use may lead to superinfection with resistant organisms."]
🤱 Lactation Safety
Piperacillin and tazobactam are excreted in human milk in low amounts. Caution should be exercised when administered to a nursing woman. Consult your doctor to weigh benefits and risks.
💊 Overdose Management
Overdose with this medicine may cause nausea, vomiting, diarrhea, and seizures. There is no specific antidote. Treatment is supportive and symptomatic. In case of overdose, discontinue the drug and monitor vital signs. Hemodialysis may be considered to remove piperacillin and tazobactam from the bloodstream in severe cases. Contact a poison control center or emergency department immediately.
⏰ Missed Dose
Since this medicine is administered by a healthcare professional, missed doses are unlikely. If a dose is missed, it should be given as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose to catch up. Inform your nurse or doctor if you think a dose was missed.
Additional Safety Advice
This medicine must be administered only by a healthcare professional in a hospital or clinic setting. Do not attempt to self-administer. Inform your doctor about all your medical conditions, especially kidney disease, bleeding disorders, or allergies to antibiotics. Tell your doctor about all other medicines you are taking, including over-the-counter drugs and herbal supplements. Complete the full course of treatment as prescribed, even if you feel better, to prevent recurrence and resistance. Report any signs of allergic reaction, such as rash, itching, swelling, or difficulty breathing, immediately. Avoid alcohol during treatment as it may worsen side effects. Maintain good hydration unless otherwise instructed. Your doctor may monitor your kidney function, liver function, and blood counts during treatment.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have decreased renal function, so dose adjustment is often necessary. They may also be more susceptible to side effects like seizures and kidney toxicity. Close monitoring is recommended.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before starting this medicine. It is classified as Pregnancy Category B, meaning it should be used only if clearly needed. Discuss the risks and benefits with your healthcare provider.
🏥 Post-Surgery Considerations
This medicine is often used to treat or prevent infections after surgery. It is administered intravenously in the hospital. Follow your surgeon's instructions regarding wound care and follow-up.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine. It may interact with other medications used during dental procedures. Your dentist may need to coordinate with your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise during treatment as your body is fighting an infection. Light activity like walking is fine if you feel up to it. Listen to your body and rest when needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital setting, so you will likely need to take time off work during treatment. You may experience fatigue, dizziness, or nausea, which can affect your ability to drive or operate machinery. It is best to rest and avoid driving until you feel fully recovered.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Complete the full course as prescribed, even if you feel better. Stopping early can lead to recurrence of infection and antibiotic resistance. If you experience serious side effects, your doctor may decide to stop the medicine and switch to an alternative.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance, superinfections, and alterations in gut flora. Prolonged use may also increase the risk of kidney or liver toxicity. Regular monitoring of renal and hepatic function is recommended during extended therapy. It is important to use this medicine only for the prescribed duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the infection and culture results, other antibiotics like cephalosporins, carbapenems, or fluoroquinolones may be used.
Evidence: Well-establishedRest, hydration, and fever control can complement antibiotic therapy.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the efficacy of live vaccines. Avoid live vaccines during treatment. Inactivated vaccines are generally safe but may have reduced response. Consult your doctor for vaccination timing.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not use if solution is discolored or contains particles
✈️ Traveling with This Medicine
This medicine is administered in a hospital setting, so travel is not applicable during treatment. If you are prescribed this medicine and need to travel, ensure you carry the original prescription and medical documents. Store the vials at room temperature and protect from light. If reconstituted, use within 24 hours if refrigerated. Check with airlines for carrying injectable medicines. Always inform your healthcare provider before travel.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 30 minutes to 1 hour after intravenous administration. You may start feeling better within 48 to 72 hours, but it is important to complete the full course.
A: No, this medicine must be administered by a healthcare professional in a hospital or clinic setting.
A: Report any side effects to your doctor immediately. Mild side effects like nausea or diarrhea may resolve on their own, but serious effects require medical attention.
🤔 Common Patient Concerns
🔄 Substitutes for amditaz 1000mg/125mg injection
View AllAlternative brands with exact same active ingredient:
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cidal 1000mg/125mg injectionNeon Laboratories Ltd ₹67.50 83% CHEAPER
-
blucillin tazo 1000 mg/125 mg injectionBlue Cross Laboratories Ltd ₹68.25 82.9% CHEAPER
-
dazopip np 1000mg/125mg injectionDr. D Pharma ₹80.63 79.7% CHEAPER
-
Sanotaz 1000mg/125mg InjectionArvincare Pharma ₹80.63 79.7% CHEAPER
-
lazocin 1.125gm injectionAllenge India ₹80.72 79.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken orally.
Fact: This medicine is only available as an intravenous injection and must be given by a healthcare professional. - Myth: This medicine can cure viral infections like the flu.
Fact: This medicine is an antibiotic and is only effective against bacterial infections, not viruses. - Myth: You can stop this medicine once you feel better.
Fact: You must complete the full course as prescribed to prevent recurrence and antibiotic resistance.
🔄 Alternative Options
Generic Alternatives
- Piperacillin and Tazobactam injection (generic versions available)
Brand Alternatives
- Durataz 1000 mg/125 mg injection