Alkacitral Liquid: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in urine or stool
- Severe abdominal pain or cramping
- Chest pain or difficulty breathing
- Severe headache with confusion or visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output or inability to urinate
- Irregular heartbeat or palpitations
- Muscle twitching or seizures
If experiencing severe symptoms, call emergency services immediately.
What is alkadin 1.25gm syrup used for?
This medicine is an oral liquid that contains disodium hydrogen citrate, a urinary alkalinizer. It is used to relieve burning during urinary tract infections, prevent and dissolve certain kidney stones, and treat distal renal tubular acidosis. It works by making the urine less acidic.
- Generic Name: Disodium Hydrogen Citrate
- Manufacturer: Edinburgh Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 alkadin 1.25gm syrup के बारे में (Hindi Summary)
उपयोग: यह दवा मुख्य रूप से मूत्र मार्ग के संक्रमण में जलन और दर्द को कम करने के लिए दी जाती है। यह पेशाब को कम अम्लीय बनाती है, जिससे बैक्टीरिया का बढ़ना कम होता है और जलन में आराम मिलता है। इसके अलावा, यह गुर्दे की पथरी (यूरिक एसिड और सिस्टीन स्टोन) को घोलने और बनने से रोकने में मदद करती है। डिस्टल रीनल ट्यूबुलर एसिडोसिस जैसी स्थिति में भी यह शरीर के एसिड-बेस संतुलन को सुधारने के लिए उपयोग की जाती है। यह दवा केवल डॉक्टर के परामर्श से ही लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, पेट में हल्की गैस या दस्त, और मुँह में धातु जैसा स्वाद शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। कभी-कभी पेट में ऐंठन या उल्टी भी हो सकती है। गंभीर दुष्प्रभाव बहुत कम होते हैं, लेकिन अगर आपको भ्रम, मांसपेशियों में ऐंठन, अनियमित दिल की धड़कन, या चेहरे पर सूजन जैसी समस्या हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी स्वास्थ्य समस्याओं के बारे में बताएं, खासकर गुर्दे की बीमारी, दिल की विफलता, उच्च रक्तचाप, या नमक प्रतिबंध वाले आहार के बारे में। इस दवा को लेते समय भरपूर पानी पिएं, जब तक कि डॉक्टर ने तरल पदार्थ प्रतिबंधित न किया हो। एल्युमिनियम युक्त एंटासिड के साथ इस दवा को न लें, क्योंकि इससे एल्युमिनियम का अवशोषण बढ़ सकता है। गर्भावस्था या स्तनपान के दौरान इस दवा का उपयोग करने से पहले डॉक्टर से सलाह लें। दवा की खुराक अपने आप न बदलें और न ही दूसरों के साथ साझा करें।
💊 alkadin 1.25gm syrup Uses & Benefits
[{"condition":"Urinary tract infection (UTI) symptom relief","description":"This medicine helps to reduce the burning and urgency associated with urinary tract infections by making the urine less acidic, which creates an environment less favourable for bacterial growth and soothes irritated urinary tract lining.","evidence":"Well-established"},{"condition":"Kidney stone dissolution (uric acid stones)","description":"By raising urinary pH, this medicine helps to dissolve uric acid stones and prevents their formation in patients who are prone to them.","evidence":"Well-established"},{"condition":"Distal renal tubular acidosis","description":"This medicine is used to correct the metabolic acidosis seen in distal renal tubular acidosis by providing an alkali load.","evidence":"Well-established"},{"condition":"Cystinuria","description":"Alkalinization of urine with this medicine increases the solubility of cystine, helping to prevent cystine stone formation in patients with cystinuria.","evidence":"Established"},{"condition":"Enhancement of certain antibiotic activity","description":"In some urinary tract infections, alkalinizing the urine can improve the effectiveness of antibiotics such as aminoglycosides or certain penicillins.","evidence":"Limited"}]
Off-label uses: [{"condition":"Gout prophylaxis","description":"Sometimes used off-label to alkalinize urine in patients with gout to prevent uric acid stone formation, although this is not a primary approved indication.","evidence":"Limited"},{"condition":"Chemotherapy-induced hemorrhagic cystitis prevention","description":"Rarely, urinary alkalinization may be used off-label to reduce bladder toxicity from certain chemotherapy drugs like cyclophosphamide, but this is not a standard use of this medicine.","evidence":"Limited"}]
Primary treatment for: Urinary tract infections
Also treats: Kidney stones (uric acid and cystine), Distal renal tubular acidosis, Cystinuria
📋 Drug Information
| Generic Name(s) | Disodium Hydrogen Citrate |
| Brand Name | Alkasol Oral Solution |
| Manufacturer | Edinburgh Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | UROLOGY |
| Action Class | Uricosuric agent-gout |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep the bottle tightly closed. Do not freeze. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by providing citrate ions that are metabolized in the body to bicarbonate. The bicarbonate then acts as an alkali, neutralizing excess acid and raising the pH of the urine. This alkalinization effect is the basis for its clinical benefits in conditions where acidic urine contributes to symptoms or stone formation. Additionally, citrate itself can inhibit the crystallization of calcium salts in the urine, further helping to prevent stone formation.
Mechanism Steps
💡 How to Take alkadin 1.25gm syrup
Strength: Each 5 ml of oral liquid contains 1.25 g of disodium hydrogen citrate.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 5 ml to 10 ml (1.25 g to 2.5 g of disodium hydrogen citrate) taken two to four times daily, depending on the indication and the patient's response. For urinary tract infections, it is often taken three times a day. For kidney stone prevention, the dose may be adjusted to maintain urinary pH in a specific range. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Always follow your doctor's prescription exactly. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may be more sensitive to the sodium load and the effects on fluid balance. The dose should be adjusted with caution, and renal function should be monitored. Consult a doctor for individualized dosing. |
| Renal Impairment | In patients with renal impairment, the dose should be reduced or the medicine avoided, as the ability to excrete sodium and bicarbonate is compromised. Consult a nephrologist for dosing guidance. |
| Hepatic Impairment | In patients with hepatic impairment, the metabolism of citrate to bicarbonate may be affected. Caution is advised, and dose adjustment may be necessary. Consult a doctor. |
| Maximum Daily Dose | The maximum daily dose should not exceed 30 ml (7.5 g of disodium hydrogen citrate) unless directed by a doctor. Exceeding this dose may increase the risk of side effects. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of alkadin 1.25gm syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Aluminium-containing antacids | Major | |
| Lithium | Major | |
| Salicylates | Major | |
| Amphetamines | Moderate | |
| Quinidine | Moderate | |
| Methenamine | Moderate | |
| Tetracyclines | Minor | |
| Fluoroquinolones | Minor |
🚨 Major Interactions
- Aluminium-containing antacids
- Lithium
- Salicylates (e.g., aspirin)
⚡ Moderate Interactions
- Amphetamines
- Quinidine
- Methenamine
🍷 Alcohol Interaction
Alcohol may increase the risk of stomach upset and can worsen dehydration. It is advisable to avoid or limit alcohol while taking this medicine, especially if you have a urinary tract infection, as alcohol can irritate the bladder and worsen symptoms.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe renal impairment","Metabolic alkalosis","Hypernatremia","Uncontrolled hypertension","Congestive heart failure","Known hypersensitivity to citrates","Patients on a strict low-sodium diet without medical supervision"]
⚠️ Warnings & Precautions
["Use with caution in patients with mild to moderate renal impairment.","Monitor sodium levels in patients with heart failure or hypertension.","Avoid in patients with active peptic ulcer disease as it may increase gastric irritation.","Do not use for prolonged periods without medical supervision.","Keep out of reach of children.","Inform your doctor if you are pregnant or breastfeeding.","Do not exceed the recommended dose."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk in significant amounts. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose of this medicine can lead to metabolic alkalosis, hypernatremia, and fluid overload. Symptoms may include nausea, vomiting, confusion, muscle twitching, seizures, and irregular heartbeat. If overdose is suspected, seek immediate medical attention. Treatment is supportive and may include discontinuation of the medicine, intravenous fluids, and correction of electrolyte imbalances. In severe cases, dialysis may be considered.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Before starting this medicine, tell your doctor about all your medical conditions, especially kidney disease, heart failure, high blood pressure, or any condition that requires you to limit salt in your diet. Do not take this medicine if you have been told you have metabolic alkalosis or if you have severe kidney impairment. While taking this medicine, drink plenty of water unless your doctor has told you to restrict fluids, because good hydration helps the medicine work and reduces the risk of stone formation. Avoid taking antacids that contain aluminium or calcium at the same time, as they can interfere with the effect of this medicine. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine, as the safety profile in these situations is not fully established. Do not share this medicine with anyone else, even if they have similar symptoms. Keep all follow-up appointments so your doctor can monitor your response and adjust the dose if needed. If you miss a dose, take it as soon as you remember, but if it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Never double the dose to make up for a missed one.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more susceptible to the sodium load and fluid retention caused by this medicine. They may also have reduced kidney function, which can affect the excretion of citrate and bicarbonate. Close monitoring of electrolytes, blood pressure, and kidney function is recommended. The dose may need to be adjusted.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before using this medicine. The safety of this medicine during pregnancy is not well established. Your doctor will weigh the benefits and risks and may recommend alternative treatments if necessary.
🏥 Post-Surgery Considerations
After surgery, especially urological procedures, this medicine may be used to alkalinize urine and prevent clot formation or stone formation. However, it should be used under medical supervision, and fluid and electrolyte balance should be monitored closely.
🦷 Dental Procedures
There are no specific precautions for dental procedures while taking this medicine. However, inform your dentist about all medicines you are taking. If you are scheduled for surgery, tell your surgeon about this medicine as it may affect fluid and electrolyte balance.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
There are no specific exercise restrictions while taking this medicine. However, if you have kidney stones or a urinary tract infection, strenuous exercise may worsen pain or discomfort. Listen to your body and stay well hydrated during exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is unlikely to affect your ability to drive or operate machinery. However, if you experience dizziness or confusion due to electrolyte imbalance, avoid these activities until you feel better. It may cause frequent urination, which can be inconvenient at work; plan your doses and bathroom breaks accordingly.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your symptoms worsen, contact your doctor immediately. For short-term use, such as for a urinary tract infection, you may stop after completing the prescribed course. For long-term use, your doctor will determine when it is safe to stop based on your condition and monitoring results.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to metabolic alkalosis, hypernatremia, and electrolyte imbalances if not monitored. It can also increase the risk of calcium phosphate kidney stones if urinary pH becomes too high. Regular monitoring of urinary pH, serum electrolytes, and kidney function is essential. Your doctor may adjust the dose or recommend periodic breaks. Long-term use should be reviewed periodically to ensure it is still necessary and safe for you.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Drinking plenty of water helps dilute urine and reduce the concentration of stone-forming substances.
Evidence: Well-establishedReducing sodium, purine, and oxalate intake can help prevent kidney stones and reduce the need for alkalinizing agents.
Evidence: Well-establishedAnother urinary alkalinizer that may be preferred in patients who need potassium supplementation or who cannot tolerate sodium load.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. You can receive vaccinations as scheduled. However, if you are acutely ill with a urinary tract infection, your doctor may advise delaying vaccination until you recover.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep the bottle tightly closed
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging with the prescription label intact. Bring a copy of your prescription or a letter from your doctor, especially for international travel. Store it at room temperature and protect it from extreme heat or cold. If you are crossing time zones, continue taking your doses at the same intervals as prescribed; you may need to adjust the timing gradually. Always pack it in your carry-on luggage to avoid loss or temperature extremes in checked baggage. Check customs regulations for carrying liquids and prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts to alkalinize your urine within 1 to 2 hours after taking a dose. You may notice relief from burning within a few hours to a day, but the full effect depends on the underlying condition and other treatments.
A: Yes, it is often prescribed along with antibiotics for urinary tract infections. In fact, alkalinizing the urine can enhance the effectiveness of certain antibiotics. However, always inform your doctor about all medicines you are taking.
A: It can be taken daily for short periods, but long-term use should be monitored by a doctor. Regular monitoring of urinary pH, electrolytes, and kidney function is recommended.
A: Mild side effects like nausea or loose stools usually go away. If you experience severe symptoms like confusion, muscle twitching, or swelling, seek medical attention immediately.
🤔 Common Patient Concerns
🔄 Substitutes for alkadin 1.25gm syrup
View AllAlternative brands with exact same active ingredient:
-
nisalka 1.25gm/5ml syrupKniss Laboratories Pvt Ltd ₹40.31 18.9% CHEAPER
-
dicital 1.25gm syrupDivine Savior Pvt Ltd ₹45.00 9.4% CHEAPER
-
novalka 1.25gm syrupUniversal Micro Sciences ₹46.88 5.7% CHEAPER
-
citalka 1.25gm/5ml syrupOrganic Laboratories ₹47.16 5.1% CHEAPER
-
Tradium SyrupSandMartin Pharmaceuticals Pvt Ltd ₹51.56 3.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any urinary tract infection without antibiotics.
Fact: This medicine only helps to relieve symptoms by alkalinizing urine; it does not kill bacteria. Antibiotics are usually needed to treat the infection. - Myth: This medicine is a painkiller.
Fact: This medicine is not a painkiller. It works by reducing the acidity of urine, which in turn reduces irritation and burning. - Myth: You can take this medicine indefinitely without any monitoring.
Fact: Long-term use requires monitoring of urinary pH, electrolytes, and kidney function. It should be used under medical supervision.
🔄 Alternative Options
Generic Alternatives
- Disodium hydrogen citrate oral solution
Brand Alternatives
- Alkacitral Liquid