aliclin gel - Clindamycin (1% w/w) + Niacinamide (4% w/w) medicine

aliclin gel

4.8 (9 reviews)
๐Ÿญ Alleviate Therapeutics ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 22, 2026
โš ๏ธ Hepatotoxicity Risk ๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 22, 2026

What is aliclin gel used for?

Aliclin Gel (Clindamycin + Niacinamide) is used to treat DERMA. It contains Clindamycin (1% w/w) + Niacinamide (4% w/w), which Clindamycin inhibits bacterial protein synthesis by binding to 50S ribosomal sub. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Clindamycin + Niacinamide
  • Manufacturer: Alleviate Therapeutics
  • Form: Allopathy
  • Pregnancy Category: B
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

๐Ÿ’Š aliclin gel Uses & Benefits

Acne vulgaris

Off-label uses: Rosacea, perioral dermatitis

๐Ÿ“‹ Drug Information

Generic Name(s)Clindamycin + Niacinamide
Brand NameAliclin Gel
ManufacturerAlleviate Therapeutics
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassDERMA
Action ClassTopical Antibiotic + Vitamin B3 Derivative
Route of AdministrationTopical
StorageStore at 20-25ยฐC (68-77ยฐF); protect from light and moisture
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionMinimal systemic absorption after topical application
DistributionPrimarily remains in the skin layers; negligible systemic distribution
Protein BindingClindamycin: 60-94% bound to plasma proteins; Niacinamide: minimal binding
MetabolismClindamycin: Hepatic via CYP3A4; Niacinamide: Hepatic via multiple pathways
Half-LifeClindamycin: 2-3 hours (systemic); Niacinamide: 1-3 hours
ExcretionClindamycin: Renal and biliary; Niacinamide: Renal
BioavailabilityLow systemic bioavailability due to topical route
Onset of ActionWithin 2-4 weeks of regular use
Peak Plasma TimeNot applicable for topical application
Duration of ActionSustained with regular application

How It Works

Clindamycin inhibits bacterial protein synthesis by binding to 50S ribosomal subunit; Niacinamide reduces sebum production and has anti-inflammatory effects

Mechanism Steps

1Clindamycin binds to 50S ribosomal subunit of bacteria, inhibiting peptide bond formation and protein synthesis
2Niacinamide reduces sebum production by inhibiting diacylglycerol acyltransferase
3Niacinamide exerts anti-inflammatory effects by inhibiting cytokine release and neutrophil chemotaxis

๐Ÿ’ก How to Take aliclin gel

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of aliclin gel

โœ… Common Side Effects

  • Skin dryness
  • Peeling
  • Erythema
  • Burning sensation

๐Ÿšจ Serious Side Effects

  • Pseudomembranous colitis
  • Severe allergic reaction

โš ๏ธ Rare Side Effects

  • Contact dermatitis
  • Urticaria

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Erythromycin Major Antagonism of antibacterial effect
Neuromuscular blocking agents Moderate Enhanced neuromuscular blockade
Oral anticoagulants Moderate Possible increased INR
Topical retinoids Minor Increased skin irritation
Benzoyl peroxide Minor Possible inactivation of clindamycin

๐Ÿšจ Major Interactions

  • Erythromycin
  • Other topical antibiotics

โšก Moderate Interactions

  • Neuromuscular blocking agents
  • Oral anticoagulants

โ„น๏ธ Minor Interactions

  • Topical retinoids
  • Benzoyl peroxide

๐Ÿฝ๏ธ Food Interactions

None known

๐Ÿท Alcohol Interaction

No known interaction

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to clindamycin, niacinamide, or any component; history of antibiotic-associated colitis

๐Ÿ“Š Monitoring Parameters

Skin irritation, signs of infection, therapeutic response

๐Ÿคฑ Lactation Safety

Use with caution; minimal systemic absorption expected

๐Ÿ’Š Overdose Management

Unlikely with topical use; if ingested, symptomatic treatment

โฐ Missed Dose

Apply as soon as remembered; skip if almost time for next dose

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

๐Ÿ”— View Profile

โญ User Reviews

Certified Buyer Jul 10, 2026

Found this to be a helpful product. Good results.

Regular Customer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Happy Patient Jul 10, 2026

Found this to be a helpful product. Good results.

Regular Customer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Happy Patient Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

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