alefox-az tablet - Uses, Price, Side Effects & Substitutes
What is alefox-az tablet used for?
Azibact L 500 mg/500 mg Tablet (Levofloxacin + Azithromycin) is used to treat ANTI INFECTIVES. It contains Levofloxacin (250mg) + Azithromycin (250mg), which Levofloxacin inhibits DNA gyrase and topoisomerase IV, preventing bacterial DNA . Always consult your doctor before use. Take as prescribed.
- Generic Name: Levofloxacin + Azithromycin
- Manufacturer: Allenge India
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ alefox-az tablet Uses & Benefits
Community-acquired pneumonia, acute bacterial sinusitis, acute exacerbation of chronic bronchitis, urinary tract infections, skin and soft tissue infections.
Off-label uses: Atypical mycobacterial infections, Legionella, Chlamydia trachomatis infections.
๐ Drug Information
| Generic Name(s) | Levofloxacin + Azithromycin |
| Brand Name | Azibact L 500 mg/500 mg Tablet |
| Manufacturer | Allenge India |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Fluoroquinolone + Macrolide Antibiotic |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Levofloxacin inhibits DNA gyrase and topoisomerase IV, preventing bacterial DNA replication; Azithromycin binds to 50S ribosomal subunit, inhibiting protein synthesis.
Mechanism Steps
๐ก How to Take alefox-az tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of alefox-az tablet
โ Common Side Effects
- Nausea
- Diarrhea
- Headache
- Dizziness
- Abdominal pain
- Vomiting
๐จ Serious Side Effects
- Tendon rupture
- Peripheral neuropathy
- QT prolongation
- Severe hepatotoxicity
- Clostridium difficile colitis
- Seizures
โ ๏ธ Rare Side Effects
- Photosensitivity
- Blood dyscrasias
- Stevens-Johnson syndrome
- Interstitial nephritis
- Hearing loss (azithromycin)
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Antiarrhythmics (Class IA, III) | Major | Increased risk of QT prolongation |
| Theophylline | Major | Increased theophylline levels, toxicity |
| Corticosteroids | Major | Increased risk of tendon rupture |
| NSAIDs | Major | Increased CNS stimulation, seizure risk |
| Antacids (Mg/Al) | Moderate | Decreased levofloxacin absorption |
| Sucralfate | Moderate | Decreased levofloxacin absorption |
| Iron supplements | Moderate | Decreased levofloxacin absorption |
| Zinc | Moderate | Decreased levofloxacin absorption |
| Didanosine | Moderate | Decreased levofloxacin absorption |
| Caffeine | Minor | Increased caffeine effect |
| Cyclosporine | Minor | Increased cyclosporine levels |
| Digoxin | Minor | Increased digoxin levels |
๐จ Major Interactions
- Warfarin
- Antiarrhythmics (Class IA, III)
- Theophylline
- Corticosteroids
- NSAIDs
โก Moderate Interactions
- Antacids (Mg/Al)
- Sucralfate
- Iron supplements
- Zinc
- Didanosine
โน๏ธ Minor Interactions
- Caffeine
- Cyclosporine
- Digoxin
๐ฝ๏ธ Food Interactions
Avoid dairy products, antacids, and iron supplements within 2 hours of levofloxacin; azithromycin may be taken with or without food.
๐ท Alcohol Interaction
Avoid alcohol; may increase risk of hepatotoxicity and CNS effects.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to fluoroquinolones or macrolides, history of tendon disorders with fluoroquinolones, myasthenia gravis, QT prolongation, uncorrected electrolyte disturbances.
๐ Monitoring Parameters
Renal function, liver function, ECG (QT interval), blood glucose, signs of tendonitis or neuropathy.
๐คฑ Lactation Safety
Levofloxacin: Avoid (arthropathy risk); Azithromycin: Use with caution.
๐ Overdose Management
Supportive care; monitor ECG, renal function; hemodialysis ineffective.
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose; do not double.