Alcephin LA 250 mg/250 mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, tongue, or throat
- Difficulty breathing or wheezing
- Severe skin rash with blistering or peeling
- Blood in stool or vomit
- Severe abdominal pain
- Decreased urine output or swelling in the legs
- Yellowing of the skin or eyes
- Persistent high fever
- Unusual bleeding or bruising
- Seizures
If experiencing severe symptoms, call emergency services immediately.
What is alcephin la 250 mg/250 mg tablet used for?
This medicine is a prescription antibiotic combination of cefalexin and probenecid used to treat susceptible bacterial infections. Cefalexin kills bacteria, while probenecid helps keep cefalexin levels higher for longer. It should only be taken under medical supervision.
- Generic Name: Cefalexin + Probenecid
- Manufacturer: Alembic Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 alcephin la 250 mg/250 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा सेफालेक्सिन और प्रोबेनेसिड का संयोजन है, जिसका उपयोग बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है। यह शरीर में एंटीबायोटिक के स्तर को लंबे समय तक बनाए रखने में मदद करती है। इसका उपयोग मूत्र मार्ग संक्रमण, श्वसन तंत्र संक्रमण, त्वचा संक्रमण और हड्डियों के संक्रमण में किया जा सकता है। यह दवा डॉक्टर के पर्चे के बिना नहीं लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, उल्टी, दस्त, पेट दर्द, सिरदर्द और चक्कर आना शामिल हैं। कुछ लोगों को त्वचा पर दाने या खुजली हो सकती है। गंभीर दुष्प्रभावों में सांस लेने में कठिनाई, चेहरे या गले में सूजन, गंभीर त्वचा प्रतिक्रियाएं और गुर्दे की समस्या शामिल हो सकती हैं। अगर कोई भी गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे भोजन के साथ और भरपूर पानी के साथ लें। उपचार के दौरान पर्याप्त मात्रा में तरल पदार्थ पिएं। शराब का सेवन न करें। एंटीबायोटिक का पूरा कोर्स पूरा करें, भले ही आप बेहतर महसूस करें। अन्य दवाओं के बारे में अपने डॉक्टर को बताएं। गुर्दे की बीमारी या एलर्जी हो तो डॉक्टर को सूचित करें।
💊 alcephin la 250 mg/250 mg tablet Uses & Benefits
[{"condition":"Susceptible bacterial infections","description":"Used to treat infections caused by cefalexin-susceptible bacteria, including respiratory tract infections, urinary tract infections, skin and soft tissue infections, and bone infections.","evidence":"Well-established for cefalexin; probenecid is used to prolong antibiotic levels."},{"condition":"Gonorrhea (uncomplicated)","description":"Historically, probenecid has been combined with certain antibiotics to treat uncomplicated gonorrhea by increasing and prolonging antibiotic blood levels.","evidence":"Historical and guideline-based in selected settings; current practice varies."},{"condition":"Urinary tract infections","description":"Cefalexin is active against many common urinary pathogens, and probenecid may help maintain effective antibiotic concentrations.","evidence":"Well-established for cefalexin."},{"condition":"Skin and soft tissue infections","description":"Used for infections such as cellulitis, abscesses, and wound infections caused by susceptible organisms.","evidence":"Well-established for cefalexin."}]
Off-label uses: [{"condition":"Prophylaxis in dental procedures","description":"Sometimes antibiotics are used before dental work in patients at risk of infective endocarditis, but this specific combination is not standard for that purpose.","evidence":"Limited; not a standard off-label use."}]
Primary treatment for: Bacterial infections
Also treats: Urinary tract infections, Respiratory tract infections, Skin and soft tissue infections, Bone infections, Gonorrhea (historical use)
📋 Drug Information
| Generic Name(s) | Cefalexin + Probenecid |
| Brand Name | Alcephin LA 250 mg/250 mg Tablet |
| Manufacturer | Alembic Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporin antibiotic + Uricosuric agent |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep in the original container, tightly closed, away from direct sunlight, heat, and moisture. Do not store in the bathroom. |
| Shelf Life | Typically 24 months from the date of manufacture, but check the expiry date on the pack. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. The World Health Organization does not specifically recommend this fixed-dose combination for routine use. |
| ICMR Guideline | Not established from the available information. The Indian Council of Medical Research has not issued specific guidance on this combination. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Cefalexin is a first-generation cephalosporin antibiotic that kills bacteria by binding to penicillin-binding proteins and blocking the cross-linking of peptidoglycan in the bacterial cell wall. This weakens the cell wall and causes bacterial lysis. Probenecid does not kill bacteria; it inhibits the renal tubular secretion of cefalexin, which raises and prolongs cefalexin concentrations in the blood and tissues. Together, the combination aims to provide more sustained antibiotic exposure than cefalexin alone.
Mechanism Steps
💡 How to Take alcephin la 250 mg/250 mg tablet
Strength: Each tablet contains cefalexin 250 mg and probenecid 250 mg. This is an immediate-release oral tablet.
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the type and severity of infection, kidney function, and other factors. A common adult dose for cefalexin is 250 mg to 500 mg every 6 to 12 hours, but the addition of probenecid changes the dosing schedule. Do not self-medicate. Follow your doctor's prescription exactly, and complete the full course even if you feel better. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced kidney function and are more sensitive to the effects of this medicine. Dose adjustment may be needed based on kidney function. Consult your doctor for individualized dosing. |
| Renal Impairment | Dose adjustment is required in patients with kidney impairment. Cefalexin is removed by the kidneys, and probenecid affects kidney function. Your doctor may reduce the dose or extend the dosing interval based on creatinine clearance. Do not use without medical advice if you have kidney disease. |
| Hepatic Impairment | No specific dose adjustment is established for liver impairment, but caution is advised. Probenecid is metabolized in the liver, so monitor liver function if you have liver disease. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose must be determined by a qualified clinician based on the indication and patient factors. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of alcephin la 250 mg/250 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Methotrexate | Major | |
| Warfarin | Major | |
| Rifampicin | Major | |
| Aspirin | Major | |
| Furosemide | Moderate | |
| Hydrochlorothiazide | Moderate | |
| Ibuprofen | Moderate | |
| Gentamicin | Moderate | |
| Oral contraceptives | Minor | |
| Penicillins | Minor |
🚨 Major Interactions
- Methotrexate
- Warfarin
- Rifampicin
- Salicylates (e.g., aspirin)
⚡ Moderate Interactions
- Loop diuretics (e.g., furosemide)
- Thiazide diuretics
- NSAIDs
- Other nephrotoxic drugs (e.g., aminoglycosides)
🍷 Alcohol Interaction
Alcohol may increase the risk of stomach upset, dizziness, and liver strain. It is best to avoid alcohol while taking this medicine and for a few days after finishing the course.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to cephalosporins or probenecid","Severe kidney disease or kidney failure","Blood disorders such as porphyria","Children under 2 years of age (not established)","Pregnancy unless clearly needed and advised by a doctor","Breastfeeding without medical advice","History of severe allergic reaction to penicillins"]
⚠️ Warnings & Precautions
["Use with caution in patients with kidney disease; dose adjustment may be needed.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Prolonged use may lead to bacterial or fungal superinfections.","May reduce the effectiveness of oral contraceptives; use backup contraception.","Do not use for viral infections such as the common cold or flu.","Inform your doctor if you have a history of seizures, kidney stones, or blood disorders.","Stop the medicine and seek medical help if you develop a severe rash or allergic symptoms."]
🤱 Lactation Safety
Cefalexin passes into breast milk in small amounts and is generally considered compatible with breastfeeding. Probenecid also passes into breast milk, and its effects on a nursing infant are not well established. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
Overdose of this medicine may cause nausea, vomiting, stomach pain, and kidney problems. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and may include activated charcoal if taken recently, intravenous fluids, and monitoring of kidney function and blood counts. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Swallow the tablet whole with a full glass of water, preferably with food to reduce stomach upset. Drink plenty of fluids during treatment to help protect your kidneys, especially because probenecid can increase uric acid handling and urine output. Do not skip doses or stop early, even if you feel better, because incomplete treatment can allow the infection to return or lead to resistance. Avoid alcohol while taking this medicine. Tell your doctor about all other medicines, especially blood thinners, methotrexate, aspirin, or other antibiotics. Do not use this medicine if you are allergic to cephalosporins, penicillins with severe reactions, or probenecid. Keep out of reach of children and store in the original container.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced kidney function and are more prone to side effects. Dose adjustment may be necessary. Monitor kidney function and hydration status closely.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. Cefalexin is generally considered safe, but probenecid should be used with caution. Discuss the risks and benefits with your healthcare provider.
🏥 Post-Surgery Considerations
This medicine may be prescribed after surgery to prevent or treat infection. Follow your surgeon's instructions carefully. Inform your surgical team about all medicines you are taking.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine. It may interact with other medications used during dental procedures. Your dentist may need to adjust your treatment plan.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
You can continue light exercise if you feel well, but avoid strenuous activity if you have fever, dizziness, or fatigue. Listen to your body and rest when needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or tiredness in some people. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their normal daily activities, but take it easy if you feel unwell.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Complete the full course as prescribed, even if you feel better. If you experience severe side effects, contact your doctor immediately for advice.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of antibiotic resistance, fungal infections, and kidney problems. It is not intended for prolonged use unless specifically directed by a doctor. Regular monitoring of kidney function and blood counts may be needed if used for extended periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
May be used if probenecid is not needed.
Evidence: Well-establishedDepending on the infection and susceptibility, other antibiotics may be prescribed.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Antibiotics do not interfere with most vaccines. However, if you are scheduled for a live vaccine, inform your doctor that you are taking this medicine. There is no specific contraindication.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid temperature extremes. If crossing time zones, continue your dosing schedule as close to the prescribed intervals as possible. Check customs regulations for carrying prescription medicines. Store away from direct sunlight and heat.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24 to 48 hours, but you must complete the full course as prescribed.
A: Yes, taking it with food reduces stomach upset.
A: Take it as soon as you remember if it is not almost time for your next dose. Do not double dose.
A: Consult your doctor. Cefalexin is generally considered safe, but probenecid use in pregnancy is limited.
A: It is best to avoid alcohol as it may increase side effects.
🤔 Common Patient Concerns
🔄 Substitutes for alcephin la 250 mg/250 mg tablet
View AllAlternative brands with exact same active ingredient:
-
unifex 250 mg/250 mg tabletBestoChem Formulations India Ltd ₹71.42 14.3% COSTLIER
-
ceff la 250mg/250mg tabletLupin Ltd ₹92.00 47.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Antibiotics can cure the common cold.
Fact: This medicine only works against bacterial infections, not viral infections like the common cold or flu. - Myth: You can stop taking antibiotics once you feel better.
Fact: You must complete the full course as prescribed to prevent the infection from returning and to reduce antibiotic resistance. - Myth: This medicine is safe for everyone.
Fact: It is not safe for people with certain allergies, kidney disease, or blood disorders. Always consult a doctor.
🔄 Alternative Options
Generic Alternatives
- Cefalexin + Probenecid