adesera 10mg tablet - Uses, Price, Side Effects & Substitutes
What is adesera 10mg tablet used for?
Adesera (Adefovir) is used to treat ANTI INFECTIVES. It contains Adefovir (10mg), which Adefovir is a nucleotide analogue that inhibits hepatitis B virus (HBV) DNA poly. Always consult your doctor before use. Take as prescribed.
- Generic Name: Adefovir
- Manufacturer: Cipla Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ adesera 10mg tablet Uses & Benefits
Chronic hepatitis B infection (compensated liver disease) in adults with evidence of active viral replication and elevated liver enzymes.
Off-label uses: HIV infection (in combination with other antiretrovirals, though tenofovir preferred); lamivudine-resistant HBV.
๐ Drug Information
| Generic Name(s) | Adefovir |
| Brand Name | Adesera |
| Manufacturer | Cipla Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Adefovir is a nucleotide analogue that inhibits hepatitis B virus (HBV) DNA polymerase by competing with natural substrates and causing chain termination after incorporation into viral DNA.
Mechanism Steps
๐ก How to Take adesera 10mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of adesera 10mg tablet
โ Common Side Effects
- Asthenia
- Headache
- Nausea
- Diarrhea
- Abdominal pain
- Flatulence
- Dyspepsia
๐จ Serious Side Effects
- Nephrotoxicity (Fanconi syndrome, renal tubular acidosis)
- Hepatotoxicity (hepatic flares)
- Lactic acidosis
- Severe hepatomegaly with steatosis
โ ๏ธ Rare Side Effects
- Pancreatitis
- Peripheral neuropathy
- Osteomalacia (due to renal phosphate wasting)
- Anaphylaxis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Tenofovir | Major | Increased risk of nephrotoxicity |
| Aminoglycosides | Major | Increased risk of nephrotoxicity |
| NSAIDs | Major | Increased risk of nephrotoxicity |
| Probenecid | Moderate | Decreased renal clearance of adefovir |
| Acyclovir | Moderate | Competition for renal tubular secretion |
| Cimetidine | Minor | Possible minor reduction in adefovir clearance |
๐จ Major Interactions
- Tenofovir
- Nephrotoxic drugs (e.g., aminoglycosides, vancomycin, amphotericin B)
- NSAIDs (high dose or chronic use)
โก Moderate Interactions
- Probenecid
- Acyclovir
- Valacyclovir
- Ganciclovir
- Valganciclovir
โน๏ธ Minor Interactions
- Cimetidine
- Famotidine
- Ranitidine
๐ฝ๏ธ Food Interactions
No significant food interactions.
๐ท Alcohol Interaction
Alcohol may exacerbate hepatotoxicity; avoid or limit alcohol consumption.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to adefovir; severe renal impairment (CrCl <10 mL/min) not on dialysis; concurrent use with nephrotoxic drugs (relative).
๐ Monitoring Parameters
Serum creatinine, BUN, urine protein, liver function tests (ALT, AST), HBV DNA levels, HIV status (if applicable).
๐คฑ Lactation Safety
Not recommended; excreted in breast milk in animal studies.
๐ Overdose Management
Supportive care; hemodialysis may remove adefovir (removed by 4-hour dialysis session).
โฐ Missed Dose
Take as soon as remembered unless almost time for next dose; do not double dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for adesera 10mg tablet
View AllAlternative brands with exact same active ingredient (Adefovir (10mg)):
-
adfovir 10mg tabletSun Pharmaceutical Industries Ltd โน270.00 57.2% CHEAPER
-
adheb 10mg tabletSun Pharmaceutical Industries Ltd โน716.53 13.5% COSTLIER
Medical Note: Always consult your doctor before switching medications.