acular ls ophthalmic solution - Ketorolac (0.4% w/v) medicine

acular ls ophthalmic solution

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🏭 Allergan India Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
🤰 Pregnancy Category A 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

What is acular ls ophthalmic solution used for?

This medicine contains Ketorolac (0.4% w/v) and is used to treat OPHTHAL. Inhibits cyclooxygenase (COX-1 and COX-2) enzymes, reducing prostaglandin synthesis.. Always consult your doctor before use.

  • Generic Name: Ketorolac
  • Manufacturer: Allergan India Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 acular ls ophthalmic solution Uses & Benefits

Treatment of ocular inflammation and pain following cataract surgery; relief of seasonal allergic conjunctivitis symptoms.

Off-label uses: Treatment of cystoid macular edema; prevention of intraoperative miosis; management of ocular pain from corneal abrasion.

📋 Drug Information

Generic Name(s)Ketorolac
Brand NameAcular LS Ophthalmic Solution
ManufacturerAllergan India Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassOPHTHAL
Action ClassNSAID's- Non-Selective COX 1&2 Inhibitors (acetic acid)
Route of AdministrationOphthalmic (topical to the eye)
StorageStore at 15-25°C (59-77°F); protect from light; keep bottle tightly closed.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionSystemic absorption is minimal after ophthalmic administration; peak plasma concentrations are low.
DistributionDistributes into ocular tissues; systemic distribution is limited due to low absorption.
Protein Binding99% (primarily to albumin)
MetabolismHepatic metabolism via conjugation and hydroxylation; minor pathways.
Half-Life5-6 hours (systemic); ocular half-life not well defined.
ExcretionRenal excretion of metabolites and unchanged drug (approximately 92% in urine).
BioavailabilityLow systemic bioavailability after ophthalmic use (<5%).
Onset of ActionRapid; within hours for anti-inflammatory effect.
Peak Plasma TimeNot applicable due to low systemic absorption; ocular peak at 1-2 hours.
Duration of Action4-6 hours for anti-inflammatory effect.

How It Works

Inhibits cyclooxygenase (COX-1 and COX-2) enzymes, reducing prostaglandin synthesis.

Mechanism Steps

1Inhibition of cyclooxygenase (COX) enzymes
2Reduction of prostaglandin synthesis from arachidonic acid
3Decreased inflammation and pain in ocular tissues

💡 How to Take acular ls ophthalmic solution

Follow your doctor's prescription exactly.

⚠️ Side Effects of acular ls ophthalmic solution

✅ Common Side Effects

Stinging or burning on instillation
Blurred vision
Conjunctival hyperemia
Eye itching
Headache

🚨 Serious Side Effects

Corneal thinning or perforation
Increased intraocular pressure
Bleeding from ocular surgery
Hypersensitivity reactions

⚠️ Rare Side Effects

Renal impairment
Hepatotoxicity
Bronchospasm
Stevens-Johnson syndrome

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major Increased bleeding risk
Aspirin Major Increased risk of gastrointestinal ulceration and bleeding
Other NSAIDs Major Additive gastrointestinal and renal toxicity
Anticoagulants Major Enhanced anticoagulant effect
Lithium Major Increased lithium levels and toxicity
Methotrexate Major Increased methotrexate toxicity
ACE inhibitors Moderate Reduced antihypertensive effect
Diuretics Moderate Reduced diuretic effect, increased risk of renal impairment
Corticosteroids Moderate Increased risk of gastrointestinal ulceration
Cyclosporine Moderate Increased nephrotoxicity risk
Antacids Minor Possible delayed absorption
Beta-blockers Minor Reduced antihypertensive effect
SSRIs Minor Increased bleeding risk

🚨 Major Interactions

  • Warfarin
  • Aspirin
  • Other NSAIDs
  • Anticoagulants
  • Lithium
  • Methotrexate

⚡ Moderate Interactions

  • ACE inhibitors
  • Diuretics
  • Corticosteroids
  • Cyclosporine

🍷 Alcohol Interaction

Increased risk of gastrointestinal bleeding; avoid concurrent use.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to ketorolac or any component; patients with active peptic ulcer disease; patients with bleeding diathesis; patients with advanced renal disease; patients with aspirin or NSAID-induced asthma.

🤱 Lactation Safety

Caution; limited data; avoid use in nursing mothers.

💊 Overdose Management

Ocular overdose: flush eye with water; systemic overdose unlikely; symptomatic and supportive care.

⏰ Missed Dose

Apply the missed dose as soon as remembered; if near next dose, skip missed dose; do not double dose.

🔄 Substitutes for acular ls ophthalmic solution

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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