acnip 20 capsule - Isotretinoin (20mg) medicine

Acnip 20 Capsule - Uses, Price, Side Effects

4.5 (15 reviews)

Isotretinoin (20mg)

🏭 Dhamus Pharma 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 23, 2026

⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 23, 2026

What is acnip 20 capsule used for?

Acnip 20 Capsule contains Isotretinoin 20mg, a retinoid used to treat severe acne that hasn't responded to other treatments. It works by reducing sebum production, preventing clogged pores, and decreasing inflammation. It is typically taken twice daily with food for 4-6 months.

Generic Name: Isotretinoin
Manufacturer: Dhamus Pharma
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 acnip 20 capsule Uses & Benefits

Severe recalcitrant nodular acne, acne vulgaris unresponsive to other therapies.

Off-label uses: Rosacea, hidradenitis suppurativa, psoriasis, skin cancer prevention.

📋 Drug Information

Generic Name(s)	Isotretinoin
Brand Name	Acutret 10 Capsule
Manufacturer	Dhamus Pharma
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	DERMA
Action Class	Retinoids- First generation
Route of Administration	Oral.
Storage	Store at room temperature (20-25°C), protect from light and moisture.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionAbsorbed orally with high bioavailability; absorption enhanced with food.

DistributionExtensively distributed; crosses placenta; enters breast milk.

Protein Binding99.9% bound to albumin.

MetabolismHepatic metabolism via CYP450 enzymes to active metabolites (4-oxo-isotretinoin).

Half-Life20-24 hours for parent drug; longer for metabolites.

ExcretionExcreted in urine and feces equally.

Bioavailability25% (increased with food).

Onset of Action1-2 weeks for initial improvement.

Peak Plasma Time3-4 hours.

Duration of ActionTherapeutic effect persists weeks after discontinuation.

How It Works

Reduces sebum production, normalizes follicular keratinization, inhibits Propionibacterium acnes growth, and has anti-inflammatory effects.

Mechanism Steps

1Binds to retinoic acid receptors (RARs) and retinoid X receptors (RXRs) in the nucleus.

2Modulates gene transcription involved in cell growth, differentiation, and apoptosis.

3Reduces sebocyte proliferation and sebum production.

💡 How to Take acnip 20 capsule

Follow your doctor's prescription exactly.

Dosage Timeline

🌅 Morning ✅ ☀️ Afternoon ❌ 🌆 Evening ✅ 🌙 Night ❌

⚠️ Side Effects of acnip 20 capsule

✅ Common Side Effects

Cheilitis
Dry skin
Xerophthalmia
Epistaxis
Arthralgia
Myalgia
Headache
Increased triglycerides

🚨 Serious Side Effects

Pseudotumor cerebri
Hepatotoxicity
Pancreatitis
Depression/suicidal ideation
Inflammatory bowel disease
Teratogenicity

⚠️ Rare Side Effects

Thrombocytopenia
Agranulocytosis
Vasculitis
Hearing impairment
Osteoporosis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Tetracyclines	Major	Increased risk of pseudotumor cerebri
Vitamin A supplements	Major	Additive toxic effects
Oral contraceptives	Moderate	Reduced efficacy of contraceptives

🚨 Major Interactions

Tetracyclines
Vitamin A supplements
Methotrexate
Oral contraceptives (reduced efficacy)

⚡ Moderate Interactions

Phenytoin
Corticosteroids
Antifungals (azole)

ℹ️ Minor Interactions

Alcohol
Antacids

🍽️ Food Interactions

High-fat meals increase absorption.

🍷 Alcohol Interaction

May increase risk of hepatotoxicity; avoid concurrent use.

🛡️ Safety & Warnings

Liver

Moderate

Kidney

Low

Heart

Low

Pregnancy

Category A

🚫 Contraindications

Pregnancy, breastfeeding, hypersensitivity to retinoids, hypervitaminosis A, severe hepatic impairment.

📊 Monitoring Parameters

Liver function tests, serum lipids, pregnancy test (monthly), CBC, renal function.

🤱 Lactation Safety

Contraindicated; excreted in breast milk.

💊 Overdose Management

Supportive care; symptoms include headache, vomiting, facial flushing, cheilitis, abdominal pain. No specific antidote.

⏰ Missed Dose

Take as soon as remembered unless near next dose; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 23, 2026

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🔄 Substitutes for acnip 20 capsule

View All

Alternative brands with exact same active ingredient (Isotretinoin (20mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Certified Buyer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Regular Customer Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Happy Patient Jul 10, 2026