acnecort gel - Clindamycin (1% w/w) + Nicotinamide (4% w/w) medicine

Acnecort Gel - Uses, Price, Side Effects

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๐Ÿญ Om Biotec ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 27, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
Dr. SaathiMed Expert Panel | Jun 27, 2026

What is acnecort gel used for?

Acnecort Gel is a combination medicine used to treat acne vulgaris. It contains Clindamycin, an antibiotic that stops bacterial growth, and Nicotinamide, which reduces inflammation and redness. Apply a thin layer to affected areas twice daily as directed by your doctor.

  • Generic Name: Clindamycin + Nicotinamide
  • Manufacturer: Om Biotec
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

๐Ÿ’Š acnecort gel Uses & Benefits

Acne vulgaris, inflammatory acne.

Off-label uses: Rosacea, perioral dermatitis.

๐Ÿ“‹ Drug Information

Generic Name(s)Clindamycin + Nicotinamide
Brand NameAcnetoin Gel
ManufacturerOm Biotec
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassDERMA
Action ClassAntibiotic + Vitamin B3 derivative
Route of AdministrationTopical
StorageStore at room temperature (20-25ยฐC), away from moisture and heat.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionTopical absorption is minimal; systemic absorption is low.
DistributionDistributes locally in skin layers; minimal systemic distribution.
Protein BindingClindamycin: ~94% bound to plasma proteins; Nicotinamide: minimal binding.
MetabolismClindamycin: Hepatic metabolism via CYP3A4; Nicotinamide: Hepatic metabolism to N-methylnicotinamide.
Half-LifeClindamycin: ~2-3 hours; Nicotinamide: ~1-2 hours.
ExcretionClindamycin: Renal and biliary; Nicotinamide: Renal.
BioavailabilityLow systemic bioavailability due to topical application.
Onset of ActionWithin a few days to weeks.
Peak Plasma TimeNot applicable for topical use.
Duration of ActionSustained with regular application.

How It Works

Clindamycin inhibits bacterial protein synthesis by binding to 50S ribosomal subunit; Nicotinamide reduces sebum production and has anti-inflammatory effects.

Mechanism Steps

1Clindamycin binds to 50S ribosomal subunit of bacteria, inhibiting protein synthesis.
2Nicotinamide inhibits sebocyte lipid synthesis and reduces inflammatory cytokine production.
3Combination reduces P. acnes population and inflammation.

๐Ÿ’ก How to Take acnecort gel

Follow your doctor's prescription exactly.

Dosage Timeline

๐ŸŒ… Morning โœ… โ˜€๏ธ Afternoon โŒ ๐ŸŒ† Evening โœ… ๐ŸŒ™ Night โŒ

โš ๏ธ Side Effects of acnecort gel

โœ… Common Side Effects

  • Skin dryness
  • Peeling
  • Erythema
  • Burning sensation

๐Ÿšจ Serious Side Effects

  • Pseudomembranous colitis
  • Severe allergic reactions

โš ๏ธ Rare Side Effects

  • Contact dermatitis
  • Urticaria

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Erythromycin Moderate Increased risk of antibiotic resistance
Neuromuscular blocking agents Moderate Enhanced neuromuscular blockade

๐Ÿšจ Major Interactions

  • Neuromuscular blocking agents
  • Erythromycin

โšก Moderate Interactions

  • Other topical antibiotics
  • Retinoids

โ„น๏ธ Minor Interactions

  • None significant

๐Ÿฝ๏ธ Food Interactions

None known.

๐Ÿท Alcohol Interaction

No known interaction.

๐Ÿ›ก๏ธ Safety & Warnings

Liver
Low
Kidney
Low
Heart
Low
Pregnancy
Category A

๐Ÿšซ Contraindications

Hypersensitivity to clindamycin, nicotinamide, or any component; history of antibiotic-associated colitis.

๐Ÿ“Š Monitoring Parameters

Skin irritation, signs of hypersensitivity, improvement in acne lesions.

๐Ÿคฑ Lactation Safety

Clindamycin is excreted in breast milk; use with caution. Nicotinamide is safe.

๐Ÿ’Š Overdose Management

Topical overdose unlikely; if ingested, symptomatic and supportive care.

โฐ Missed Dose

Apply as soon as remembered; skip if almost time for next dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

Dr. SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 27, 2026

๐Ÿ”— View Profile

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