Acinostop 1gm Injection (Sulbactam): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or shortness of breath
- Swelling of the face, lips, tongue, or throat
- Severe watery diarrhea or diarrhea with fever and abdominal pain
- Rash with blisters, peeling skin, or sores in the mouth or eyes
- Seizures or convulsions
- Decreased urine output or swelling in the legs
- Yellowing of the skin or eyes
- Unusual bleeding or bruising
- Chest pain or irregular heartbeat
- Severe pain or redness at the injection site
If experiencing severe symptoms, call emergency services immediately.
What is acinostop 1gm injection used for?
This medicine contains sulbactam, a beta-lactamase inhibitor used with other antibiotics to treat serious bacterial infections. It is given intravenously by a healthcare professional and works by blocking enzymes that bacteria use to resist antibiotics.
- Generic Name: Sulbactam
- Manufacturer: Glenmark Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 acinostop 1gm injection के बारे में (Hindi Summary)
उपयोग: यह दवा सल्बैक्टम (1 ग्राम) इंजेक्शन है, जिसका उपयोग अस्पताल में गंभीर बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है। यह अकेले काम नहीं करती, बल्कि अन्य एंटीबायोटिक के साथ मिलकर बैक्टीरिया को मारती है। यह उन बैक्टीरिया के खिलाफ प्रभावी है जो आम एंटीबायोटिक्स को तोड़ देते हैं। इसका उपयोग निमोनिया, मूत्र मार्ग संक्रमण, त्वचा संक्रमण, पेट के संक्रमण और रक्त संक्रमण में किया जाता है। यह इंजेक्शन के रूप में नस के माध्यम से दिया जाता है और इसे केवल डॉक्टर या नर्स ही लगा सकते हैं। इसे घर पर स्वयं न लगाएं।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन की जगह पर दर्द, लालिमा या सूजन, दस्त, जी मिचलाना, उल्टी, सिरदर्द और त्वचा पर चकत्ते शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, सांस लेने में कठिनाई, चेहरे या गले में सूजन, गंभीर दस्त, और दौरे पड़ सकते हैं। अगर कोई भी गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल अस्पताल या क्लिनिक में डॉक्टर या नर्स द्वारा ही दी जानी चाहिए। इसे स्वयं न लगाएं। अपने डॉक्टर को अपनी सभी एलर्जी, खासकर पेनिसिलिन या सेफलोस्पोरिन से, और गुर्दे या लीवर की समस्याओं के बारे में बताएं। अपनी सभी दवाओं की जानकारी दें। अगर चकत्ते, सूजन, सांस लेने में तकलीफ या गंभीर दस्त हों तो तुरंत मदद लें। इलाज को अपने आप बंद न करें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर को बताएं।
💊 acinostop 1gm injection Uses & Benefits
[{"condition":"Beta-lactamase-producing bacterial infections","description":"Used in combination with ampicillin or other beta-lactam antibiotics to treat infections caused by bacteria that produce beta-lactamase enzymes, such as respiratory tract infections, urinary tract infections, skin and soft tissue infections, and intra-abdominal infections.","evidence":"Well-established"},{"condition":"Hospital-acquired infections","description":"Part of combination therapy for serious hospital-acquired infections, including pneumonia and bloodstream infections, when beta-lactamase-producing organisms are suspected or confirmed.","evidence":"Well-established"},{"condition":"Surgical prophylaxis","description":"Sometimes used in combination with other antibiotics to prevent surgical site infections in certain procedures, based on local guidelines and patient risk factors.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Acinetobacter infections","description":"Sulbactam has intrinsic activity against some Acinetobacter species and is sometimes used off-label, often in combination with other agents, for multidrug-resistant Acinetobacter infections.","evidence":"Limited"},{"condition":"Burkholderia cepacia infections","description":"Occasionally used off-label in combination therapy for Burkholderia cepacia complex infections, particularly in patients with cystic fibrosis, based on susceptibility testing.","evidence":"Limited"}]
Primary treatment for: Bacterial infections caused by beta-lactamase-producing organisms
Also treats: Respiratory tract infections, Urinary tract infections, Skin and soft tissue infections, Intra-abdominal infections, Gynecological infections, Bone and joint infections, Septicemia
📋 Drug Information
| Generic Name(s) | Sulbactam |
| Brand Name | Acinostop 1gm Injection |
| Manufacturer | Glenmark Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cell wall active agent - Penicillin:Beta-lactamase inhibitors |
| Route of Administration | Intravenous (IV) infusion or injection. It is given by a healthcare professional, usually over 15 to 30 minutes, or as directed by the physician |
| Storage | Store the unopened vial at room temperature between 20°C and 25°C (68°F to 77°F). Protect from light and moisture. Once reconstituted or diluted, the solution should be used within the time specified by the manufacturer, typically within 1 hour for intravenous infusion, or stored as directed. Do not freeze. Keep out of reach of children. |
| Shelf Life | The shelf life of the unopened vial is typically 24 months from the date of manufacture. Check the expiry date on the packaging. Once reconstituted, use immediately or within the recommended time frame. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Sulbactam is a beta-lactamase inhibitor that works by irreversibly binding to and inactivating certain beta-lactamase enzymes produced by bacteria. These enzymes are responsible for breaking down beta-lactam antibiotics, such as penicillins and cephalosporins, making the bacteria resistant. By blocking these enzymes, sulbactam protects the companion antibiotic from destruction, allowing it to reach its target, the penicillin-binding proteins, and inhibit bacterial cell wall synthesis. This leads to bacterial cell death. Sulbactam itself has some intrinsic antibacterial activity against a few organisms, such as Acinetobacter species, but its primary role is to overcome resistance and enhance the effectiveness of the partner antibiotic.
Mechanism Steps
💡 How to Take acinostop 1gm injection
Strength: This medicine is available as a sterile powder for injection containing sulbactam 1gm per vial. It is reconstituted with sterile water for injection or another compatible diluent before intravenous administration.
Dosage Information
| Adult Dosage | The usual adult dose of sulbactam is 1gm given intravenously every 6 to 8 hours, often in combination with ampicillin or another antibiotic. The exact dose and frequency depend on the type and severity of infection, the patient's kidney function, and the companion antibiotic used. For severe infections, higher doses may be used. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-administer. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. The dose is typically based on weight and is determined by the treating physician. |
| Elderly Dosage | Elderly patients may have decreased renal function, which can increase the risk of side effects. Dose adjustment based on creatinine clearance is recommended. The doctor will determine the appropriate dose. |
| Renal Impairment | In patients with renal impairment, the dose and/or dosing interval of sulbactam should be adjusted based on creatinine clearance. For creatinine clearance of 15-29 mL/min, the dose may be reduced or the interval extended. For creatinine clearance less than 15 mL/min, further adjustment is needed. The doctor will determine the exact regimen. |
| Hepatic Impairment | No specific dosage adjustment is recommended for hepatic impairment alone, but caution is advised. Monitor liver function if used in patients with liver disease. |
| Maximum Daily Dose | The maximum recommended daily dose of sulbactam is typically 4gm per day (e.g., 1gm every 6 hours) in adults with normal renal function. Higher doses may be used in certain severe infections under medical supervision. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of acinostop 1gm injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| Probenecid | Moderate | |
| Allopurinol | Moderate | |
| Oral contraceptives | Moderate | |
| Aminoglycosides | Moderate | |
| Loop diuretics | Minor | |
| NSAIDs | Minor | |
| Cephalosporins | Minor | |
| Tetracyclines | Minor |
🚨 Major Interactions
- Warfarin
- Methotrexate
- Probenecid
⚡ Moderate Interactions
- Allopurinol
- Oral contraceptives
- Aminoglycosides
🍷 Alcohol Interaction
There is no direct interaction between alcohol and sulbactam, but alcohol may worsen dehydration, nausea, and diarrhea. It is advisable to avoid alcohol during treatment, especially if you have an infection or are taking other medicines.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe hypersensitivity to sulbactam, penicillins, cephalosporins, or other beta-lactam antibiotics.","Previous history of anaphylaxis or serious allergic reaction to any beta-lactam antibiotic.","Concurrent use with live bacterial vaccines (e.g., typhoid vaccine) may reduce efficacy.","Not for intrathecal or intraocular administration."]
⚠️ Warnings & Precautions
["Serious and occasionally fatal hypersensitivity reactions (anaphylaxis) have been reported. Before starting therapy, inquire about previous hypersensitivity to penicillins, cephalosporins, or other allergens.","Clostridioides difficile-associated diarrhea may occur during or after treatment. If diarrhea develops, evaluate for this condition and manage appropriately.","Use with caution in patients with renal impairment. Dose adjustment is required based on creatinine clearance.","Prolonged use may result in overgrowth of non-susceptible organisms, including fungi. Monitor for superinfections.","Patients with a history of seizures or renal impairment may be at increased risk of seizures. Use with caution.","Safety and effectiveness in pediatric patients have not been established for all indications. Use only as prescribed by a pediatrician.","Elderly patients may have reduced renal function; dose adjustment may be necessary.","Pregnancy: Use only if clearly needed. Lactation: Caution advised; monitor infant for diarrhea or thrush."]
🤱 Lactation Safety
Sulbactam is excreted in human breast milk in small amounts. Caution should be exercised when administered to a nursing woman. The doctor will weigh the benefits of treatment against the potential risks to the infant. If used, monitoring the infant for diarrhea or thrush may be advised.
💊 Overdose Management
Overdose of sulbactam may cause nausea, vomiting, diarrhea, and seizures. There is no specific antidote. Treatment is supportive and symptomatic. In case of overdose, discontinue the drug, monitor vital signs, and manage symptoms. Hemodialysis may be considered to remove sulbactam from the blood in severe cases, especially in patients with renal failure. Contact a poison control center or emergency department immediately.
⏰ Missed Dose
Since this medicine is administered by a healthcare professional, missed doses are unlikely. If a dose is missed, it should be given as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose to catch up. Inform your nurse or doctor if a dose is missed.
Additional Safety Advice
This medicine must be given only by a qualified healthcare professional in a hospital or clinic setting. Do not attempt to self-administer this injection. Inform your doctor about all your allergies, especially to penicillins or cephalosporins, and about any kidney or liver problems. Tell your doctor about all other medicines you are taking, including blood thinners, gout medicines, and other antibiotics. If you develop a rash, swelling, difficulty breathing, or severe diarrhea, seek medical help immediately. Do not stop or change the treatment on your own. Your doctor may monitor your kidney function, liver function, and blood counts during treatment. Pregnant or breastfeeding women should inform their doctor before receiving this medicine. Keep all follow-up appointments and complete the full course as prescribed.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have decreased renal function, which can increase the risk of side effects. Dose adjustment based on creatinine clearance is recommended. Monitor renal function closely. Elderly patients may also be more susceptible to Clostridioides difficile-associated diarrhea and should be monitored for this.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before starting this medicine. It is classified as Pregnancy Category B. Use only if clearly needed. If you become pregnant while on this medicine, inform your doctor immediately.
🏥 Post-Surgery Considerations
This medicine may be used before, during, or after surgery to prevent or treat infections. Follow your surgeon's instructions regarding its use. Monitor for signs of infection at the surgical site. Complete the prescribed course.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine. It may be used prophylactically before dental procedures in patients at risk of infective endocarditis. Your dentist may coordinate with your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While on this medicine, you may feel weak or dizzy. Avoid strenuous exercise until you have recovered. Light activities like walking may be beneficial, but consult your doctor before resuming your regular exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital setting, so you may need to take time off work for treatment. You may experience fatigue, dizziness, or diarrhea, which can affect your ability to work. Avoid driving or operating heavy machinery if you feel unwell. Discuss with your employer about sick leave and follow your doctor's advice before returning to work.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. Your doctor will decide when to stop based on your clinical response and the completion of the prescribed course. If you experience serious side effects, your doctor may discontinue it. Always consult your doctor before stopping.
📅 Long-Term Use Effects
Long-term use of sulbactam may lead to overgrowth of non-susceptible organisms, including fungi, and may increase the risk of Clostridioides difficile-associated diarrhea. Prolonged use may also lead to blood dyscrasias, liver enzyme elevations, and kidney function changes. Regular monitoring of blood counts, liver and kidney function is recommended during prolonged therapy. The risk of seizures may increase in patients with renal impairment. It is important to use this medicine only for the prescribed duration and under medical supervision.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Alternatives include ampicillin-sulbactam, piperacillin-tazobactam, or cefoperazone-sulbactam, depending on the infection and susceptibility.
Evidence: Well-establishedFor infections resistant to other antibiotics, carbapenems may be used as alternatives.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the effectiveness of live bacterial vaccines, such as the typhoid vaccine. Avoid receiving live bacterial vaccines during treatment. Inactivated vaccines are generally safe to administer. Consult your doctor for specific advice.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light and moisture
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Use reconstituted solution within the recommended time
❌ DON'T
Do not use if solution is discolored or contains particles
✈️ Traveling with This Medicine
This medicine is given in a hospital setting, so travel is not applicable. If you are traveling after treatment, carry a copy of your prescription and medical records. Store any remaining medication as directed. For international travel, check customs regulations regarding injectable antibiotics. Always carry medicines in original packaging with the prescription label.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24 to 72 hours after starting treatment, but it is important to complete the full course as prescribed.
A: No, this medicine must be given by a healthcare professional in a hospital or clinic setting.
A: Since it is given by a healthcare professional, missed doses are unlikely. If a dose is missed, inform your nurse or doctor.
A: It is classified as Pregnancy Category B. It should be used during pregnancy only if clearly needed, as determined by your doctor.
A: This medicine may cause dizziness. Avoid driving or operating machinery if you feel dizzy or unwell.
🤔 Common Patient Concerns
🔄 Substitutes for acinostop 1gm injection
View AllAlternative brands with exact same active ingredient:
-
matabac 1gm injectionBiocon ₹178.57 70.1% CHEAPER
-
addbactam 1gm injectionFusion Healthcare Pvt Ltd ₹269.00 55% CHEAPER
-
kiviza 1gm injectionLa Renon Healthcare Pvt Ltd ₹303.75 49.2% CHEAPER
-
sulbacip 1gm injectionCipla Ltd ₹365.63 38.9% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Sulbactam is a standalone antibiotic.
Fact: Sulbactam is primarily a beta-lactamase inhibitor and is usually given with another antibiotic to be effective. - Myth: Sulbactam can be taken orally.
Fact: Sulbactam is not absorbed orally and must be given by injection. - Myth: Sulbactam is safe for everyone.
Fact: It should be avoided in patients with severe beta-lactam allergies and used with caution in kidney disease.
🔄 Alternative Options
Generic Alternatives
- Sulbactam 1gm injection
Brand Alternatives
- Acinostop 1gm injection