acinostop 1gm injection - Sulbactam (1gm) medicine

acinostop 1gm injection - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Glenmark Pharmaceuticals Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 26, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
Dr. SaathiMed Expert Panel | Jun 26, 2026

What is acinostop 1gm injection used for?

Acinostop 1gm Injection (Sulbactam) is used to treat ANTI INFECTIVES. It contains Sulbactam (1gm), which Irreversibly inhibits bacterial beta-lactamases, protecting beta-lactam antibiot. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Sulbactam
  • Manufacturer: Glenmark Pharmaceuticals Ltd
  • Form: Allopathy
  • Pregnancy Category: B
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

๐Ÿ’Š acinostop 1gm injection Uses & Benefits

Treatment of infections caused by beta-lactamase-producing bacteria, including intra-abdominal, gynecologic, skin, and respiratory tract infections; often combined with ampicillin or cefoperazone.

Off-label uses: Bone and joint infections, Neutropenic fever

๐Ÿ“‹ Drug Information

Generic Name(s)Sulbactam
Brand NameAcinostop 1gm Injection
ManufacturerGlenmark Pharmaceuticals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI INFECTIVES
Action ClassCell wall active agent - Penicillin:Beta-lactamase inhibitors
Route of AdministrationIntravenous (IV) or intramuscular (IM) injection.
StorageStore at 20-25ยฐC (68-77ยฐF); protect from moisture; reconstituted solution stable for 1 hour at room temperature.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionIntramuscular administration results in rapid absorption; intravenous administration provides immediate systemic availability.
DistributionWidely distributed in body tissues and fluids, including cerebrospinal fluid when meninges are inflamed.
Protein BindingApproximately 38% bound to plasma proteins.
MetabolismMinimally metabolized; primarily undergoes hydrolysis to inactive metabolites.
Half-LifeApproximately 1 hour in healthy adults; prolonged in renal impairment.
ExcretionPrimarily excreted unchanged in urine (70-80%) via glomerular filtration and tubular secretion.
BioavailabilityNot applicable for IV; IM bioavailability is nearly 100%.
Onset of ActionImmediate (IV); within 30 minutes (IM).
Peak Plasma TimeIV: at end of infusion; IM: 30-60 minutes.
Duration of ActionApproximately 6-8 hours.

How It Works

Irreversibly inhibits bacterial beta-lactamases, protecting beta-lactam antibiotics from hydrolysis, thereby extending their spectrum of activity.

Mechanism Steps

1Sulbactam binds to beta-lactamase enzyme active site.
2Forms a stable acyl-enzyme complex.
3Irreversibly inactivates the beta-lactamase.

๐Ÿ’ก How to Take acinostop 1gm injection

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of acinostop 1gm injection

โœ… Common Side Effects

  • Diarrhea
  • Nausea
  • Vomiting
  • Rash
  • Injection site pain

๐Ÿšจ Serious Side Effects

  • Anaphylaxis
  • Stevens-Johnson syndrome
  • Clostridioides difficile colitis
  • Seizures

โš ๏ธ Rare Side Effects

  • Agranulocytosis
  • Interstitial nephritis
  • Hepatitis

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Aminoglycosides Major Increased nephrotoxicity risk
Probenecid Major Decreased renal excretion of sulbactam
Methotrexate Moderate Reduced methotrexate clearance
Oral contraceptives Moderate Reduced contraceptive efficacy
Warfarin Minor Potentiation of anticoagulant effect
Cyclosporine Minor Possible increased cyclosporine levels

๐Ÿšจ Major Interactions

  • Aminoglycosides
  • Probenecid

โšก Moderate Interactions

  • Methotrexate
  • Oral contraceptives

โ„น๏ธ Minor Interactions

  • Warfarin
  • Cyclosporine

๐Ÿฝ๏ธ Food Interactions

No significant food interactions.

๐Ÿท Alcohol Interaction

No known interaction.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to sulbactam or any beta-lactam antibiotic; history of anaphylactic reaction to penicillins.

๐Ÿ“Š Monitoring Parameters

Renal function (especially in elderly or renally impaired), signs of hypersensitivity, superinfection.

๐Ÿคฑ Lactation Safety

Excreted in breast milk in low amounts; generally considered compatible with breastfeeding.

๐Ÿ’Š Overdose Management

Supportive care; hemodialysis may enhance elimination.

โฐ Missed Dose

Administer as soon as remembered; if near next dose, skip missed dose and resume regular schedule.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

Dr. SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 26, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for acinostop 1gm injection

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Alternative brands with exact same active ingredient (Sulbactam (1gm)):

Medical Note: Always consult your doctor before switching medications.

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