aceno 2mg tablet - Acenocoumarol (2mg) medicine

Acitrom 2 Tablet: Complete Guide To Uses, Side Effects, And Safe Use

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🏭 Zydus Cadila 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 30, 2026
🤰 Pregnancy Category This medicine is contraindicated in pregnancy. It crosses the placenta and can cause fetal bleeding and birth defects. Women of childbearing age should use effective contraception while taking this medicine. If pregnancy is planned or suspected, consult your doctor immediately to switch to a safer alternative. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for approved indications.
Reviewed by
SaathiMed Expert Panel | Oct 30, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Unusual bruising or bleeding that does not stop
  • Confusion or loss of consciousness

If experiencing severe symptoms, call emergency services immediately.

What is aceno 2mg tablet used for?

This medicine is an oral anticoagulant containing acenocoumarol 2 mg. It prevents blood clots by inhibiting vitamin K-dependent clotting factors. It is used for conditions like deep vein thrombosis, atrial fibrillation, and mechanical heart valves. Regular INR monitoring is essential.

  • Generic Name: Acenocoumarol
  • Manufacturer: Zydus Cadila
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 aceno 2mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा एक ओरल एंटीकोआगुलेंट है जिसमें एसेनोकौमारोल 2 मिलीग्राम होता है। यह खून के थक्के बनने से रोकती है और खून को पतला करती है। इसका उपयोग डीप वेन थ्रोम्बोसिस, पल्मोनरी एम्बोलिज्म, एट्रियल फिब्रिलेशन और मैकेनिकल हार्ट वाल्व जैसी स्थितियों में खून के थक्के बनने से रोकने के लिए किया जाता है। यह दवा खून के थक्के बनाने वाले कारकों के उत्पादन को कम करती है। इसका सेवन डॉक्टर के निर्देशानुसार ही करें और नियमित रूप से आईएनआर की जांच कराते रहें।

साइड इफेक्ट्स: इस दवा का सबसे आम दुष्प्रभाव खून बहना है, जैसे आसानी से चोट लगना, मसूड़ों से खून आना या नाक से खून आना। कुछ लोगों को मतली, उल्टी, दस्त, भूख न लगना या त्वचा पर दाने हो सकते हैं। गंभीर मामलों में पेट, आंत या मस्तिष्क में खून बह सकता है, जिसके लिए तुरंत डॉक्टर से मिलना चाहिए। अगर आपको असामान्य खून बहना, चोट लगना या काला मल दिखे तो तुरंत डॉक्टर को बताएं।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, रोज एक ही समय पर। अपनी मर्जी से दवा की मात्रा न बदलें। नियमित रूप से आईएनआर की जांच कराते रहें, क्योंकि इसी के आधार पर डॉक्टर खुराक तय करते हैं। चोट लगने वाले खेलों से बचें। कोई भी नई दवा, हर्बल सप्लीमेंट या पेनकिलर लेने से पहले डॉक्टर या फार्मासिस्ट से सलाह लें। शराब का सेवन न करें या बहुत कम करें। अगर दवा लेना भूल जाएं तो डॉक्टर की सलाह लें, दोहरी खुराक न लें। दवा को बच्चों से दूर, ठंडी और सूखी जगह पर रखें।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 aceno 2mg tablet Uses & Benefits

[{"condition":"Deep vein thrombosis (DVT)","description":"Used to prevent and treat blood clots in deep veins, usually after initial treatment with heparin.","evidence":"Well-established"},{"condition":"Pulmonary embolism (PE)","description":"Helps prevent and treat blood clots that travel to the lungs.","evidence":"Well-established"},{"condition":"Atrial fibrillation","description":"Reduces the risk of stroke by preventing clot formation in the heart.","evidence":"Well-established"},{"condition":"Mechanical heart valves","description":"Prevents clot formation on artificial heart valves.","evidence":"Well-established"},{"condition":"Post-surgical clot prevention","description":"Used after certain surgeries to prevent blood clots.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Antiphospholipid syndrome","description":"Sometimes used off-label to prevent clots in this autoimmune condition.","evidence":"Limited"},{"condition":"Recurrent pregnancy loss","description":"Rarely used in selected cases, but generally avoided in pregnancy due to risks.","evidence":"Limited"}]

Primary treatment for: Thromboembolic disorders

Also treats: Atrial fibrillation, Deep vein thrombosis, Pulmonary embolism, Mechanical heart valves

📋 Drug Information

Generic Name(s)Acenocoumarol
Brand NameAcitrom 2 Tablet
ManufacturerZydus Cadila
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action ClassVitamin K antagonists
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture, heat, and direct sunlight. Keep in the original container, tightly closed.
Shelf LifeTypically 2 years from the date of manufacture. Check the expiry date on the pack.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine at the same time every day, preferably in the evening.
2
Never skip your INR blood tests; they are crucial for your safety.
3
Inform your dentist, surgeon, or any new doctor that you are on this medicine.
4
Use a soft toothbrush and an electric razor to minimize bleeding.
5
Avoid sudden changes in your diet, especially green leafy vegetables.
6
Carry a medical alert card or wear a bracelet stating you are on anticoagulant therapy.
7
Do not take any new medicine, including over-the-counter drugs, without consulting your doctor.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Blood clot prevention
This medicine is commonly prescribed for this.
Likely Use
❌
Fever
This medicine is not a fever reducer.
Not Primary
❌
Pain relief
This medicine is not a painkiller.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionThis medicine is rapidly absorbed from the gastrointestinal tract after oral administration. The bioavailability is high, approximately 60-100%. Food does not significantly affect absorption.
DistributionThis medicine is highly bound to plasma proteins, primarily albumin. It crosses the placenta and is distributed into breast milk. The volume of distribution is relatively small.
Protein BindingApproximately 98-99% bound to plasma proteins, mainly albumin.
MetabolismThis medicine is metabolized in the liver by cytochrome P450 enzymes, primarily CYP2C9, CYP1A2, and CYP3A4. The metabolites are inactive and are excreted mainly in urine and bile.
Half-LifeThe elimination half-life is approximately 8-11 hours, but the anticoagulant effect lasts longer because it depends on the half-life of clotting factors (especially factor II, which has a half-life of about 60 hours).
ExcretionMetabolites are excreted primarily in the urine (about 60%) and in the bile/feces (about 40%).
BioavailabilityApproximately 60-100%.
Onset of ActionThe anticoagulant effect begins within 24-48 hours, but full therapeutic effect takes 3-5 days.
Peak Plasma TimePeak plasma concentration is reached within 1-4 hours after oral administration.
Duration of ActionThe anticoagulant effect lasts for 2-5 days after discontinuation, depending on the INR and clotting factor levels.

How It Works

This medicine works by inhibiting the enzyme vitamin K epoxide reductase, which is needed to recycle vitamin K in the liver. By blocking this enzyme, it reduces the active form of vitamin K, which in turn decreases the production of clotting factors II, VII, IX, and X, as well as proteins C and S. This leads to prolonged clotting time and prevents unwanted blood clot formation.

Mechanism Steps

1
Inhibition of VKORC1: This medicine binds to and inhibits the enzyme vitamin K epoxide reductase (VKORC1) in the liver.
2
Reduced vitamin K recycling: This inhibition prevents the regeneration of reduced vitamin K, which is essential for the gamma-carboxylation of clotting factors.
3
Decreased clotting factor synthesis: Without sufficient reduced vitamin K, the liver cannot produce fully functional clotting factors II, VII, IX, and X, as well as proteins C and S.
4
Prolonged clotting time: The reduced levels of active clotting factors lead to a prolonged prothrombin time and increased INR, resulting in anticoagulation.

💡 How to Take aceno 2mg tablet

Strength: Acenocoumarol 2 mg immediate-release tablet.

1Take this medicine orally with a glass of water.
2Take it at the same time each day, preferably in the evening.
3You may take it with or without food, but be consistent.
4Swallow the tablet whole; do not crush or chew.
5Do not change your dose without consulting your doctor.
6Keep a record of your doses and INR results.

Dosage Information

Adult DosageThe dose of this medicine is highly individualized and must be determined by a qualified clinician based on the indication, target INR, age, weight, renal and hepatic function, and concomitant medications. A common starting dose is 2 mg to 4 mg once daily, but the maintenance dose varies widely from 1 mg to 10 mg daily. Regular INR monitoring is mandatory to adjust the dose. Never self-adjust the dose. Always follow your doctor's prescription exactly.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of this medicine and are at higher risk of bleeding. Lower doses may be required, and INR should be monitored more frequently. Consult your doctor for individualized dosing.
Renal ImpairmentDose adjustment may be necessary in patients with renal impairment. Close monitoring of INR and renal function is advised. Consult your doctor for specific dosing recommendations.
Hepatic ImpairmentThis medicine is contraindicated in severe liver disease. In mild to moderate hepatic impairment, dose reduction and close monitoring are required. Consult your doctor for individualized dosing.
Maximum Daily DoseThe maximum daily dose is individualized based on INR response. It rarely exceeds 10 mg per day, but must be determined by a clinician.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
Avoid
May increase drug levels.
Leafy greens
Maintain consistent intake
Vitamin K can affect INR.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of aceno 2mg tablet

✅ Common Side Effects

Minor bleeding (bruising, gum bleeding, nosebleeds) (Common (up to 10%))
Apply pressure to stop bleeding. Inform your doctor if bleeding is frequent or prolonged.
Nausea (Common (1-10%))
Take with food to reduce nausea. Consult doctor if persistent.
Diarrhea (Common (1-10%))
Stay hydrated. Consult doctor if severe or persistent.
Loss of appetite (Common (1-10%))
Eat small, frequent meals. Consult doctor if weight loss occurs.
Skin rash (Uncommon (0.1-1%))
Consult doctor if rash develops. Do not stop medicine without advice.

🚨 Serious Side Effects

Major bleeding (gastrointestinal, intracranial, or other internal bleeding) (Rare (<0.1%))
Seek immediate medical attention if you notice black or bloody stools, vomiting blood, severe headache, confusion, or unexplained bruising.
Skin necrosis (Rare (<0.1%))
Seek immediate medical attention if you develop painful, dark, or necrotic skin lesions, especially in the first weeks of treatment.
Purple toe syndrome (Rare (<0.1%))
Report blue-purple discoloration and pain in toes to your doctor immediately.
Hypersensitivity reactions (anaphylaxis) (Very rare (<0.01%))
Seek emergency care if you experience swelling of face, lips, throat, difficulty breathing, or severe rash.

⚠️ Rare Side Effects

Hair loss
Consult doctor if hair loss is bothersome. It is usually reversible.
Jaundice
Seek medical attention if you notice yellowing of skin or eyes.
Vasculitis
Report unexplained fever, rash, or joint pain to your doctor.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Ibuprofen Major
Aspirin Major
Fluconazole Major
Erythromycin Major
Rifampicin Major
Amiodarone Major
Paracetamol Moderate
Omeprazole Moderate
St. John's wort Moderate

🚨 Major Interactions

  • Warfarin
  • NSAIDs (e.g., ibuprofen, aspirin)
  • Antiplatelet drugs (e.g., clopidogrel)
  • Azole antifungals (e.g., fluconazole, ketoconazole)
  • Macrolide antibiotics (e.g., erythromycin, clarithromycin)
  • Rifampicin
  • Amiodarone
  • Thyroid hormones

⚡ Moderate Interactions

  • Paracetamol (acetaminophen)
  • Corticosteroids
  • Tramadol
  • Selective serotonin reuptake inhibitors (SSRIs)
  • Omeprazole

🍷 Alcohol Interaction

Alcohol can interact with this medicine in complex ways. Acute heavy drinking may increase the anticoagulant effect and bleeding risk, while chronic heavy drinking may reduce it. It is best to avoid alcohol or limit intake to no more than one drink per day and inform your doctor about your alcohol consumption.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Pregnancy","Active bleeding or high risk of bleeding","Severe liver disease","Severe kidney disease","Uncontrolled severe hypertension","Recent intracranial hemorrhage","Known hypersensitivity to acenocoumarol","Lack of ability to monitor INR regularly"]

⚠️ Warnings & Precautions

["Regular INR monitoring is essential to prevent bleeding or clotting complications.","Inform all healthcare providers that you are taking this medicine.","Avoid contact sports or activities with high risk of injury.","Use a soft toothbrush and electric razor to reduce bleeding risk.","Many drugs and foods interact with this medicine; always consult before taking anything new.","Do not stop this medicine abruptly without medical advice.","Carry a medical alert card or wear a bracelet stating you are on anticoagulant therapy."]

🤱 Lactation Safety

This medicine is excreted in breast milk in small amounts. It is generally considered compatible with breastfeeding, but the infant should be monitored for bleeding. Consult your doctor before breastfeeding.

💊 Overdose Management

Overdose of this medicine can cause severe bleeding. If you suspect an overdose, seek emergency medical care immediately. Treatment may include administration of vitamin K, fresh frozen plasma, or prothrombin complex concentrate, depending on the severity of bleeding and INR levels. Do not attempt to treat yourself.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember on the same day. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, contact your doctor or pharmacist.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor, at the same time each day. Never change your dose without medical advice. You must have regular blood tests to check your INR, as the dose is adjusted based on these results. Avoid activities that can cause injury or bleeding, such as contact sports. Tell all your healthcare providers, including dentists, that you are taking this medicine. Many other medicines, including over-the-counter pain relievers, antibiotics, and herbal supplements, can interact with this medicine, so always consult your doctor or pharmacist before taking anything new. Avoid alcohol or limit it strictly, as it can affect your INR. If you miss a dose, follow your doctor's instructions; do not double the dose. Keep this medicine out of reach of children. Store it at room temperature, away from moisture and direct sunlight.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of bleeding and may require lower doses. More frequent INR monitoring is advised. Falls should be avoided.

🤰 Pregnancy Planning (TTC)

This medicine is contraindicated in pregnancy. Women planning pregnancy should consult their doctor to switch to a safer alternative before conception.

🏥 Post-Surgery Considerations

After surgery, this medicine may be restarted once bleeding risk is acceptable. Close monitoring of INR is essential. Inform your surgeon about your medication.

🦷 Dental Procedures

Inform your dentist about this medicine before any dental procedure. You may need to adjust your dose or take extra precautions to control bleeding.

💚 Lifestyle Tips for Better Results

🏃
Maintain a consistent diet, especially regarding vitamin K-rich foods.
🥗
Avoid contact sports and activities with high risk of injury.
😴
Use a soft toothbrush and electric razor.
💧
Wear a medical alert bracelet.
🧘
Keep all your medical appointments and INR tests.
🌞
Limit alcohol consumption.

🏋️ Exercise Considerations

Avoid contact sports and activities that can cause bleeding or injury. Low-impact exercises like walking, swimming, and cycling are generally safe. Consult your doctor before starting any new exercise routine.

🥗 Diet Recommendations

Maintain a consistent intake of vitamin K-rich foods like spinach, broccoli, and kale.
Avoid grapefruit juice.
Limit alcohol.
Stay well hydrated.
Eat a balanced diet.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or fatigue in some people. Avoid driving or operating heavy machinery if you feel unwell. Inform your employer about your medication, especially if your job involves risk of injury.

🛑 When to Stop This Medicine

Do not stop this medicine without your doctor's advice. Stopping abruptly can increase the risk of blood clots. Your doctor will decide when it is safe to stop based on your condition and INR results.

📅 Long-Term Use Effects

Long-term use of this medicine requires regular INR monitoring to prevent bleeding or clotting complications. It can increase the risk of osteoporosis with prolonged use. Periodic liver and kidney function tests are advised. Do not stop the medicine without consulting your doctor, as it can lead to dangerous blood clots.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Direct oral anticoagulants (DOACs)

Newer anticoagulants like rivaroxaban or apixaban may be alternatives, but they have different monitoring and side effect profiles.

Evidence: Well-established
Compression stockings

Can help prevent DVT in some cases, but not a substitute for anticoagulation.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

Vaccinations are generally safe while on this medicine. However, intramuscular injections may increase the risk of bleeding. Inform the vaccinator about your medication and apply pressure after the injection.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss. If crossing time zones, consult your doctor about adjusting the timing of your dose. Store it at room temperature and avoid extreme heat or cold. Carry enough supply for your entire trip. Inform airport security that you are carrying medication. Have a medical alert card stating you are on anticoagulant therapy.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 55-year-old man with atrial fibrillation
He was prescribed this medicine to prevent stroke. He initially found it difficult to manage the INR tests, but with regular monitoring and a consistent diet, his INR stabilized. He now leads an active life and understands the importance of never missing a dose.
💡 Lesson: Regular INR monitoring and a consistent lifestyle are key to safely managing anticoagulant therapy.
👤 A 40-year-old woman after deep vein thrombosis
After a DVT, she started this medicine. She experienced some bruising initially but learned to avoid contact sports and use a soft toothbrush. She emphasizes the importance of informing all doctors about her medication.
💡 Lesson: Simple precautions like using a soft toothbrush and avoiding injury can reduce bleeding risk.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine starts working within 24-48 hours, but full effect takes 3-5 days. Regular INR monitoring helps track its effect.

Q: What should I do if I miss a dose?

A: If you remember within a few hours, take it. If it's almost time for the next dose, skip it. Never double dose.

Q: Can I take this medicine with other painkillers?

A: Only acetaminophen (paracetamol) is generally safe. Avoid NSAIDs like ibuprofen or aspirin as they increase bleeding risk.

Q: Is it safe to become pregnant while on this medicine?

A: No, this medicine is contraindicated in pregnancy. Use effective contraception and consult your doctor if planning pregnancy.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for aceno 2mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: Acitrom 2 tablet can be taken without regular blood tests.
    Fact: Regular INR monitoring is mandatory to ensure safety and effectiveness.
  • Myth: Acitrom 2 tablet is a painkiller.
    Fact: It is an anticoagulant, not a painkiller.
  • Myth: You can stop acitrom 2 tablet once you feel better.
    Fact: Never stop without doctor's advice, as it can lead to dangerous clots.
  • Myth: Acitrom 2 tablet interacts with all foods.
    Fact: Only vitamin K-rich foods need consistent intake; others are generally fine.

🔄 Alternative Options

Generic Alternatives

  • Acenocoumarol 2 mg tablet

Brand Alternatives

  • Acitrom 2 tablet

📊 Comparison with Similar Medicines

[{"medicine":"Acenocoumarol","class":"Vitamin K antagonist","monitoring":"INR required","half_life":"8-11 hours"},{"medicine":"Warfarin","class":"Vitamin K antagonist","monitoring":"INR required","half_life":"20-60 hours"},{"medicine":"Rivaroxaban","class":"Direct factor Xa inhibitor","monitoring":"No routine monitoring","half_life":"5-13 hours"}]

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