Ampilox C DS 500 mg/500 mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of face, lips, or throat
- Severe diarrhea or abdominal pain
- Seizures or confusion
- Decreased urine output or swelling
- Unusual bleeding or bruising
- Yellowing of skin or eyes
- Severe rash or blistering
If experiencing severe symptoms, call emergency services immediately.
What is ace 500mg/500mg injection used for?
This medicine is a combination antibiotic injection containing Ampicillin and Cloxacillin. It is used to treat serious bacterial infections when oral antibiotics are not suitable. It works by killing bacteria and is given by a healthcare professional.
- Generic Name: Ampicillin (500mg) + Cloxacillin (500mg)
- Manufacturer: Oscar Remedies Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ace 500mg/500mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा एम्पीसिलिन और क्लोक्सासिलिन का संयोजन है, जो एक एंटीबायोटिक इंजेक्शन है। इसका उपयोग त्वचा, हड्डियों, श्वसन तंत्र और मूत्र मार्ग के गंभीर बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है। यह बैक्टीरिया को मारकर काम करती है। यह केवल डॉक्टर के निर्देश पर ही दी जाती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में इंजेक्शन स्थल पर दर्द, दस्त, मतली, उल्टी और त्वचा पर दाने शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी, गंभीर दस्त और दौरे पड़ सकते हैं। किसी भी असामान्य लक्षण पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए। खुद से इंजेक्शन न लगाएं। अपने डॉक्टर को अपनी सभी एलर्जी और बीमारियों के बारे में बताएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। पूरा कोर्स पूरा करें।
💊 ace 500mg/500mg injection Uses & Benefits
[{"condition":"Skin and soft tissue infections","description":"Effective against cellulitis, abscesses, and wound infections caused by susceptible gram-positive and gram-negative bacteria.","evidence":"Well-established"},{"condition":"Bone and joint infections","description":"Used in osteomyelitis and septic arthritis when caused by susceptible organisms, especially Staphylococcus aureus.","evidence":"Well-established"},{"condition":"Respiratory tract infections","description":"Treats pneumonia, bronchitis, and other lower respiratory infections caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Used for complicated or severe UTIs when oral therapy is not feasible.","evidence":"Well-established"},{"condition":"Surgical prophylaxis","description":"Given before certain surgeries to prevent postoperative infections.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Listeria meningitis","description":"Ampicillin is sometimes used off-label in combination with other antibiotics for Listeria monocytogenes meningitis.","evidence":"Limited"},{"condition":"Enterococcal endocarditis","description":"Ampicillin may be used off-label with gentamicin for enterococcal endocarditis.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Skin infections, Bone infections, Respiratory infections, Urinary tract infections
📋 Drug Information
| Generic Name(s) | Ampicillin (500mg) + Cloxacillin (500mg) |
| Brand Name | ace 500mg/500mg injection |
| Manufacturer | Oscar Remedies Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Parenteral (intramuscular or intravenous injection) |
| Storage | Store below 25°C in a dry place, protected from light. Reconstituted solutions should be used immediately or stored as directed by the manufacturer. Do not freeze. |
| Shelf Life | Typically 24 months from the date of manufacture. Refer to the product label for exact expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by inhibiting bacterial cell wall synthesis. Ampicillin binds to penicillin-binding proteins (PBPs) and inhibits transpeptidation, leading to weakened cell walls and bacterial lysis. Cloxacillin also binds to PBPs but is resistant to penicillinase enzymes produced by certain bacteria, allowing it to effectively kill penicillinase-producing Staphylococcus aureus.
Mechanism Steps
💡 How to Take ace 500mg/500mg injection
Strength: Injection: Ampicillin 500 mg + Cloxacillin 500 mg per vial.
Dosage Information
| Adult Dosage | The dose is individualized by a qualified clinician based on the type and severity of infection, patient's weight, renal and hepatic function. Typical adult doses range from 500 mg to 2 g every 4-6 hours by intramuscular or intravenous injection. For severe infections, higher doses may be used. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal function and require dose adjustment. Monitor renal function closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Dose adjustment is required in renal impairment. For creatinine clearance less than 10 mL/min, reduce dose or increase dosing interval. Consult a nephrologist or clinical pharmacist for specific guidance. |
| Hepatic Impairment | No specific dose adjustment is established for hepatic impairment, but use with caution and monitor liver function. |
| Maximum Daily Dose | Maximum daily dose is not established from available information. Doses up to 12 g per day have been used in severe infections under close medical supervision. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ace 500mg/500mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| Probenecid | Moderate | |
| Allopurinol | Moderate | |
| Oral contraceptives | Moderate |
🚨 Major Interactions
- Warfarin
- Methotrexate
- Probenecid
⚡ Moderate Interactions
- Allopurinol
- Oral contraceptives
🍷 Alcohol Interaction
Alcohol may worsen gastrointestinal side effects and should be avoided during treatment. It does not directly interact with the medicine but can increase the risk of nausea, vomiting, and diarrhea.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to penicillins or cephalosporins","History of severe allergic reaction to any beta-lactam antibiotic","Infectious mononucleosis (increased risk of rash with ampicillin)"]
⚠️ Warnings & Precautions
["Use with caution in patients with renal impairment; dose adjustment may be needed.","Use with caution in patients with hepatic impairment.","May cause false-positive results in urine glucose tests.","Prolonged use may lead to superinfection with resistant organisms.","Ensure adequate hydration during treatment.","Do not use for viral infections."]
🤱 Lactation Safety
Ampicillin and Cloxacillin are excreted in breast milk in small amounts. They are generally considered safe during breastfeeding, but monitor the infant for diarrhea or thrush. Consult your doctor before use.
💊 Overdose Management
Overdose may cause nausea, vomiting, diarrhea, and seizures. There is no specific antidote. Treatment is supportive and symptomatic. Hemodialysis may be considered to remove ampicillin from the blood in severe cases. Contact a poison control center or emergency department immediately.
⏰ Missed Dose
Since this medicine is administered by a healthcare professional, missed doses are unlikely. If you miss a scheduled dose, contact your doctor or nurse as soon as possible. Do not attempt to self-administer.
Additional Safety Advice
This medicine must be administered by a healthcare professional only. Do not self-administer. Inform your doctor about any allergies, especially to penicillins or cephalosporins. Tell your doctor if you have kidney or liver disease, or if you are pregnant or breastfeeding. Complete the full course as prescribed, even if you feel better. Do not skip doses. Report any signs of allergic reaction, severe diarrhea, or unusual bleeding immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of kidney impairment and may require dose adjustment. Monitor renal function closely. Watch for signs of confusion or seizures.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before using this medicine. Penicillins are generally considered safe in pregnancy but use only if clearly needed.
🏥 Post-Surgery Considerations
This medicine is often used to prevent or treat surgical site infections. Follow your surgeon's instructions for duration and monitoring.
🦷 Dental Procedures
This medicine may be used as prophylaxis before dental procedures in patients at risk of infective endocarditis. Consult your dentist and doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise if you have fever or severe infection. Rest is important for recovery. Light activity may be resumed as you feel better.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
You may need to take time off work for injections and recovery. Driving may be affected if you experience dizziness or fatigue. Avoid operating machinery until you know how this medicine affects you.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Complete the full course even if you feel better. If you experience severe side effects, contact your doctor immediately.
📅 Long-Term Use Effects
Long-term use may lead to antibiotic resistance, superinfections, and rare blood or liver abnormalities. Regular monitoring of kidney and liver function is advised for prolonged therapy. Use only as long as prescribed.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
May be used if the infection is mild and oral therapy is feasible.
Evidence: Well-establishedDepending on culture and sensitivity results, other antibiotics may be more appropriate.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions reported. However, antibiotics may reduce the effectiveness of live bacterial vaccines like typhoid vaccine. Consult your doctor.
📦 Storage Guide
✅ DO
Store below 25°C in a dry place
❌ DON'T
Do not freeze
✅ DO
Protect from light
❌ DON'T
Do not use if solution is discolored or contains particles
✅ DO
Use reconstituted solution immediately
❌ DON'T
Do not store reconstituted solution for long periods
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in a cool, dry place away from direct sunlight. If traveling by air, carry it in your hand luggage. Check customs regulations for importing medicines. Since it is an injectable, it should be administered by a healthcare professional at your destination.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 30 minutes after injection, but you may feel better after 24-48 hours. Complete the full course as prescribed.
A: No, this medicine must be administered by a healthcare professional in a clinic or hospital setting.
A: Report any side effects to your doctor immediately. Severe reactions require emergency medical attention.
🤔 Common Patient Concerns
🔄 Substitutes for ace 500mg/500mg injection
View AllAlternative brands with exact same active ingredient:
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Synaclox 500mg/500mg InjectionAgron Remedies Pvt Ltd ₹11.97 19% CHEAPER
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bactimox 500mg/500mg injectionTaurus Laboratories Pvt Ltd ₹12.48 15.5% CHEAPER
-
ace 500 mg/500 mg injectionSwiss Pharma Pvt Ltd ₹12.50 15.4% CHEAPER
-
mix 500 mg/500 mg injectionShrinivas Gujarat Laboratories Pvt Ltd ₹12.56 15% CHEAPER
-
Tobiotic 500mg/500mg InjectionNeon Laboratories Ltd ₹12.76 13.6% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections like cold and flu.
Fact: This medicine is an antibiotic and only works against bacterial infections. It is not effective against viruses. - Myth: You can stop taking this medicine once you feel better.
Fact: You must complete the full course as prescribed to prevent recurrence and resistance.
🔄 Alternative Options
Generic Alternatives
- Ampicillin + Cloxacillin injection (generic)
Brand Alternatives
- Ampilox C DS 500 mg/500 mg injection