accufine 10mg softgel capsule - Isotretinoin (10mg) medicine

Accufine 10mg Softgel Capsule - Uses, Price, Side Effects

4.4 (13 reviews)

Isotretinoin (10mg)

🏭 Healing Pharma India Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is accufine 10mg softgel capsule used for?

Accufine 10mg Softgel Capsule contains Isotretinoin, a retinoid used to treat severe nodular acne that has not responded to other treatments. It works by reducing sebum production, decreasing acne-causing bacteria, and preventing clogged pores. It is taken with food twice daily under medical supervision.

Generic Name: Isotretinoin
Manufacturer: Healing Pharma India Pvt Ltd
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 accufine 10mg softgel capsule Uses & Benefits

Severe recalcitrant nodular acne, acne vulgaris unresponsive to other therapies.

Off-label uses: Rosacea, hidradenitis suppurativa, psoriasis, skin cancer prevention.

📋 Drug Information

Generic Name(s)	Isotretinoin
Brand Name	Acutret 10 Capsule
Manufacturer	Healing Pharma India Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	DERMA
Action Class	Retinoids- First generation
Route of Administration	Oral.
Storage	Store at room temperature (20-25°C), protect from light and moisture.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionAbsorbed orally with high bioavailability; absorption enhanced with food.

DistributionExtensively distributed; crosses placenta; enters breast milk.

Protein Binding99.9% bound to albumin.

MetabolismHepatic metabolism via CYP450 enzymes to active metabolites (4-oxo-isotretinoin).

Half-Life20-24 hours for parent drug; longer for metabolites.

ExcretionExcreted in urine and feces equally.

Bioavailability25% (increased with food).

Onset of Action1-2 weeks for initial improvement.

Peak Plasma Time3-4 hours.

Duration of ActionTherapeutic effect persists weeks after discontinuation.

How It Works

Reduces sebum production, normalizes follicular keratinization, inhibits Propionibacterium acnes growth, and has anti-inflammatory effects.

Mechanism Steps

1Binds to retinoic acid receptors (RARs) and retinoid X receptors (RXRs) in the nucleus.

2Modulates gene transcription involved in cell growth, differentiation, and apoptosis.

3Reduces sebocyte proliferation and sebum production.

💡 How to Take accufine 10mg softgel capsule

Follow your doctor's prescription exactly.

Dosage Timeline

🌅 Morning ✅ ☀️ Afternoon ❌ 🌆 Evening ✅ 🌙 Night ❌

⚠️ Side Effects of accufine 10mg softgel capsule

✅ Common Side Effects

Cheilitis
Dry skin
Xerophthalmia
Epistaxis
Arthralgia
Myalgia
Headache
Increased triglycerides

🚨 Serious Side Effects

Pseudotumor cerebri
Hepatotoxicity
Pancreatitis
Depression/suicidal ideation
Inflammatory bowel disease
Teratogenicity

⚠️ Rare Side Effects

Thrombocytopenia
Agranulocytosis
Vasculitis
Hearing impairment
Osteoporosis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Vitamin A supplements	Major	Increased risk of hypervitaminosis A
Tetracycline antibiotics	Major	Increased risk of intracranial hypertension
Oral contraceptives	Moderate	Reduced efficacy of contraceptives
Alcohol	Moderate	Increased risk of liver damage

🚨 Major Interactions

Tetracyclines
Vitamin A supplements
Methotrexate
Oral contraceptives (reduced efficacy)

⚡ Moderate Interactions

Phenytoin
Corticosteroids
Antifungals (azole)

ℹ️ Minor Interactions

Alcohol
Antacids

🍽️ Food Interactions

High-fat meals increase absorption.

🍷 Alcohol Interaction

May increase risk of hepatotoxicity; avoid concurrent use.

🛡️ Safety & Warnings

Liver

Moderate

Kidney

Low

Heart

Low

Pregnancy

Category A

🚫 Contraindications

Pregnancy, breastfeeding, hypersensitivity to retinoids, hypervitaminosis A, severe hepatic impairment.

📊 Monitoring Parameters

Liver function tests, serum lipids, pregnancy test (monthly), CBC, renal function.

🤱 Lactation Safety

Contraindicated; excreted in breast milk.

💊 Overdose Management

Supportive care; symptoms include headache, vomiting, facial flushing, cheilitis, abdominal pain. No specific antidote.

⏰ Missed Dose

Take as soon as remembered unless near next dose; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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🔄 Substitutes for accufine 10mg softgel capsule

View All

Alternative brands with exact same active ingredient (Isotretinoin (10mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Happy Patient Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Regular Customer Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Verified User Jul 10, 2026