abamune tablet - Uses, Price, Side Effects & Substitutes
What is abamune tablet used for?
Abamune Tablet (Abacavir) is used to treat ANTI INFECTIVES. It contains Abacavir (300mg), which Abacavir is a nucleoside reverse transcriptase inhibitor (NRTI). It is converted. Always consult your doctor before use. Take as prescribed.
- Generic Name: Abacavir
- Manufacturer: Cipla Ltd
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ abamune tablet Uses & Benefits
Treatment of HIV-1 infection in combination with other antiretroviral agents.
Off-label uses: Post-exposure prophylaxis (PEP) in combination with other agents.
๐ Drug Information
| Generic Name(s) | Abacavir |
| Brand Name | Abamune Tablet |
| Manufacturer | Cipla Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Abacavir is a nucleoside reverse transcriptase inhibitor (NRTI). It is converted intracellularly to carbovir triphosphate, which competes with endogenous deoxyguanosine triphosphate and incorporates into viral DNA, causing chain termination.
Mechanism Steps
๐ก How to Take abamune tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of abamune tablet
โ Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Headache
- Fatigue
- Insomnia
๐จ Serious Side Effects
- Hypersensitivity reaction (fever, rash, malaise, GI symptoms)
- Lactic acidosis
- Hepatomegaly with steatosis
- Myocardial infarction
โ ๏ธ Rare Side Effects
- Pancreatitis
- Peripheral neuropathy
- Anaphylaxis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Methadone | Major | Increased methadone clearance; may require dose adjustment. |
| Ribavirin | Major | Increased risk of hepatotoxicity. |
| Ethanol | Moderate | Increased abacavir AUC by 41%. |
| Acetaminophen | Minor | Possible increased acetaminophen metabolism. |
๐จ Major Interactions
- Methadone
- Ribavirin
- Interferon alfa
- Orlistat
โก Moderate Interactions
- Ethanol
- Methotrexate
- Trimethoprim/sulfamethoxazole
โน๏ธ Minor Interactions
- Acetaminophen
- Phenobarbital
๐ฝ๏ธ Food Interactions
No significant food interactions; may be taken with or without food.
๐ท Alcohol Interaction
Alcohol may increase abacavir levels; avoid excessive alcohol consumption.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to abacavir; moderate to severe hepatic impairment; HLA-B*5701 positive patients.
๐ Monitoring Parameters
HIV viral load, CD4 count, hypersensitivity symptoms, hepatic function, HLA-B*5701 screening before initiation.
๐คฑ Lactation Safety
Not recommended; HIV-infected mothers should not breastfeed.
๐ Overdose Management
Limited experience; supportive care; hemodialysis may remove abacavir.
โฐ Missed Dose
If missed, take as soon as remembered unless almost time for next dose; do not double dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for abamune tablet
View AllAlternative brands with exact same active ingredient (Abacavir (300mg)):
-
a-bec tabletEmcure Pharmaceuticals Ltd โน1,557.22 7.1% COSTLIER
-
abhope 300mg tabletAbbott โน2,621.40 80.3% COSTLIER
-
virol 300mg tabletSun Pharmaceutical Industries Ltd โน7,215.00 396.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.