Acitretin 10mg Capsule (A Tret): Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Yellowing of skin or eyes (jaundice)
- Severe abdominal pain radiating to the back
- Severe headache with blurred vision or vomiting
- Sudden swelling of face, lips, or throat
- Difficulty breathing
- Blood in vomit or stool
- Decreased urine output
- Severe skin rash or blistering
- Persistent nausea and vomiting
- Chest pain or palpitations
If experiencing severe symptoms, call emergency services immediately.
What is a tret 10mg capsule used for?
This medicine is a prescription retinoid used to treat severe psoriasis and other skin disorders. It works by slowing down the rapid growth of skin cells and reducing inflammation. It must not be used during pregnancy due to severe birth defects.
- Generic Name: Acitretin (10mg)
- Manufacturer: Kaizen Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 a tret 10mg capsule के बारे में (Hindi Summary)
उपयोग: यह दवा एक्ट्रेटिन 10 मिलीग्राम कैप्सूल है, जिसका उपयोग गंभीर सोरायसिस (सोरायसिस), पस्टुलर सोरायसिस, एरिथ्रोडर्मिक सोरायसिस और कुछ अन्य त्वचा रोगों के इलाज के लिए किया जाता है। यह त्वचा की कोशिकाओं की तेजी से बढ़ने की प्रक्रिया को धीमा करती है और सूजन को कम करती है। यह दवा केवल डॉक्टर के पर्चे पर मिलती है और इसे डॉक्टर की देखरेख में ही लेना चाहिए। गर्भवती महिलाओं या गर्भवती होने की संभावना वाली महिलाओं को यह दवा बिल्कुल नहीं लेनी चाहिए क्योंकि इससे बच्चे में गंभीर जन्म दोष हो सकते हैं।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में होंठ सूखना, मुंह सूखना, नाक सूखना, आंखें सूखना और त्वचा सूखना शामिल हैं। कुछ लोगों को बाल पतले होना, खुजली, जोड़ों में दर्द और सिरदर्द भी हो सकता है। गंभीर दुष्प्रभावों में लिवर की समस्या, पैनक्रियाटाइटिस, आंखों की रोशनी में बदलाव और एलर्जी शामिल हैं। अगर आपको पीलिया, गंभीर पेट दर्द, या दृष्टि में कोई बदलाव दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को लेने से पहले और दौरान में गर्भावस्था परीक्षण कराना जरूरी है। महिलाओं को इलाज के दौरान और दवा बंद करने के 3 साल बाद तक गर्भधारण से बचने के लिए दो विश्वसनीय गर्भनिरोधक तरीकों का इस्तेमाल करना चाहिए। इलाज के दौरान और बंद करने के 2 महीने बाद तक शराब बिल्कुल न पिएं। विटामिन ए सप्लीमेंट न लें। धूप से बचें और सनस्क्रीन का इस्तेमाल करें। नियमित रूप से खून की जांच कराएं। दवा को डॉक्टर की सलाह के बिना बंद न करें।
💊 a tret 10mg capsule Uses & Benefits
[{"condition":"Severe plaque psoriasis","description":"This medicine helps reduce scaling, thickness, and redness of skin plaques in people with severe psoriasis who have not responded to other treatments.","evidence":"Well-established"},{"condition":"Pustular psoriasis","description":"It is used to treat pustular psoriasis, a severe form of psoriasis with pus-filled blisters on the skin.","evidence":"Well-established"},{"condition":"Erythrodermic psoriasis","description":"This medicine can help control widespread redness and scaling in erythrodermic psoriasis, a rare and serious form of psoriasis.","evidence":"Well-established"},{"condition":"Ichthyosis","description":"It is used to treat severe inherited ichthyosis, a group of disorders that cause dry, scaly skin.","evidence":"Well-established"},{"condition":"Darier disease","description":"This medicine may be prescribed for Darier disease, a genetic skin disorder that causes small, firm bumps on the skin.","evidence":"Moderate"},{"condition":"Lichen planus","description":"It is sometimes used for severe lichen planus, an inflammatory condition affecting the skin and mucous membranes.","evidence":"Limited"}]
Off-label uses: [{"condition":"Cutaneous lupus erythematosus","description":"This medicine has been used off-label for skin lesions of lupus, but evidence is limited.","evidence":"Limited"},{"condition":"Pityriasis rubra pilaris","description":"It may be used off-label for this rare skin disorder that causes reddish-orange scaling.","evidence":"Limited"},{"condition":"Graft-versus-host disease skin involvement","description":"Occasionally used off-label for skin symptoms of chronic graft-versus-host disease.","evidence":"Limited"}]
Primary treatment for: Severe psoriasis
Also treats: Pustular psoriasis, Erythrodermic psoriasis, Ichthyosis, Darier disease, Lichen planus
📋 Drug Information
| Generic Name(s) | Acitretin (10mg) |
| Brand Name | a tret 10mg capsule |
| Manufacturer | Kaizen Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | DERMA |
| Action Class | Retinoids- Second generation |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep the capsules in their original container, tightly closed. Do not refrigerate unless specified by the manufacturer. Keep out of reach of children and pets. |
| Shelf Life | The shelf life is typically 24 months from the date of manufacture, but check the expiry date on the package. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by binding to specific retinoic acid receptors in the skin cells. After binding, it alters the way genes are expressed in the skin, which normalizes the growth and maturation of skin cells. In psoriasis, skin cells grow too quickly and do not mature properly, leading to thick, scaly plaques. This medicine slows down this rapid growth and helps the skin cells mature normally. It also reduces inflammation in the skin by affecting immune cells and chemical messengers. The exact way it reduces inflammation is not fully understood, but it is known to affect the production of certain proteins that drive inflammation.
Mechanism Steps
💡 How to Take a tret 10mg capsule
Strength: Capsule, 10 mg
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 10 mg to 50 mg once daily, depending on the condition being treated and the patient's response. For psoriasis, treatment is often started at 10 mg to 25 mg once daily and increased gradually. The maximum recommended dose is 50 mg per day for most indications, but some patients may require up to 75 mg per day under close supervision. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and response to treatment. Regular monitoring is essential. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Dose selection should be cautious, and monitoring for liver, lipid, and bone effects should be more frequent. The dose must be individualized by a qualified clinician. |
| Renal Impairment | No specific dose adjustment is established for renal impairment. This medicine should be used with caution in patients with severe kidney disease. Consult a clinician for individualized dosing. |
| Hepatic Impairment | This medicine is contraindicated in severe liver disease. In mild to moderate liver impairment, dose reduction may be necessary, and liver function should be monitored closely. The dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is 50 mg for most indications, but up to 75 mg may be used in some cases under close supervision. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of a tret 10mg capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Methotrexate | Major | |
| Tetracyclines | Major | |
| Vitamin A | Major | |
| Alcohol | Major | |
| Phenytoin | Moderate | |
| Progestin-only contraceptives | Moderate | |
| Glyburide | Moderate | |
| Statins | Moderate | |
| Corticosteroids | Moderate | |
| Cyclosporine | Moderate |
🚨 Major Interactions
- Methotrexate
- Tetracyclines (e.g., doxycycline, minocycline)
- Vitamin A or other retinoids
- Alcohol
- Phenytoin
- Oral contraceptives (progestin-only)
⚡ Moderate Interactions
- Glyburide
- Statins
- Corticosteroids
- Cyclosporine
🍷 Alcohol Interaction
Alcohol must be completely avoided while taking this medicine and for at least two months after stopping. Alcohol can increase the risk of liver damage and can cause the medicine to be converted into another retinoid called etretinate, which stays in the body for a much longer time and increases the risk of birth defects. Even small amounts of alcohol can be harmful.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Pregnancy or women who may become pregnant during treatment or within 3 years after stopping","Breastfeeding","Severe liver disease","Severe kidney disease","Uncontrolled high cholesterol or triglycerides","Allergy to acitretin or other retinoids","Concurrent use of methotrexate or tetracyclines","Concurrent use of vitamin A or other retinoids"]
⚠️ Warnings & Precautions
["This medicine can cause severe birth defects. Women must use two forms of contraception and have regular pregnancy tests.","Do not donate blood during treatment or for 3 years after stopping.","Avoid alcohol completely during treatment and for 2 months after stopping.","Avoid vitamin A supplements.","Protect skin from sunlight and avoid tanning beds.","Regular blood tests are needed to monitor liver, lipids, and blood sugar.","Report vision changes, severe headaches, or abdominal pain immediately.","Use caution when driving or operating machinery if you have vision problems or dizziness.","Tell your doctor if you have diabetes, high cholesterol, liver disease, or kidney disease.","Do not share this medicine with others."]
🤱 Lactation Safety
This medicine passes into breast milk and can cause serious side effects in a nursing infant. Breastfeeding is not recommended while taking this medicine. Women should not breastfeed during treatment and for at least 3 years after stopping.
💊 Overdose Management
Overdose of this medicine may cause severe headache, nausea, vomiting, drowsiness, and increased intracranial pressure. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if the overdose was recent. Monitor vital signs and neurological status.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Before starting this medicine, you must have a negative pregnancy test and you must use two reliable forms of contraception for at least one month before treatment, during treatment, and for three years after stopping this medicine. Do not donate blood while taking this medicine or for three years after stopping it, because the medicine can be passed to a pregnant woman through transfusion. Avoid alcohol completely during treatment and for two months after stopping, as alcohol can increase the risk of liver problems and can convert this medicine back into another retinoid that stays in the body longer. Avoid vitamin A supplements and multivitamins containing vitamin A, as they can increase side effects. Protect your skin from sunlight and do not use sunlamps or tanning beds. Use a good sunscreen and wear protective clothing. Tell your doctor if you have diabetes, high cholesterol, liver disease, kidney disease, or if you drink alcohol regularly. Do not drive or operate heavy machinery if you have vision problems or feel dizzy. Regular blood tests for liver function, cholesterol, triglycerides, and blood sugar are essential. Do not share this medicine with anyone else. Keep all appointments with your doctor.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, especially dry skin, vision problems, and bone changes. Regular monitoring of liver, lipids, and bone health is important. Dose selection should be cautious.
🤰 Pregnancy Planning (TTC)
This medicine is absolutely contraindicated in pregnancy and in women planning to become pregnant. Women must use two reliable forms of contraception for at least one month before treatment, during treatment, and for three years after stopping. Regular pregnancy tests are required. If you become pregnant while taking this medicine, stop immediately and consult your doctor.
🏥 Post-Surgery Considerations
This medicine may affect wound healing and increase the risk of bleeding. Inform your surgeon that you are taking this medicine. It may need to be stopped before surgery. Consult your doctor for specific advice.
🦷 Dental Procedures
This medicine can cause dry mouth and increase the risk of dental problems. Inform your dentist that you are taking this medicine. Good oral hygiene is important. Dry mouth can be managed with saliva substitutes.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is generally safe while taking this medicine, but if you have joint or bone pain, avoid high-impact activities. Swimming may be soothing for dry skin, but avoid chlorinated pools if they irritate your skin. Always use sunscreen if exercising outdoors. Stay hydrated.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause vision problems, especially night blindness, which can affect driving and operating machinery. If you experience vision changes or dizziness, avoid these activities. Dry skin and lips can be managed with moisturizers. You may need to take time off for regular blood tests and doctor visits. Discuss any work-related concerns with your doctor.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Your doctor will decide when to stop based on your response and side effects. If you experience serious side effects, contact your doctor immediately. Stopping suddenly may cause a flare of your skin condition. Women must continue pregnancy prevention for 3 years after stopping.
📅 Long-Term Use Effects
Long-term use of this medicine can cause bone changes such as hyperostosis and increased risk of fractures. It can also cause persistent dry skin, hair thinning, and vision problems. Regular monitoring of liver function, lipids, and bone health is recommended. The medicine can stay in the body for a long time, so side effects may persist after stopping. Women must continue pregnancy prevention for 3 years after stopping.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can be used for mild to moderate psoriasis.
Evidence: Well-establishedLight therapy can help control psoriasis.
Evidence: Well-establishedAnother systemic treatment for severe psoriasis.
Evidence: Well-establishedTargeted immune therapies for severe psoriasis.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may affect the immune system, but it is not known to interact with vaccines. Live vaccines should be avoided if you are on other immunosuppressants. Consult your doctor before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label. Bring a copy of your prescription and a letter from your doctor explaining the medical need, especially for international travel. Store at room temperature and protect from extreme heat or cold. If crossing time zones, continue taking your dose at the same time each day as close as possible. Do not pack it in checked luggage; keep it in your carry-on. Check customs regulations for restricted medicines. Do not donate blood while traveling.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Improvement in skin lesions may begin within 2 to 4 weeks, but maximum benefit may take 2 to 3 months. It is important to continue treatment as prescribed.
A: No, alcohol must be completely avoided during treatment and for at least 2 months after stopping. Alcohol increases the risk of liver damage and prolongs the presence of the medicine in the body.
A: No, this medicine is absolutely contraindicated during pregnancy. It can cause severe birth defects. Women must use two forms of contraception and have regular pregnancy tests.
A: Common side effects include dry lips, dry skin, dry eyes, dry nose, peeling skin, itching, and hair thinning. These are usually manageable with moisturizers and lip balm.
A: Yes, regular blood tests are needed to monitor liver function, cholesterol, triglycerides, and blood sugar. Your doctor will schedule these tests.
A: No, you must not donate blood during treatment or for 3 years after stopping, because the medicine can be passed to a pregnant woman through transfusion.
🤔 Common Patient Concerns
🔄 Substitutes for a tret 10mg capsule
View AllAlternative brands with exact same active ingredient:
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acipsor 10mg capsuleKivi Labs Ltd ₹272.81 7.8% COSTLIER
-
acetroin 10mg tabletNidus Pharma Pvt Ltd ₹304.69 20.4% COSTLIER
-
zoratame 10mg capsuleCipla Ltd ₹328.13 29.6% COSTLIER
-
sorid 10mg capsuleOchoa Laboratories Ltd ₹336.07 32.8% COSTLIER
-
acitrin 10mg capsuleIpca Laboratories Ltd ₹336.15 32.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Acitretin is a cure for psoriasis.
Fact: Acitretin is not a cure. It helps control symptoms but does not eliminate the disease. - Myth: You can stop acitretin as soon as your skin clears.
Fact: Stopping suddenly can cause a flare. Always consult your doctor before stopping. - Myth: Acitretin is safe to take during pregnancy.
Fact: Acitretin causes severe birth defects and is absolutely contraindicated in pregnancy. - Myth: You can drink alcohol in moderation while on acitretin.
Fact: Alcohol must be completely avoided as it increases liver toxicity and prolongs the drug's presence in the body.
🔄 Alternative Options
Generic Alternatives
- Acitretin 10 mg capsule
Brand Alternatives
- A Tret 10mg Capsule