Sodium Chloride 0.65% w/v is a sterile, isotonic, buffered, or non-buffered aqueous solution for nasal irrigation and ocular use. It is classified as an electrolyte replenisher and nasal decongestant. In the Indian context, it is widely used as a non-pharmacological, physiological saline solution for managing symptoms of allergic rhinitis, sinusitis, and dry eye syndrome. Its 0.65% concentration is slightly hypotonic compared to plasma but is well-tolerated for mucosal irrigation.
Adult: Nasal Spray/Drops: 2-3 sprays or drops into each nostril, 3-6 times daily or as needed. Nasal Irrigation (via bulb syringe/neti pot): 100-250 ml per nostril, 1-2 times daily.
Note: For Nasal Spray: Blow nose gently. Shake bottle. Tilt head slightly forward. Insert tip into nostril, spray away from nasal septum. Breathe gently inward. Repeat for other nostril. For Nasal Irrigation: Use sterile, lukewarm solution. Use proper device (neti pot, bulb). Lean over sink, head tilted. Pour solution into one nostril, allowing it to drain from the other. Blow nose gently afterward. For Eyes: Tilt head back, pull lower eyelid down, instill 1-2 drops. Close eye gently for 30 seconds.
As a slightly hypotonic saline solution, it works by moistening the nasal and ocular mucosal surfaces. It helps to liquefy viscous mucus, facilitating its clearance (mucociliary clearance). It washes away allergens, irritants, and crusts, providing a soothing effect. It helps restore the physiological ionic environment on the mucosal surface.
Pregnancy: Category A (US FDA). Sodium Chloride is considered safe in pregnancy for topical use as it is a normal body constituent. No known risk.
Driving: No effect. May cause temporary blurred vision if used in eyes.
| No significant pharmacokinetic drug interactions. | Mechanical washing may reduce contact time of other intranasal medications. | Moderate |
Same composition (Sodium Chloride (0.65% w/v)), different brands: