A topical nasal decongestant and soothing solution combining two sympathomimetic amines (Naphazoline and Phenylephrine) for rapid vasoconstriction with two counterirritants (Camphor and Menthol) for a cooling sensation and symptomatic relief of nasal congestion. Primarily used for temporary relief from nasal and sinus congestion associated with allergic rhinitis, common cold, and sinusitis. It is intended for short-term use only.
Adult: 2-3 drops or 1-2 sprays into each nostril. Not to be used more than every 4-6 hours. Maximum: 3-4 times in 24 hours.
Note: 1. Blow nose gently to clear nostrils. 2. Tilt head back slightly. 3. Insert dropper/tip into nostril without touching the nasal lining. 4. Squeeze bottle for drops or pump for spray while breathing in gently. 5. Repeat for other nostril. 6. Avoid sniffing forcefully. 7. Clean the dropper/tip after each use. Do not share the bottle.
Naphazoline and Phenylephrine are direct-acting sympathomimetic amines that stimulate alpha-1 adrenergic receptors on the vascular smooth muscle within the nasal mucosa. This causes vasoconstriction, leading to reduced blood flow, decreased edema, and shrinkage of swollen nasal tissues, thereby relieving nasal obstruction. Camphor and Menthol act as topical counterirritants and mild local anesthetics. They stimulate cold-sensitive TRPM8 receptors in the nasal mucosa and skin, producing a cooling sensation that subjectively improves airflow and provides relief from irritation.
Pregnancy: Category C (US FDA). No adequate and well-controlled studies in pregnant women. Should be used only if the potential benefit justifies the potential risk to the fetus. Systemic absorption of sympathomimetics can reduce uterine blood flow. Avoid especially in first trimester.
Driving: May cause dizziness or blurred vision. Patients should not drive or operate machinery if they experience these effects.
| Monoamine Oxidase Inhibitors (MAOIs) - Phenelzine, Tranylcypromine | Risk of severe, potentially fatal hypertensive crisis due to potentiation of sympathomimetic effects. | Contraindicated |
| Other Sympathomimetics (Oral/Parenteral) - Pseudoephedrine, Ephedrine | Additive adrenergic effects, increasing risk of hypertension, tachycardia, and arrhythmias. | Major |
| Beta-blockers (non-selective) - Propranolol | Unopposed alpha-adrenergic stimulation can lead to severe hypertension and bradycardia. | Major |
| Tricyclic Antidepressants (TCAs) - Amitriptyline, Imipramine | May potentiate pressor effects of phenylephrine and naphazoline. | Moderate |
| Ergot Alkaloids - Ergotamine | Increased risk of severe vasoconstriction and ischemia. | Major |
| Antihypertensives | May decrease the efficacy of antihypertensive therapy. | Moderate |
Same composition (Camphor (0.01% w/v) + Menthol (0.005% w/v) + Naphazoline (0.05% w/v) + Phenylephrine (0.12% w/v)), different brands: