A high-potency, multi-strain probiotic formulation containing a defined quantity of live, freeze-dried lactic acid bacteria (primarily Lactobacillus species) and Bifidobacteria. It is designed to restore and maintain a healthy gut microbiota, which is crucial for digestive health, immune modulation, and metabolic functions. The freeze-drying process ensures long-term stability and viability of the bacteria until consumption.
Adult: 112.5 Billion CFU (1 sachet/capsule) once or twice daily, as directed. For AAD prevention: Start with antibiotics and continue for 1-2 weeks after antibiotic course. For IBS: Once daily for at least 4 weeks to assess effect.
Note: Take with or immediately after a meal (preferably breakfast or lunch) to buffer gastric acid. For sachets: Mix the powder in a small amount of cool or lukewarm water (<40°C), milk, or yogurt. Do not mix with hot liquids. Drink immediately. For capsules/tablets: Swallow whole with a glass of water. Do not crush or chew enteric-coated capsules. Maintain adequate hydration.
Exerts beneficial effects through multiple mechanisms: 1) Competitive Exclusion: Adheres to intestinal epithelium, competing with pathogens for binding sites and nutrients. 2) Production of Antimicrobial Substances: Lactic acid bacteria produce bacteriocins, organic acids (lactic acid, acetic acid), and hydrogen peroxide, creating an unfavorable environment for pathogenic bacteria. 3) Immunomodulation: Enhances innate and adaptive immunity by modulating cytokine profiles, increasing secretory IgA production, and interacting with gut-associated lymphoid tissue (GALT). 4) Strengthening Gut Barrier: Promotes mucin production and tight junction protein expression, reducing intestinal permeability ('leaky gut'). 5) Metabolic Functions: Ferment indigestible fibers to produce SCFAs, which serve as an energy source for colonocytes and have systemic anti-inflammatory effects.
Pregnancy: Category A (as per microbial supplements). Considered safe. Probiotics are commonly used during pregnancy and may help reduce risk of gestational diabetes, pre-eclampsia, and infant eczema. However, use should be under medical advice.
Driving: No effect on driving ability.
| Antibiotics (e.g., Ciprofloxacin, Amoxicillin) | Antibiotics may kill the probiotic bacteria, reducing efficacy. Conversely, probiotics may help prevent antibiotic-associated side effects. | Moderate |
| Immunosuppressants (e.g., Cyclosporine, Tacrolimus, high-dose corticosteroids) | Increased risk of probiotic-associated systemic infection in immunocompromised hosts. | Major |
| Antifungals (e.g., Fluconazole) | Unlikely to affect bacteria, but simultaneous use is common in clinical practice without noted interaction. | Minor |
| Sulfasalazine | Probiotics may enhance the metabolism of sulfasalazine to 5-ASA, potentially altering its local effect. Clinical significance unclear. | Moderate |
Same composition (Live Freeze Dried Lactic Acid Bacteria and Bifidobacteria (112.5Billion CFU)), different brands: